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2000
Volume 2, Issue 6
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

αVβ3 integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.

© Bentham Science Publishers
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/content/journals/mrmc/10.2174/1389557023405602
2002-12-01
2025-10-28

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  • Article Type:     Review Article
Keyword(s): activity and selectivity; antagonists; cell surface protein; heterodimeric non-covalent proteins; pseudo-peptides; pseudo-peptidic antagonists; snake venom proteins; thrombotic disorder treatment; tumour metastasis; vitronectin receptor

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