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2000
Volume 25, Issue 7
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873
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Abstract

Objectives

In the last two decades, scientists have gained a better understanding of several aspects of pituitary development. The signaling pathways that govern pituitary morphology and development have been identified, and the compensatory relationships among them are now known.

Aims

This paper aims to emphasize the wide variety of relationships between Pituitary Gland and Stem cells in hormone Production and disease prevention.

Methods

Based on many case reports and several types of research, a wide variety of relationships between the Pituitary Gland and Stem cells in the aspect of hormone Production and disease prevention are reviewed in this literature. In this paper, we focus on various roles and functions of the pituitary gland, the responsibilities of stem cells as a mode of hormone production, and disease prevention.

Conclusion

Within this period, more was discovered concerning the contributions made to the transcription factors within the pituitary development, with factors such as Prop1, Pitx1, and Sox2 being defined as important in the development and action of hormone-secreting cells. They are also required in the appropriate specification of the cell types in the pituitary gland and the persistence of the progenitors. Manipulation of these factors causes developmental defects as well as tumors, thus the necessity of knowing the precise function and interaction of these factors. A closer look at these transcription factors could help expand treatment options for structural defect development or give rise to pituitary adenomas.

It has been established that signaling pathways such as Sonic Hedgehog (Shh), Wnt, and Notch play a part in modulating pituitary development. These pathways are involved in regulating important processes such as cellular proliferation, differentiation, and organization of the pituitary gland tissues. Breaching any of these pathways has been correlated with the development of various pituitary-related conditions including adenomas and congenital hypopituitarism. Moving forward, further studies of these pathways and their associations with stem cells could provide a better understanding of disease processes and approaches to manage them. This way, there is a possibility of developing new approaches aimed at treating the cause of the dysfunction of the pituitary gland by modulating its specific signaling activities.

Promising directions for the stimulation of hormone synthesis and restoration of normal pituitary function upon its disorders tissue regrowth could be found in stem cell application. The fact that one can generate functional pituitary cells from iPSCs for instance provides new avenues both for the understanding of pituitary disease mechanisms as well as for personalized medicine. It is possible to utilize these stem cell-derived cells for modeling disease, drug discovery or even transplantation to restore the function of the damaged pituitary gland. In the future, however, the focus ought to be on the effective application of stem cell therapies that have been research during the development of better differentiation processes.

The recent understanding of the system that carries the hypothalamic hormones to the pituitary gland, the hypophyseal portal vasculature, has had its implications too. This factorial consideration emphasizes the role of the vascular component in the control of pituitary activity – the release of hormones by the pituitary gland. Exploring stem cell-hypophyseal portal system interactions may open new avenues of treatment for diseases associated with deficient hormone transportation and/or pituitary dysfunction.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/emiddt/10.2174/0118715303314551241031093717
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Relationship between Pituitary Gland and Stem Cell in the Aspect of Hormone Production and Disease Prevention: A Narrative Review
Endocr Metab Immune Disord Drug Targets 25, 509 (2025); https://doi.org/10.2174/0118715303314551241031093717
/content/journals/emiddt/10.2174/0118715303314551241031093717
/content/journals/emiddt/10.2174/0118715303314551241031093717
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  • Article Type:     Review Article
Keyword(s): adenohypophysis; Anterior pituitary; neural ectoderm; organizing center; rathke’s pouch; stem cell

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