f Nuclei-targeted Therapeutic Delivery: A Novel Concept for the Treatment of Cancer

References

1. SaklaniS. Recent Patterns of Cancer Incidence and Mortality.In: Global and Indian Scenario Nanoparticles in Cancer Theranostics.Boca Raton, FLCRC Press20244052
   [Google Scholar]
2. FuX. ShiY. QiT. QiuS. HuangY. ZhaoX. SunQ. LinG. Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting.Signal Transduct. Target. Ther.20205126210.1038/s41392‑020‑00342‑0 33154350
   [Google Scholar]
3. RoyS.M. GargV. SivaramanS.P. BarmanS. GhoshC. BagP. MohanasundaramP. MajiP.S. BasuA. DirisalaA. GhoshS.K. MaityA.R. Overcoming the barriers of nuclear-targeted drug delivery using nanomedicine-based strategies for enhanced anticancer therapy.J. Drug Deliv. Sci. Technol.20238310440810.1016/j.jddst.2023.104408
   [Google Scholar]
4. HuynhM. VinckR. GibertB. GasserG. Strategies for the nuclear delivery of metal complexes to cancer cells.Adv. Mater.20243616231143710.1002/adma.202311437 38174785
   [Google Scholar]
5. SakiyamaY. MazurA. KapinosL.E. LimR.Y.H. Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy.Nat. Nanotechnol.201611871972310.1038/nnano.2016.62 27136131
   [Google Scholar]
6. GoyalP. MalviyaR. Advances in nuclei targeted delivery of nanoparticles for the management of cancer.Biochim. Biophys. Acta Rev. Cancer20231878318888110.1016/j.bbcan.2023.188881 36965678
   [Google Scholar]
7. XiaW. TaoZ. ZhuB. ZhangW. LiuC. ChenS. SongM. Targeted delivery of drugs and genes using polymer nanocarriers for cancer therapy.Int. J. Mol. Sci.20212217911810.3390/ijms22179118 34502028
   [Google Scholar]
8. ZhangJ. HuangL. GeG. HuK. Emerging epigenetic‐based nanotechnology for cancer therapy: Modulating the tumor microenvironment.Adv. Sci.2023107220616910.1002/advs.202206169 36599655
   [Google Scholar]
9. NieY. FuG. LengY. Nuclear delivery of nanoparticle-based drug delivery systems by nuclear localization signals.Cells20231212163710.3390/cells12121637 37371107
   [Google Scholar]
10. LiN. YangH. YuZ. LiY. PanW. WangH. TangB. Nuclear-targeted siRNA delivery for long-term gene silencing.Chem. Sci.2017842816282210.1039/C6SC04293G 28553519
    [Google Scholar]
11. LuJ. WuT. ZhangB. LiuS. SongW. QiaoJ. RuanH. Types of nuclear localization signals and mechanisms of protein import into the nucleus.Cell Commun. Signal.20211916010.1186/s12964‑021‑00741‑y 34022911
    [Google Scholar]
12. XuD. FarmerA. ChookY.M. Recognition of nuclear targeting signals by Karyopherin-β proteins.Curr. Opin. Struct. Biol.201020678279010.1016/j.sbi.2010.09.008 20951026
    [Google Scholar]
13. ZhaoJ. ZhaoF. WangX. FanX. WuG. Secondary nuclear targeting of mesoporous silica nano-particles for cancer-specific drug delivery based on charge inversion.Oncotarget2016743701007011210.18632/oncotarget.12149 27661121
    [Google Scholar]
14. JainS. HirstD.G. O’SullivanJ.M. Gold nanoparticles as novel agents for cancer therapy.Br. J. Radiol.201285101010111310.1259/bjr/59448833 22010024
    [Google Scholar]
15. WatermannA. BriegerJ. Mesoporous silica nanoparticles as drug delivery vehicles in cancer.Nanomaterials20177718910.3390/nano7070189 28737672
    [Google Scholar]
16. ZhaoY. YueP. PengY. SunY. ChenX. ZhaoZ. HanB. Recent advances in drug delivery systems for targeting brain tumors.Drug Deliv.202330111810.1080/10717544.2022.2154409 36597214
    [Google Scholar]
17. YaoJ. FanY. LiY. HuangL. Strategies on the nuclear-targeted delivery of genes.J. Drug Target.2013211092693910.3109/1061186X.2013.830310 23964565
    [Google Scholar]
18. SarikhaniE. PatelV. LiZ. MeganathanD.P. RahmaniK. SadrL. HosseiniR. VisdaD. ShuklaS. Naghsh-NilchiH. BalajiA. McMahonG. ChenS. SchönebergJ. McHughC.A. ShiL. JahedZ. Engineered nanotopographies induce transient openings in the nuclear membrane.Adv. Funct. Mater.2025356241003510.1002/adfm.202410035
    [Google Scholar]