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2000
Volume 22, Issue 2
  • ISSN: 1573-4048
  • E-ISSN: 1875-6581

Abstract

Introduction

Preeclampsia is a significant cause of maternal and fetal morbidity, highlighting the importance of early detection. While serum cystatin C is a promising biomarker for detecting renal impairment, its role in Vietnamese preeclamptic women remains underexplored.

Objectives

This study aimed to evaluate the applicability of serum cystatin C and other renal biomarkers in assessing preeclampsia and investigate factors influencing serum cystatin C levels, with a focus on improving early detection and management in the Mekong Delta region of Vietnam.

Materials and Methods

A cross-sectional study was conducted on 50 pregnant women diagnosed with preeclampsia and 50 healthy, normotensive, non-proteinuric pregnant women. Data collected included age, height, weight, body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP), gestational age, platelet count, and various biochemical parameters, such as serum uric acid, urea, creatinine, cystatin C, urine creatinine, urine volume, 24-hour creatinine clearance (CrCl), 24-hour urine protein, serum glutamic-oxaloacetic transaminase (SGOT), and serum glutamic-pyruvic transaminase (SGPT). These parameters were analyzed using the t-test, Mann-Whitney U test, and correlation and regression analyses. The area under the curve (AUC) was used to describe the relationship between sensitivity and specificity at different cut-off points.

Results and Discussion

Serum cystatin C and 24-hour urine protein levels were higher in the severe preeclampsia group, while the median 24-hour urine volume was lower compared to the healthy group. Weak negative correlations were observed between serum cystatin C levels and DBP in the healthy group and 24-hour CrCl in the non-severe preeclampsia group (<0.05). Moderate positive correlations were found between serum cystatin C levels and serum creatinine in the non-severe preeclampsia group and between pregnant women’s age and serum creatinine in the severe preeclampsia group (<0.05). Notably, serum cystatin C levels strongly correlated with gestational age in the severe preeclampsia group (<0.05). SGOT, SGPT, 24-hour urine protein, SBP, and maternal weight were identified as significant independent predictors of serum cystatin C levels.

Conclusion

While serum cystatin C levels demonstrated strong predictive value for preeclampsia (AUC=0.980, <0.001), they showed limited utility in distinguishing between severe and non-severe forms of the condition. Future studies should explore additional biomarkers to complement its predictive value. Nonetheless, its correlation with key renal function markers highlights its potential role in preeclampsia management.

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2025-06-02
2026-03-05

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Serum Cystatin C and its Correlation with Renal Function and Clinical Parameters in Vietnamese Preeclamptic Women
Curr Womens Health Rev. 22, e15734048372639 (2026); https://doi.org/10.2174/0115734048372639250526052133
/content/journals/cwhr/10.2174/0115734048372639250526052133
/content/journals/cwhr/10.2174/0115734048372639250526052133
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  • Article Type:     Research Article
Keyword(s): Cystatin C; gestation; kidney damage; perinatal morbidity; preeclampsia; pregnancy

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