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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications
- Source: Drug Metabolism Letters, Volume 1, Issue 2, Apr 2007, p. 137 - 142
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- 01 Apr 2007
Abstract
Different functional alleles for each subtype of cytochrome P450 (CYPs), thiopurine S-methyltransferase (TPMT), glutathione S-transferase (GST) and sulfotransferase (SULT) enzymes, have been identified. In this review, the genetic polymorphisms of drug-metabolizing enzymes in the Japanese population and their effects on metabolic activity are described in detail.
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