Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents) - Volume 16, Issue 3, 2016

Stromal vascular fraction of the adipose tissue is recognized as reservoir of the cell populations with stem and progenitor properties. Besides the roles of adipose tissue stem and progenitor cells (ASPCs) in adipose tissue development and homeostasis, particularly interest is given to their functions in adipose tissue expansion and obesity. Obesity-driven low-grade chronic inflammation, reduction of oxygen level in adipose ti Read More

Background: Angiotensin and its precursor’s peptides contribute to multiple biological functions and regulate several important mechanisms like hormone production, fluid balance, growth, and apoptosis throughout the body. The function of Ang-II is generally mediated through AT1R and AT2R which monitor various crucial pathways. Angiotensin receptors are largely expressed in various organs such as kidney, heart, adre Read More

Background: Vasoactive intestinal peptide (VIP) is a 3.3 kDa pleiotropic protein with a broad expression profile that displays immune modulating activities. VIP binds two G protein-coupled receptors called Vasoactive Intestinal Pepide/Pituitary Adenylate Cyclase activating polypeptide receptor (VPAC) 1 and 2 that elicit multiple downstream signaling molecules, including adenylate cyclase. VIP differentially regulates over 300 gen Read More

Background: The immortalized human epidermal keratinocytes HaCaT often serve as an experimental model of psoriasis. Previously, we reported that Th1 cytokines TNF, IFN-γ and IL17 suppressed proliferation in cultured HaCaT cells. Our results also suggested that at certain conditions, HaCaT cells could become susceptible to the named cytokines. Objective: The aim of this study was to analyze the consequences of FOS Read More