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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Future Target Molecules for Influenza Treatment
- Source: Mini Reviews in Medicinal Chemistry, Volume 8, Issue 5, May 2008, p. 491 - 495
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- 01 May 2008
Abstract
Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.
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