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image of Moringa oleifera-Loaded Hydrogel: Assessment of Wound Healing Potential in an Animal Model

Abstract

Introduction

Phytopharmaceutical has gained attention for its potential in wound healing, including antimicrobial and antioxidant attributes by various mechanisms. Extracts from this plant have shown promise in accelerating wound healing processes, enhancing fibroblast cell proliferation and migration, and providing antioxidant benefits. The primary objective of this research was to evaluate the therapeutic efficacy of extract-loaded hydrogels for wound healing applications.

Methods

extract-loaded hydrogels were prepared by incorporating extract into varying concentrations of carbopol-940 and were subjected to characterizations. The optimized hydrogel (MH1) was further subjected to evaluations in an excision wound animal model.

Result

Results of evaluation of herbal hydrogels showed optimum pH, viscosity, spreadability, and swelling index. drug release profiles showed up to 87.01 ± 0.74% release over a period of 24 h. Further, the studies revealed the accelerated wound healing potential of the hydrogel, which was comparable to the marketed formulation.

Discussion

The improved therapeutic activity of the hydrogel exhibited significant and comparable wound healing activity owing to the presence of antioxidants and antimicrobials in the extract. Also, the hydrogel facilitated wound healing through maintaining a moist environment at the wound bed as well as preventing microbial growth credited to antimicrobial attribute.

Conclusion

This study strongly highlights the efficacy of the -loaded hydrogel as a powerful and innovative wound dressing, presenting it as a compelling candidate for next-generation wound care and advanced therapeutic wound management.

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2025-09-02
2025-10-30

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Moringa oleifera-Loaded Hydrogel: Assessment of Wound Healing Potential in an Animal Model
Bentham Science Publishers ; https://doi.org/10.2174/0122103031392306250828013131
/content/journals/ddl/10.2174/0122103031392306250828013131
/content/journals/ddl/10.2174/0122103031392306250828013131
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  • Article Type:     Research Article
Keywords: wound healing ; Cabopol-940 ; gallic acid ; Moringa oleifera ; rutin ; hydrogels

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