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- ISSN: 1568-0266
- E-ISSN: 1873-4294
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Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales
- Source: Current Topics in Medicinal Chemistry, Volume 6, Issue 14, Jul 2006, p. 1447 - 1456
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- 01 Jul 2006
Abstract
Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.
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