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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Tubulin as an Antiprotozoal Drug Target
- Source: Mini Reviews in Medicinal Chemistry, Volume 2, Issue 6, Dec 2002, p. 519 - 529
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- 01 Dec 2002
Abstract
Since tubulin is a known anticancer and anthelmintic drug target, the investigation of protozoal tubulin could lead to the development of new antiparasitic drugs. This review outlines the current state of knowledge concerning drug-mammalian tubulin interactions, the effects of antimicrotubule agents on parasites and parasite tubulin, and our current hypotheses regarding the development of selective ligands for protozoal tubulin as antiparasitic drug candidates.
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