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image of Therapeutic Potential of Lobelia inflata in Promoting Wound Healing in Male Wistar Rat

Abstract

Aim

To evaluate the wound-healing properties of extract through assessments using incision and excision wound models in Wistar rats.

Objective

To determine the effectiveness of ointment at different concentrations (5% and 10%) in promoting wound contraction, tensile strength, and tissue remodeling, and to compare its efficacy with a standard wound-healing agent (1% Betadine).

Background

Wound healing is a critical biological process involving a series of intricate steps, including hemostasis, inflammation, proliferation, and remodeling, to restore tissue integrity. Interest in natural wound-healing agents has surged due to their potential therapeutic benefits and fewer side effects. This study investigates the efficacy of , a plant known for its medicinal properties, in enhancing wound healing.

Materials & Methods

Thirty adult male Wistar rats with age group more than 9 weeks were randomly divided into five groups (n=6 per group): Group I served as the normal control (untreated), Group II received a simple ointment base (vehicle control), Group III was treated with 1% Betadine ointment (standard group), Group IV was treated with 5% ointment, and Group V with 10% ointment. Two wound models were employed: in the incision model, a linear full-thickness dorsal skin incision was created, and wound contraction and tensile strength were assessed over time. In the excision model, full-thickness circular wounds were developed on the back, with wound closure rate and epithelialization evaluated. Additionally, histological analysis of healed tissues was conducted to assess collagen deposition, angiogenesis, and re-epithelialization.

Results

Treatment with ointment (5% and 10%) significantly improved wound healing, with the 10% ointment (Group V) showing the fastest wound closure and healing. Increased tensile strength was observed in the treated groups, with Group V outperforming Group IV. Histopathological analysis revealed enhanced collagen deposition, angiogenesis, and re-epithelialization, particularly in the 10% group, highlighting its superior wound-healing efficacy.

Conclusion: Lobelia inflata

extract, particularly at a 10% concentration, demonstrates significant potential as a wound-healing agent. It promotes faster wound contraction, improved tensile strength, and enhanced tissue remodeling, making it a promising natural alternative for wound care.

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2025-04-28
2025-09-26

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Therapeutic Potential of Lobelia inflata in Promoting Wound Healing in Male Wistar Rat
Bentham Science Publishers ; https://doi.org/10.2174/0118764029356142250413012628
/content/journals/mns/10.2174/0118764029356142250413012628
/content/journals/mns/10.2174/0118764029356142250413012628
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  • Article Type:     Research Article
Keywords: Lobelia inflata ; wound healing ; incision & excision models ; tissue remodeling ; inflammation ; Herbal extract

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