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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment
- Source: Mini Reviews in Medicinal Chemistry, Volume 8, Issue 5, May 2008, p. 496 - 518
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- 01 May 2008
Abstract
We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
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