Skip to content
2000
Volume 23, Issue 4
  • ISSN: 1570-1611
  • E-ISSN: 1875-6212

Abstract

Background

Among the organ damage mediated by hypertension, cardiac lesions hold significant importance. Numerous authors focus on hypertensive heart disease (HHD) rather than exclusively on left ventricular hypertrophy (LVH).

Objectives

This narrative review aims to assess the incorporation of the concept of 'hypertensive heart disease' (HHD) in hypertension (HTN) guidelines. Furthermore, if HHD is not addressed, the review will evaluate the potential benefits of including this concept in future studies.

Methods

The following databases were searched: Scopus, Medline, Springer, Science Direct, Wiley, SAGE, Cambridge, Oxford Journals, and Google Scholar. Attention was given to the guidelines related to hypertension (HTN); the search items were “guidelines” and “hypertension.” Within these guidelines, we specifically sought references to ‘hypertensive heart disease’.

Results

The concept of “HHD” is clearly advantageous compared to “HTN LVH,” as it not only addresses LVH but also considers other structures of the heart that may be severely affected, which can significantly influence treatment. The concept of “hypertensive heart disease” is mentioned in only 8 out of 36 guidelines on HTN. The therapeutic implications and recommendations are absent in the guidelines.

Conclusion

The concept of HHD is reasonable and evidence-based, and there is no reason to focus only on LVH when considering HTN-induced damage to the heart. It is time to update our recommendations for heart treatment by using the phrase “Treatment of hypertensive heart disease” instead of “Treatment of hypertensive LVH.” This update can enhance our awareness of the need to improve not only HTN LVH but the other parts of the heart as well.

Loading

Article metrics loading...

/content/journals/cvp/10.2174/0115701611351415241212092014
2025-01-21
2025-10-15
Loading full text...

Full text loading...

References

  1. WhiteP.D. The heart in hypertension and in nephritis.Boston Med. Surg. J.1923189251015101810.1056/NEJM192312201892502
    [Google Scholar]
  2. VasanR.S. SongR.J. XanthakisV. Hypertension-mediated organ damage: Prevalence, correlates, and prognosis in the community.Hypertension202279350551510.1161/HYPERTENSIONAHA.121.18502 35138872
    [Google Scholar]
  3. OhJ.S. LeeC.H. ParkJ. ParkH.K. HwangJ.K. Hypertension-mediated organ damage and long-term cardiovascular outcomes in asian hypertensive patients without prior cardiovascular disease.J. Korean Med. Sci.20203548e40010.3346/jkms.2020.35.e400 33316856
    [Google Scholar]
  4. ĐorđevićD.B. KoračevićG.P. ĐorđevićA.D. LovićD.B. Hypertension and left ventricular hypertrophy.J. Hypertens.20244291505151510.1097/HJH.0000000000003774 38747417
    [Google Scholar]
  5. ZdravkovicM. KlasnjaS. PopovicM. Cardiac magnetic resonance in hypertensive heart disease: time for a new chapter.Diagnostics202213113710.3390/diagnostics13010137 36611429
    [Google Scholar]
  6. KoraćevićG. MićićS. StojanovićM. Beta-blockers in hypertensive left ventricular hypertrophy and atrial fibrillation prevention.Curr. Vasc. Pharmacol.2024221192710.2174/0115701611264647231110101700 38031765
    [Google Scholar]
  7. CuspidiC. GiovanniniR. TadicM. Left atrial stiffness: a novel marker of hypertension-mediated organ damage on the horizon?Hypertens. Res.202144336536710.1038/s41440‑020‑00582‑1 33257816
    [Google Scholar]
  8. TacklingG. BorhadeM.B. Hypertensive Heart Disease.StatPearls. Treasure IslandFL: StatPearls Publishing2024Available from: https://www.ncbi.nlm.nih.gov/books/NBK539800/
    [Google Scholar]
  9. KreutzR. BrunströmM. BurnierM. 2024 european society of hypertension clinical practice guidelines for the management of arterial hypertension.Eur. J. Intern. Med.202412611510.1016/j.ejim.2024.05.033 38914505
    [Google Scholar]
  10. HahnL. The P-R segment in hypertensive heart disease.Heart19402210110610.1136/hrt.2.2.101 18609837
    [Google Scholar]
  11. BenjaminJ.E. The heart disease situation in Cincinnati.Am. Heart J.19272663764810.1016/S0002‑8703(27)90212‑9
    [Google Scholar]
  12. ReidW.D. Some toxic effects of digitalis.JAMA192381643543910.1001/jama.1923.02650060005002
    [Google Scholar]
  13. ReidW.D. The diagnosis of cardiovascular syphilis.Boston Med. Surg. J.1923188718919310.1056/NEJM192302151880701
    [Google Scholar]
  14. DannD.S. Some observations on the value of the index and angle of bordet-vaquez in cardiac examination.Arch. Intern. Med.192331226928810.1001/archinte.1923.00110140121012
    [Google Scholar]
  15. KoracevicG. MićićS. StojanovicM. Significance of beta-blocker in patients with hypertensive left ventricular hypertrophy and myocardial ischemia.Curr. Vasc. Pharmacol.2023212819010.2174/1570161121666230201141215 36722475
    [Google Scholar]
  16. NemtsovaV. BurkardT. VischerA.S. Hypertensive heart disease: A narrative review series part 2: Macrostructural and functional abnormalities.J. Clin. Med.20231217572310.3390/jcm12175723 37685790
    [Google Scholar]
  17. SanchezR.A. AyalaM. BaglivoH. Latin American guidelines on hypertension.J. Hypertens.200927590592210.1097/HJH.0b013e32832aa6d2 19349909
    [Google Scholar]
  18. van den BornB.J. BeutlerJ.J. GaillardC.A. de GooijerA. van den MeirackerA.H. KroonA.A. Dutch guideline for the management of hypertensive crisis -- 2010 revision.Neth. J. Med.2011695248255 21646675
    [Google Scholar]
  19. AronowW.S. FlegJ.L. PepineC.J. ACCF/AHA 2011 expert consensus document on hypertension in the elderly.Circulation2011123212434250610.1161/CIR.0b013e31821daaf6 21518977
    [Google Scholar]
  20. ManciaG. FagardR. NarkiewiczK. 2013 ESH/ESC Guidelines for the management of arterial hypertension.Eur. Heart J.201334282159221910.1093/eurheartj/eht151 23771844
    [Google Scholar]
  21. WolfS.J. LoB. ShihR.D. SmithM.D. FesmireF.M. Clinical policy: Critical issues in the evaluation and management of adult patients in the emergency department with asymptomatic elevated blood pressure.Ann. Emerg. Med.2013621596810.1016/j.annemergmed.2013.05.012 23842053
    [Google Scholar]
  22. The Egyptian Hypertension Society EGYPTIAN HYPERTENSION GUIDELINESEgypt. Heart J.20146627913210.1016/j.ehj.2014.03.001
    [Google Scholar]
  23. JamesP.A. OparilS. CarterB.L. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).JAMA2014311550752010.1001/jama.2013.284427 24352797
    [Google Scholar]
  24. WeberM.A. SchiffrinE.L. WhiteW.B. Clinical practice guidelines for the management of hypertension in the community a statement by the American Society of Hypertension and the International Society of Hypertension.J. Hypertens.201432131510.1097/HJH.0000000000000065 24270181
    [Google Scholar]
  25. SeedatY.K. RaynerB.L. VeriavaY. South African hypertension practice guideline 2014: review article.Cardiovasc. J. Afr.201425628829410.5830/CVJA‑2014‑062 25629715
    [Google Scholar]
  26. TykarskiA. NarkiewiczK. GaciongZ. 2015 guidelines for the management of hypertension. Recommendations of the polish society of hypertension — short version.Kardiol. Pol.201573867670010.5603/KP.2015.0157 26304155
    [Google Scholar]
  27. GabbG.M. MangoniA.A. AndersonC.S. Guideline for the diagnosis and management of hypertension in adults — 2016.Med. J. Aust.20162052858910.5694/mja16.00526 27456450
    [Google Scholar]
  28. MalachiasM.V.B. BarbosaE.C.D. MartimJ.F. RositoG.B.A. ToledoJ.Y. PassarelliO. 7th brazilian guideline of arterial hypertension: chapter 14 - hypertensive crisis.Arq. Bras. Cardiol.20161073Suppl. 3798310.5935/abc.20160164 27819393
    [Google Scholar]
  29. WheltonP.K. CareyR.M. AronowW.S. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults.J. Am. Coll. Cardiol.20187119e127e24810.1016/j.jacc.2017.11.006 29146535
    [Google Scholar]
  30. TayJ.C. SuleA.A. ChewE.K. Ministry of health clinical practice guidelines: hypertension.Singapore Med. J.2018591172710.11622/smedj.2018007 29376186
    [Google Scholar]
  31. Developed by the Division of Non-Communicable Diseases - Ministry of Health2018Kenya national guidelines for cardiovascular diseases managementAvailable from: www.health.go.ke
    [Google Scholar]
  32. South East Sydney Local Health District2018Available from: https://www.seslhd.health.nsw.gov.au/sites/default/files/documents/SESLHDGL068.pdf
  33. Joint committee for guideline revision 2018 chinese guidelines for prevention and treatment of hypertension-a report of the revision committee of chinese guidelines for prevention and treatment of hypertension.J. Geriatr. Cardiol.201916318224110.11909/j.issn.1671‑5411.2019.03.014 31080465
    [Google Scholar]
  34. This new tabular display format follows closely that of the Ministry of Health (MOH) website CPG section.2018Available from: http://www.acadmed.org.my/index.cfm?menuid=67
  35. WilliamsB. ManciaG. SpieringW. 2018 ESC/ESH Guidelines for the management of arterial hypertension.Eur. Heart J.201839333021310410.1093/eurheartj/ehy339 30165516
    [Google Scholar]
  36. LeeH.Y. ShinJ. KimG.H. 2018 korean society of hypertension guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension.Clin. Hypertens.20192512010.1186/s40885‑019‑0124‑x 31388453
    [Google Scholar]
  37. van den BornB.J.H. LipG.Y.H. Brguljan-HitijJ. ESC Council on hypertension position document on the management of hypertensive emergencies.Eur. Heart J. Cardiovasc. Pharmacother.201951374610.1093/ehjcvp/pvy032 30165588
    [Google Scholar]
  38. UmemuraS. ArimaH. ArimaS. The japanese society of hypertension guidelines for the management of hypertension (JSH 2019).Hypertens. Res.20194291235148110.1038/s41440‑019‑0284‑9 31375757
    [Google Scholar]
  39. HuaQ. FanL. LiJ. 2019 Chinese guideline for the management of hypertension in the elderly.J. Geriatr. Cardiol.2019162679910.11909/j.issn.1671‑5411.2019.02.001 30923539
    [Google Scholar]
  40. AlcocerL Álvarez-LópezH Borrayo-SánchezGB Cardona-MuñozEG Chávez-MendozaA Hypertension as a persistent public health problem. A position paper from Alliance for a Healthy Heart, Mexico.Annals of Clinical Hypertension2019310093010.29328/journal.ach.1001015
    [Google Scholar]
  41. ShahS.N. MunjalY.P. KamathS.A. Indian guidelines on hypertension-IV (2019).J. Hum. Hypertens.2020341174575810.1038/s41371‑020‑0349‑x 32427886
    [Google Scholar]
  42. Hypertension in adults: diagnosis and management.2019Available from: www.nice.org.uk/guidance/ng136(Accessed on: 21 November 2023).
  43. Vilela-MartinJ.F. Yugar-ToledoJ.C. RodriguesM.C. Luso-brazilian position statement on hypertensive emergencies - 2020.Arq. Bras. Cardiol.2020114473675110.36660/abc.20190731 32491016
    [Google Scholar]
  44. RabiD.M. McBrienK.A. Sapir-PichhadzeR. Hypertension canada’s 2020 comprehensive guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children.Can. J. Cardiol.202036559662410.1016/j.cjca.2020.02.086 32389335
    [Google Scholar]
  45. BCGuidelines2020Available from: https://www2.gov.bc.ca/gov/content/health/practitioner-professional-resources/bc-guidelines/hypertension
  46. TschanzC.M.P. CushmanW.C. HarrellC.T.E. BerlowitzD.R. SallJ.L. Synopsis of the 2020 U.S. department of veterans affairs/u.s. department of defense clinical practice guideline: the diagnosis and management of hypertension in the primary care setting.Ann. Intern. Med.20201731190491310.7326/M20‑3798 32866417
    [Google Scholar]
  47. WyssF. CocaA. Lopez-JaramilloP. Position statement of the Interamerican Society of Cardiology (IASC) on the current guidelines for the prevention, diagnosis and treatment of arterial hypertension 2017–2020.Int. J. Cardiol. Hypertens.2020610004110.1016/j.ijchy.2020.100041 33447767
    [Google Scholar]
  48. UngerT. BorghiC. CharcharF. 2020 international society of hypertension global hypertension practice guidelines.Hypertension20207561334135710.1161/HYPERTENSIONAHA.120.15026 32370572
    [Google Scholar]
  49. Interim guidelines for the clinical management of hypertension in Jamaica2020Available from: https://www.moh.gov.jm/wp-content/uploads/2020/10/HYPERTENSIONGUIDELINES_Interim_final.pdf
  50. Van MinhH. Van HuyT. LongD.P.P. TienH.A. Highlights of the 2022 vietnamese society of hypertension guidelines for the diagnosis and treatment of arterial hypertension.J. Clin. Hypertens.20222491121113810.1111/jch.14580 36196473
    [Google Scholar]
  51. KimH.L. LeeE.M. AhnS.Y. The 2022 focused update of the 2018 korean hypertension society guidelines for the management of hypertension.Clin. Hypertens.20232911110.1186/s40885‑023‑00234‑9 36788612
    [Google Scholar]
  52. ManciaG. KreutzR. BrunströmM. 2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the european society of hypertension.J. Hypertens.202341121874207110.1097/HJH.0000000000003480 37345492
    [Google Scholar]
  53. IslamS.M.S. Daryabeygi-KhotbehsaraR. GhaffariM.P. Burden of hypertensive heart disease and high systolic blood pressure in australia from 1990 to 2019: results from the global burden of diseases study.Heart Lung Circ.202332101178118810.1016/j.hlc.2023.06.853 37743220
    [Google Scholar]
  54. LuY. LanT. Global, regional, and national burden of hypertensive heart disease during 1990–2019: an analysis of the global burden of disease study 2019.BMC Public Health202222184110.1186/s12889‑022‑13271‑0 35473603
    [Google Scholar]
  55. WestabyJ.D. MilesC. Chis SterI. Characterisation of hypertensive heart disease: pathological insights from a sudden cardiac death cohort to inform clinical practice.J. Hum. Hypertens.202236324625310.1038/s41371‑021‑00507‑6 33654238
    [Google Scholar]
  56. VerdecchiaP. AngeliF. CavalliniC. Sudden cardiac death in hypertensive patients.Hypertension20197351071107810.1161/hypertensionaha.119.12684 30827144
    [Google Scholar]
  57. KoracevicG. PerisicZ. StanojkovicM. A discrepancy: calcium channel blockers are effective for the treatment of hypertensive left ventricular hypertrophy but not as effective for prevention of heart failure.Med. Princ. Pract.202231545446210.1159/000526792 36044874
    [Google Scholar]
  58. EkströmM. HellmanA. HasselströmJ. The transition from hypertension to hypertensive heart disease and heart failure: the PREFERS Hypertension study.ESC Heart Fail.20207273774610.1002/ehf2.12612 32073753
    [Google Scholar]
  59. ScarsoglioS. GualaA. CamporealeC. RidolfiL. Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach.Med. Biol. Eng. Comput.2014521190592010.1007/s11517‑014‑1192‑4 25192922
    [Google Scholar]
  60. SoharaH. AmitaniS. KuroseM. MiyaharaK. Atrial fibrillation activates platelets and coagulation in a time-dependent manner: a study in patients with paroxysmal atrial fibrillation.J. Am. Coll. Cardiol.199729110611210.1016/S0735‑1097(96)00427‑5 8996302
    [Google Scholar]
  61. ChaoT.F. PotparaT.S. LipG.Y.H. Atrial fibrillation: stroke prevention.Lancet Reg. Health Eur.20243710079710.1016/j.lanepe.2023.100797 38362551
    [Google Scholar]
  62. EngaK.F. Rye-HolmboeI. HaldE.M. Atrial fibrillation and future risk of venous thromboembolism: the Tromsø study.J. Thromb. Haemost.2015131101610.1111/jth.12762 25330989
    [Google Scholar]
  63. KoracevicG. StojanovicM. LovicD. ZdravkovicM. SakacD. Certain beta blockers (e.g., bisoprolol) may be reevaluated in hypertension guidelines for patients with left ventricular hypertrophy to diminish the ventricular arrhythmic risk.J. Hum. Hypertens.202135756457610.1038/s41371‑021‑00505‑8 33654234
    [Google Scholar]
  64. OttosenC.I. NadruzW. InciardiR.M. JohansenN.D. FudimM. Biering-SørensenT. Diastolic dysfunction in hypertension: a comprehensive review of pathophysiology, diagnosis, and treatment.Eur. Heart J. Cardiovasc. Imaging202425111525153610.1093/ehjci/jeae178 39018386
    [Google Scholar]
  65. TadicM. CuspidiC. PleinS. Comprehensive assessment of hypertensive heart disease: cardiac magnetic resonance in focus.Heart Fail. Rev.20212661383139010.1007/s10741‑020‑09943‑x 32170529
    [Google Scholar]
/content/journals/cvp/10.2174/0115701611351415241212092014
Loading
/content/journals/cvp/10.2174/0115701611351415241212092014
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test