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Abstract

Cancer is a major global health disease characterized by uncontrolled cell proliferation and invasiveness. The complexity of its etiology, involving genetic mutations and environmental influences as well as unhealthy lifestyles, necessitates innovative therapeutic approaches. However, peptide-based therapies will offer significant potential, their high specificity and efficacy notwithstanding, in targeting cancerous cells. Poor stability, rapid degradation, and limited bioavailability pose significant challenges to their clinical utility. Nano-particle-based delivery systems are considered a revolutionary approach for delivering therapeutic peptides with better stability, targeted delivery, and controlled release. In this comprehensive review, the recent advances in nano-carrier-based peptide delivery systems for cancer therapeutics have been discussed. Different types of nano-carriers, like lipid-based systems, namely liposomes, polymeric micelles, inorganic nanoparticles, and hybrid systems, have been discussed with their mechanisms of cellular targeting, advantages, limitations, and clinical applications. Notable formulations such as Doxil and Abraxane demonstrate the significance of nanoparticle-based therapeutic interventions in clinical settings. A significant section focuses on combination therapies, multifunctional nanoparticles, and the integration of emergent technologies to surpass biological barriers. However, many challenges remain, including toxicity, scalability, and regulatory issues. In order to maximize nanocarrier design and enhance therapeutic results, this review focusses more on personalized medicine and ongoing innovation. To sum up, nano carriers do hold revolutionary promise for cancer peptide therapy, offering enhanced efficacy, decreased side effects, and precise targeting. To turn these discoveries into broad clinical uses and usher in a new era of cancer treatment, more research is necessary.

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2025-04-16
2025-08-16

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A Comprehensive Review on Advancements in Nanocarriers-Based Peptide Delivery for Cancer Therapeutics
Bentham Science Publishers ; https://doi.org/10.2174/0118764029358553250325040749
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  • Article Type:     Review Article
Keywords: cancer therapeutics ; Nanoparticles ; targeted drug delivery ; lipid-based nano carriers ; peptide delivery ; personalized medicine

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