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2000
Volume 25, Issue 17
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Introduction
Objective

Antimicrobial resistance (AMR) has become a global controversial issue, making conventional treatments less effective. Hence, the design and development of new and efficient antimicrobial agents are on the researchers’ agenda to reduce death rates and health care costs. In this regard, chlorine-containing compounds have been the center of attention. This review highlights the antimicrobial potential of chlorine-containing natural and semi-synthetic compounds, aiming to identify versatile candidates effective against microorganisms.

Methods

The literature was comprehensively surveyed using Google Scholar, Web of Science, Scopus, and PubMed, focusing on studies published since 2016, focusing on the antimicrobial properties of natural and semi-synthetic chlorinated compounds.

Results

Natural chlorinated compounds have shown remarkable antimicrobial activity, generally more potent than their semi-synthetic counterparts.

Discussion

The strong activity against resistant strains like MRSA underlines their therapeutic potential in addressing pressing clinical challenges. Nature-derived scaffolds serve as a promising foundation for the development of novel antimicrobial agents.

Conclusion

Several naturally occurring compounds have proven more effective than their semi-synthetic derivatives, making them attractive candidates for addressing the growing threat of AMR.

© 2025 Bentham Science Publishers
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/content/journals/mrmc/10.2174/0113895575396696250904113228
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Antimicrobial Activity of Naturally Occurring and Semi-Synthetic Chlorinated Compounds
Mini Rev Med Chem 25, 1299 (2025); https://doi.org/10.2174/0113895575396696250904113228
/content/journals/mrmc/10.2174/0113895575396696250904113228
/content/journals/mrmc/10.2174/0113895575396696250904113228
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  • Article Type:     Review Article
Keyword(s): Antibiotic development; antimicrobial activity; chlorine-containing compounds; minimum inhibitory concentration; natural compounds; resistance; semi-synthetic

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