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Abstract

Introduction

The genus (Apocynaceae), comprising approximately 16 species distributed in tropical and subtropical regions, is widely used in Southeast Asian and South American traditional medicine. Rich in terpenoids, flavonoids, and phenolics, it exhibits broad pharmacological potential. This review provides a comprehensive summary of the ethnobotany, phytochemistry, and therapeutic relevance of to guide future research and drug development.

Methods

An extensive literature survey was conducted up to May 2025 using databases including SciFinder, PubMed, Scopus, and Google Scholar by using keywords such as , Phytochemistry, Pharmacological activity, and Ethnobotany.

Results

Across the genus, a total of 209 compounds have been reported, predominantly terpenoids, followed by phenolics and volatiles. Preclinical studies have highlighted the antioxidant, antimicrobial, anti-inflammatory, antiviral, antifertility, wound-healing, and cytotoxic activities of , supporting it as a promising source of new therapeutics.

Discussion

The rich phytochemical profile and broad pharmacology position as a valuable ethnomedicinal resource with potential for modern drug discovery. However, the majority of studies are limited to preclinical studies, with minimal clinical validation and restricted species diversity. Future research should focus on chemical profiling, clinical trials, and safety assessment.

Conclusion

offers a diverse array of bioactive compounds with significant pharmacological relevance. By integrating traditional uses with scientific evidence, this review highlights the potential of ethnomedicine in bridging the gap between traditional and modern pharmacology, while underscoring the need for future research on unexplored species.

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2026-01-31

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References

  1. Process for single-step biosynthesis of iron oxide nanoparticles of Allamanda cathartica. I.N. Patent 202311065457 A, 2023
    [Google Scholar]
  2. Seikh J. Owary J. Flower waste as a potential substrate for biosurfactant production. Res. J. Biotechnol. 2023 18 12 71 79 10.25303/1812rjbt071079
    [Google Scholar]
  3. Saikia S. Saud B.K. Dutta P. Baruah S. Gogoi A.K. Green synthesis and characterization of copper nanoparticles using different plant sources. Int. J. Plant Soil Sci. 2023 35 3 37 45 10.9734/ijpss/2023/v35i32768
    [Google Scholar]
  4. Ramanan D. John P.P. Shaju N. Mathews M.S. Allamanda cathartica: The yellow bloom; an overview of pharmacological activities. World J. Pharm. Pharm. Sci. 2023 12 3 665 673 10.20959/wjpps20233‑24390
    [Google Scholar]
  5. Method for preparing silver nanoparticles from Allamanda neriifolia and evaluating anti-cytotoxic activity. I.N. Patent 202211045418 A 2022
    [Google Scholar]
  6. Subramanian K. Vijayakumar V. Thermal analysis of cellulosic stalk (stem) fiber from the ornamental Allamanda Blanchetii plant for commercial exploitations. Carbohydr Polym. Technol Appl. 2021 2 100069 10.1016/j.carpta.2021.100069
    [Google Scholar]
  7. Sarkar R.D. Kalita M.C. Se nanoparticles stabilized with Allamanda cathartica L. flower extract inhibited phytopathogens and promoted mustard growth under salt stress. Heliyon 2022 8 3 e09076 10.1016/j.heliyon.2022.e09076 35299604
    [Google Scholar]
  8. Okwubie L. Chukwudi C. Evaluation of the antimicrobial activity of the crude root extracts of Allamanda cathartica L (Apocynaceae). Pharma Innov. 2017 6 12 88 92
    [Google Scholar]
  9. Otero R. Núñez V. Barona J. Fonnegra R. Jiménez S.L. Osorio R.G. Saldarriaga M. Díaz A. Snakebites and ethnobotany in the northwest region of Colombia. J. Ethnopharmacol. 2000 73 1-2 233 241 10.1016/S0378‑8741(00)00321‑4 11025161
    [Google Scholar]
  10. Ogbole O.O. Akinleye T.E. Nkumah A.O. Awogun A.O. Attah A.F. Adewumi M.O. Adeniji A.J. In vitro antiviral activity of peptide-rich extracts from seven Nigerian plants against three non-polio enterovirus species C serotypes. Virol. J. 2021 18 1 161 10.1186/s12985‑021‑01628‑7 34348755
    [Google Scholar]
  11. Pamidimukkala K. Prabhudas N. Nandini H.h. Kutty A.V.M. Allamanda cathartica L. latex mediated magnesium oxide nanoparticles as antiproliferative agents. Nanomed Res. J. 2021 6 3 257 268 10.22034/nmrj.2021.03.006
    [Google Scholar]
  12. Hasan I. Hussain M.S. Millat M.S. Sen N. Rahman M.A. Rahman M.A. Islam S. Moghal M.M.R. Ascertainment of pharmacological activities of Allamanda neriifolia Hook and Aegialitis rotundifolia Roxb used in Bangladesh: An in vitro study. J. Tradit. Complement. Med. 2018 8 1 107 112 10.1016/j.jtcme.2017.03.005 29321997
    [Google Scholar]
  13. Bhatnagar S. Das R. Antioxidant, cytotoxic and phytochemical assessment of leaf extracts of golden trumpet (Allamanda catharticaL.). World J. Pharm. Res. 2017 6 6 1346 1355 10.20959/wjpr20176‑8661
    [Google Scholar]
  14. Omonhinmin A.C. Dike I.P. Rotimi S.O. Phytochemical, cytotoxicity and antioxidant activities of five anti-malaria plants. Res. J. Med. Plant 2015 9 2 81 89 10.3923/rjmp.2015.81.89
    [Google Scholar]
  15. Sharmin T. Sarker P.K. Islam F. Chowdhury S.R. Quadery T.M. Mian M.Y. Ashikur Rahman S.M. Chowdhury Z.S. Ullah M.S. Investigation of biological activities of Allamanda blanchetii, the violet Allamanda. J. Pharm. Res. 2013 6 7 761 764 10.1016/j.jopr.2013.07.010
    [Google Scholar]
  16. Nascimento F.G. Faqueti A. Wilhelm J.F. Wittkowski C. Tomczak F.D. Borges S.L. Yunes R.A. Franchi G.C. Nowill A.E. Filho V.C. Machado M.S. de Freitas R.A. Malheiros A. Seasonal influence and cytotoxicity of extracts, fractions and major compounds from Allamanda schottii. Rev. Bras. Farmacogn. 2014 24 5 545 552 10.1016/j.bjp.2014.08.005
    [Google Scholar]
  17. Haron F.F. Sijam K. Omar D. Rahmani M. Chemical composition and screening for antifungal activity of Allamanda spp. (Apocynaceae) crude extracts against Colletotrichum gloeosporioides, causal agent of anthracnose in papaya. Aust. J. Basic Appl. Sci. 2013 7 1 88 96
    [Google Scholar]
  18. Chinese academy of tropical agricultural sciences. C.N. Patent 101669526 A 2010
    [Google Scholar]
  19. Sultana H. Chetia A. Saikia A. Khan N.J. An updated review on extraction, isolation, and identification of bioactive compounds from plant extracts. Schol Acad. J. Pharm. 2023 12 7 154 171 10.36347/sajp.2023.v12i07.001
    [Google Scholar]
  20. Antitumor Chinese medicine composition and its production method. CN Patent 106943544 A 2017
    [Google Scholar]
  21. Chaveerach A. Tanee T. Patarapadungkit N. Khamwachirapithak P. Sudmoon R. Cytotoxicity and genotoxicity of Allamanda and Plumeria species. Sci. Asia 2016 42 6 375 10.2306/scienceasia1513‑1874.2016.42.375
    [Google Scholar]
  22. Bresciani F.R. Santi L. Beys-da-Silva W.O. Berger M. Barcellos V.A. Schripsema J. von Poser G.L. Guimarães J.A. Vainstein M.H. Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp. Arch. Pharm. (Weinheim) 2020 353 10 2000133 10.1002/ardp.202000133 32638423
    [Google Scholar]
  23. Chaveerach A. Aungkapattamagul S. Tanee T. Noikotr K. Sudmoon R. Genetic verification and chemical contents identification of Allamanda species (Apocynaceae). Pak. J. Pharm. Sci. 2014 27 3 417 424 24811796
    [Google Scholar]
  24. Jia L. Review on chemical constituents of Allemanda. Zhongguo Xin Yao Zazhi 2006 15 16 1341 1344
    [Google Scholar]
  25. Carballeira N.M. Cruz C. 5,9-Nonadecadienoic acids in Malvaviscus arboreus and Allamanda cathartica. Phytochemistry 1998 49 5 1253 1256 10.1016/S0031‑9422(98)00111‑3
    [Google Scholar]
  26. Ghosh C. Hazra L. Nag S.K. Sil S. Dutta A. Biswas S. Biswas M. Ghosh P. Chatterjee S. Allamanda cathartica Linn. Apocynaceae: A mini review. Int. J. Herb. Med. 2019 7 4 29 33
    [Google Scholar]
  27. Cabugatan M.A.D. Ong R.L.J.T. Mancao L.S. Lumogdang L.P. Ethnobotanical survey on medicinal plants used by the Manobo Tribe of Don Marcelino, Davao Occidental, Philippines. Asian. J. Biol. Life Sci. 2022 11 2 492 504 10.5530/ajbls.2022.11.67
    [Google Scholar]
  28. Petricevich V.L. Abarca-Vargas R. Allamanda cathartica: A review of the phytochemistry, pharmacology, toxicology, and biotechnology. Molecules 2019 24 7 1238 10.3390/molecules24071238 30934947
    [Google Scholar]
  29. Haque M.M. Choudhury M.S. Hossain M.S. Haque M.A. Syeda Seraj S.S. Mohammed Rahmatullah M.R. Ethnographic information and medicinal formulations of a Mro community of Gazalia Union in the Bandarbans district of Bangladesh. American Eurasian J. Sust Agricult 2012 6 3 162 171
    [Google Scholar]
  30. Deepan T. Srilekha S. Dhanaraju M. Alekhya V. Preliminary phytochemical analysis and comparitive study of Allamanda blanchetti and Allamanda cathartica by chick emesis model. Int. J. Chem. Pharm. Sci. 2016 7 48 51
    [Google Scholar]
  31. Sumathi R. Anuradha R. Protective role of methanolic flower extract of A llamanda neriifolia hook against 1, 4 dichlorobenzene (dcb)-induced hepatotoxicity. Indo American J. Pharm. Sci. 2017 4 12 4804 4809 10.5281/ZENODO.1134386
    [Google Scholar]
  32. Silva e Souza E. Barcellos V.A. Sbaraini N. Reuwsaat J.C.V. Schneider R.O. da Silva A.C. Garcia A.W.A. von Poser G.L. Barbosa E.G. Lima J.P.M.S. Vainstein M.H. A Plumieridine-Rich fraction from Allamanda polyantha inhibits chitinolytic activity and exhibits antifungal properties against Cryptococcus neoformans. Front. Microbiol. 2020 11 2058 10.3389/fmicb.2020.02058 32983042
    [Google Scholar]
  33. Nwandu C.J. Nyananyo B.L. Ozimede C.O. Phytochemical screening of leaf extracts of eleven selected tropical plants species from eastern and southern Nigeria. J. Appl. Sci. Environ. Manag. 2019 23 10 1867 1873 10.4314/jasem.v23i10.16
    [Google Scholar]
  34. Janete H. Yariwake V. Elayse H.M. Marcos G. Adriana B. Marcia A.G.C. Valeria L.B.C. Antifungal compounds from Apocynaceae species. Rev. Latinoam. Quím. 1995 23 2 73 75
    [Google Scholar]
  35. Abe F. Yamauchi T. 9α-hydroxypinoresinol, 9α-hydroxymedioresinol and related lignans from Allamanda neriifolia. Phytochemistry 1988 27 2 575 577 10.1016/0031‑9422(88)83144‑3
    [Google Scholar]
  36. Pawar K.P. Bhitre M.J. Kalamkar P.V. Kale M.K. Pharmacognostical studies on leaves of Allamanda cathartica with detail physicochemical and phytochemical evaluation. Res. J. Pharm. Phytoch 2015 7 2 69 72 10.5958/0975‑4385.2015.00013.8
    [Google Scholar]
  37. Sethi A. Prakash R. Identification of phytochemical constituents from biologically active pet ether and chloroform extracts of the flowers of Allamanda violacea A.DC (Apocynaceae). J. Plant Sci. Res. 2013 3 4 95 108
    [Google Scholar]
  38. Shen Y.C. Chen C.H. Allaneroside and bioactive iridoid glycosides from Allamanda neriifolia. Taiwan Yaoxue Zazhi 1986 38 4 203 213
    [Google Scholar]
  39. Oluwasegun A. Nasiru A. John E. In-vitroantioxidant potential of methanol extracts of Allamanda schottii Pohl and Thevetia peruviana (pers.) K. (Apocyanaceae). Asian J. Plant. Sci. Res. 2015 5 1 10 13
    [Google Scholar]
  40. Joselin J. Brintha T.S.S. Florence A.R. Jeeva S. Screening of select ornamental flowers of the family Apocynaceae for phytochemical constituents. Asian Pac. J. Trop. Dis. 2012 2 S260 S264 10.1016/S2222‑1808(12)60162‑5
    [Google Scholar]
  41. Anderson J.E. Chang C.J. McLaughlin J.L. Bioactive components of Allamanda schottii. J. Nat. Prod. 1988 51 2 307 308 10.1021/np50056a018 3379414
    [Google Scholar]
  42. Augustus G.D.P.S. Seiler G.J. Phytochemicals of selected plant species of the Apocynaceae and Asclepiadaceae from Western Ghats, Tamil Nadu, India. Biomass Bioenergy 2011 35 7 3012 3017 10.1016/j.biombioe.2011.03.043
    [Google Scholar]
  43. Jewers K. Manchanda A.H. Castillo A.V. Constituents of Allamanda cathartica. Asian J. Pharm. 1971 2 1 5 8
    [Google Scholar]
  44. Bonomini T. Góes J. Machado M. Silva R. Malheiros A. Development and optimization of a microwave-assisted extraction of plumieride from Allamanda cathartica L. Flowers. Quim. Nova 2017 41 36 42 10.21577/0100‑4042.20170153
    [Google Scholar]
  45. Muller A.F.F. Silva D.C.S. MacDonald R. Bonomini T.J. Da S. Establishment of an HPLC-PDA method for analysis of derivative products from the flowers of Allamanda cathartica. J. Chem. Pharm. Res. 2015 7 10 250 256
    [Google Scholar]
  46. Mone M. Saieed M.A.U. Dastogeer K.M.G. Ali M.A. Meah M.B. Plumieride from Allamanda cathartica as an inhibitory compound to plant pathogenic fungi. Arch. Phytopathol. Pflanzenschutz 2014 47 11 1311 1326 10.1080/03235408.2013.840103
    [Google Scholar]
  47. Yamauchi K. Mitsunaga T. Batubara I. Isolation, identification and tyrosinase inhibitory activities of the extractives from Allamanda cathartica. Nat. Resour. 2011 2 3 167 172 10.4236/nr.2011.23022
    [Google Scholar]
  48. Malheiros A. Schuquel I.T. Vidotti G. Complete assignments of chemical shifts of the hydrogen and carbon-13 atoms of plumieride isolated from Allamanda cathartica. Quim. Nova 1997 20 457 459 10.1590/S0100‑40421997000500002
    [Google Scholar]
  49. Yu Y.L. Li X. Ke C.Q. Tang C.P. Yang X.Z. Li X.Q. Ye Y. Iridoid glucosides from Allamanda neriifolia. Chin. Chem. Lett. 2010 21 6 709 711 10.1016/j.cclet.2010.02.007
    [Google Scholar]
  50. Ganapaty S. Rao D.V. Venkata R.D. Chemical constituents of flowers of Allamanda schottii Pohl. Indian J. Pharm. Sci. 1988 50 2 134 135
    [Google Scholar]
  51. Abe F. Mori T. Yamauchi T. Iridoids of apocynaceae. III. Minor iridoids from Allamanda neriifolia. Chem. Pharm. Bull. 1984 32 8 2947 2956 10.1248/cpb.32.2947
    [Google Scholar]
  52. Coppen J.J.W. Iridoids with algicidal properties from Allamanda cathartica. Phytochemistry 1983 22 1 179 182 10.1016/S0031‑9422(00)80083‑7
    [Google Scholar]
  53. Bantval R.P. Subramaniam P.S. Rao U.R. Isolation of plumericin and isoplumericin from Allamanda cathartica. Indian J. Chem. 1970 8 9 851
    [Google Scholar]
  54. Khanam M.N. Anis M. Ahmad S. Establishment of adventitious root cultures of Allamanda cathartica L. for the production of iridoid glycosides and its identification using HPTLC MS. Ind. Crops Prod. 2018 125 198 206 10.1016/j.indcrop.2018.08.044
    [Google Scholar]
  55. Abdel-Kader M.S. Wisse J. Evans R. van der Werff H. Kingston D.G.I. Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest. J. Nat. Prod. 1997 60 12 1294 1297 10.1021/np970253e 9428163
    [Google Scholar]
  56. Yamauchi T. Abe F. Taki M. Protoplumericin, an iridoid bis-glucoside in Allamanda neriifolia. Chem. Pharm. Bull. 1981 29 10 3051 3055 10.1248/cpb.29.3051
    [Google Scholar]
  57. Bhattacharyya J. De Morais M.D.S.Q. 5, 6-Dimethoxy-7-hydroxycoumarin (Umckalin) from Allamanda blanchetti: Isolation and 13C-NMR characteristics. J. Nat. Prod. 1986 49 2 354 355 10.1021/np50044a032
    [Google Scholar]
  58. Yariwake Vilegas J.H. Hachich E.M. Garcia M. Brasileiro A. Antifungal compounds from Apocynaceae species. Rev. Latinoam. Quím. 1992 23 1 44 45
    [Google Scholar]
  59. Haron F.F. Sijam K. Omar D. Rahmani M. Bioassay-guided isolation of antifungal plumericin from Allamanda species (Apocynaceae). J. Biol. Sci. 2013 13 3 158 162 10.3923/jbs.2013.158.162
    [Google Scholar]
  60. Coppen J.J.W. Cobb A.L. The occurrence of iridoids in Plumeria and Allamanda. Phytochemistry 1983 22 1 125 128 10.1016/S0031‑9422(00)80071‑0
    [Google Scholar]
  61. Kupchan S.M. Dessertine A.L. Blaylock B.T. Bryan R.F. Isolation and structural elucidation of allamandin, and antileukemic iridoid lactone from allamanda cathartica. J. Org. Chem. 1974 39 17 2477 2482 10.1021/jo00931a001 4414009
    [Google Scholar]
  62. De Melo S.J. De Mello J.F. Desmethylplumericin from Allamanda cathartica. Fitoterapia 1997 68 5 478
    [Google Scholar]
  63. Jewers K. Coppen J.J.W. Manchanda A.H. Paisley H.M. Castillo A. Biologically active lactones of Allamanda cathartica. Pahlavi Med. J. 1975 6 1 52 62
    [Google Scholar]
  64. Parkes K.E.B. Pattenden G. Total synthesis of (±)-allamcin. An approach TC antileukaemic iridoid lactones. Tetrahedron Lett. 1986 27 11 1305 1308 10.1016/S0040‑4039(00)84244‑6
    [Google Scholar]
  65. Method for extracting total lactones from Allamanda neriifolia. CN Patent 102824384 A 2012
    [Google Scholar]
  66. Supercritical extraction of allamandicin from Allamanda neriifolia root. CN Patent 102850373 A 2013
    [Google Scholar]
  67. Ragasa C.Y. Alimboyoguen A.B. Long chain 4-hydroxycinnamate esters from Allamanda neriifolia Hook. American. Journal of Essential. Oils Natural Product 2013 1 50 53
    [Google Scholar]
  68. Maia J.G.S. Zoghbi M.G.B. Andrade E.H.A. Carreira L.M.M. Volatiles from flowers of Thevetia Peruviana (pers.) k. Schum. and Allamanda cathartica linn.(Apocynaceae). J. Essent. Oil Res. 2000 12 3 322 324 10.1080/10412905.2000.9699526
    [Google Scholar]
  69. Báez D. Pino J.A. Morales D. Scent composition from flowers of Allamanda cathartica L. from Cuba. J. Essent. Oil-Bear. Plants 2012 15 1 12 14 10.1080/0972060X.2012.10644013
    [Google Scholar]
  70. Abinaya D. Harshini J. Narayanan N. Manikandan D. SenthilKumar, D. Solvent extraction and characterization of essential oil from Allamanda voilacea. IOP Conf. Series Mater. Sci. Eng. 2020 955 1 012086 10.1088/1757‑899X/955/1/012086
    [Google Scholar]
  71. Mishra R.K. Singh S. Singh S.K. Natural products in regulation of male fertility. Indian J. Med. Res. 2018 148 1 S107 S114.(Suppl. 1) 10.4103/ijmr.IJMR_1968_17 30964087
    [Google Scholar]
  72. Chan E.W.C. Soon C.Y. Tan J.B.L. Wong S.K. Hui Y.W. Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells. J. Integr. Med. 2019 17 3 155 160 10.1016/j.joim.2019.03.003
    [Google Scholar]
  73. Ganapaty S. Rao D.V. Akihisa T. Matsumoto T. Diosgenin and other constituents of the flowers of Allamanda blanchetii A. DC. Indian J. Pharm. Sci. 1989 51 6 256 258
    [Google Scholar]
  74. Matida A.K. Rossi M.H. Blumenthal E.D.A. Schuquel I.T.A. Malheiros A. Vidotti G.J. 3-β-O-β-D-glucopyranosylsitosterol in species of Labiatae. Verbenaceae and Apocynaceae. Ann Brazil Chem. Asso 1996 45 3 147 151
    [Google Scholar]
  75. Sethi A. Prakash R. Srivastava S. Amandeep; Bishnoi, A.; Singh, R.P. Isolation of brassicasterol, its synthetic prodrug-crystal structure, stereochemistry and theoretical studies. J. Mol. Struct. 2014 1070 28 37 10.1016/j.molstruc.2014.04.017
    [Google Scholar]
  76. Sethi A. Prakash R. Novel synthetic ester of Brassicasterol, DFT investigation including NBO, NLO response, reactivity descriptor and its intramolecular interactions analyzed by AIM theory. J. Mol. Struct. 2015 1083 72 81 10.1016/j.molstruc.2014.11.028
    [Google Scholar]
  77. Bonomini T.J. Wittkowski C. Tomczak F.D. Mafra M.M. Mattos P.D. Yunes R.A. Filho V.C. Machado D.S.M. Lucinda R.M. Malheiros A. Development and validation of an HPLC-PDA method for the determination of flavonoids in Allamanda species flowers. J. Chem. Pharm. Res. 2015 7 2 409 415
    [Google Scholar]
  78. Hema K. Sukumar D. Isolation and phytochemical studies of quercetin and quercetin 3-o-rhamnoside. Int. J. Pharma Bio Sci. 2013 4 4 519 524
    [Google Scholar]
  79. Manogaran S. Sulochana N. Extraction and characterization of Allamanda cathartica. Asian J. Chem. 2005 17 3 1955 1958
    [Google Scholar]
  80. Li A.N. Li S. Li H.B. Xu D.P. Xu X.R. Chen F. Total phenolic contents and antioxidant capacities of 51 edible and wild flowers. J. Funct. Foods 2014 6 319 330 10.1016/j.jff.2013.10.022
    [Google Scholar]
  81. Extraction of allamandicin from leaf of Allamanda neriifolia. CN Patent CN104447788 A 2015
    [Google Scholar]
  82. Wong S. Lim Y. Abdullah N. Nordin F. Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species. Pharmacognosy Res. 2011 3 2 100 106 10.4103/0974‑8490.81957 21772753
    [Google Scholar]
  83. Fartyal M. Padma K. Pharmacological evaluation of crude extracts of Allamanda cathartica linn. extracted in polar and non-polar solvents. Int. J. Curr. Res. 2016 8 08 35730 35735
    [Google Scholar]
  84. Fartyal M. Kumar P. Evaluation of antimicrobial efficacy of alkaloids, flavonoids and steroids of Allamanda cathartica Linn. against some pathogenic bacteria. Int. J. Adv. Pharm. Biol. Chem. 2016 5 303 313
    [Google Scholar]
  85. Bargah R.K. Jain S.K. Markande S.K. Tandon S.K. Diwan M. Singh H. Evaluation of phytochemical screening antioxidant using By DPPH, H2O2 methods and antibacterial activity of the crude flower extracts of Allamanda cathartica L. (Apocynaceae). Inter J. Curr. Res. Chem. Pharm. Sci. 2024 11 7 39 51 10.22192/ijcrcps
    [Google Scholar]
  86. Karunakaran G. Jagathambal M. Gusev A. Kolesnikov E. Mandal A.R. Kuznetsov D. Allamanda cathartica flower’s aqueous extract-mediated green synthesis of silver nanoparticles with excellent antioxidant and antibacterial potential for biomedical application. MRS Commun. 2016 6 1 41 46 10.1557/mrc.2016.2
    [Google Scholar]
  87. Rao M.L. G, B.; N, S. Green synthesis of silver nanoparticles by Allamanda cathartica L. leaf extract and evaluation for antimicrobial activity. Inter J. Curr. Res. Chem. Pharm. Sci. 2013 6 4 2260 2268 10.37285/ijpsn.2013.6.4.9
    [Google Scholar]
  88. VP VP S.; ER, R.; Vijayan, U.S.; Panicker, L. Green synthesis zinc oxide nanoparticle using Allamanda cathartica leaf extract and their cytotoxic and antibacterial activity. Nanomed Res. J. 2020 5 3 298 305 10.22034/nmrj.2020.03.010
    [Google Scholar]
  89. Nazifa Z. Aminuzzaman F.M. Laila L. Rehena M.K. In vitroefficacy of botanicals against rice blast pathogen Magnaporthe oryzae oryzae. Am. J. Plant Sci. 2021 12 4 662 678 10.4236/ajps.2021.124045
    [Google Scholar]
  90. Rehena M.K. Aminuzzaman F.M. Ashrafi M.L. Chowdhury M.S.M. Habiba U.A. Nazifa Z. Ahmed M. Efficacy of ethanol extract of botanicals in controlling wheat blast fungus Magnaporthe oryzae triticum in vitro. Nepal J. Biotechnol. 2022 10 2 77 84 10.54796/njb.v10i2.241
    [Google Scholar]
  91. Tripathi P. Efficacies of botanicals in the management of stem end rot disease of mango fruits. J. Biopesticides 2022 15 1 01 08 10.57182/jbiopestic.15.1.01‑08
    [Google Scholar]
  92. Tomar R. Das S.S. Sahu V. Kapoor N. Chaudhary D. Sahoo J. Rath S.K. Kesari K.K. Allamanda cathartica (Linn.) leaf extract-encapsulated phytoemulsions: Formulation, characterization and in vitro – in vivo biological evaluations. Sustainable Food. Technology 2024 2 5 1490 1505 10.1039/D4FB00077C
    [Google Scholar]
  93. Kumar S. Bhattacharyya A. Savani A.K. Gogoi S. Antifungal activity of some local botanicals of Assam against Pythium aphanidermatum inciting storage rot of ginger. Int. J. Curr. Microbiol. Appl. Sci. 2019 8 11 528 535 10.20546/ijcmas.2019.811.065
    [Google Scholar]
  94. Fartyal M. Allamanda cathartica linn.: Extraction and pharmaceutical evaluation of various extracts of leaves and flowers. Int. J. Curr. Pharm. Res. 2016 8 4 28 31 10.22159/ijcpr.2016v8i4.15272
    [Google Scholar]
  95. Fartyal M. Comparative study of antifungal potential of various extracts of leaves of Carissa carandas Linn., Nerium oleander Linn. and Allamanda cathartica Linn. against human fungal pathogen Candida albicans. Vegetos 2023 37 5 1847 1854 10.1007/s42535‑023‑00756‑5
    [Google Scholar]
  96. Nahar A. Ashrafuzzaman S. Islam M.N. Alam M.S. Studies on antidermatophytic effect of Allamanda cathertica. Bangladesh J. Pharmacol. 2010 5 1 5 7 10.3329/bjp.v5i1.4610
    [Google Scholar]
  97. Tiwari T.N. Pandey V.B. Dubey N.K. Plumieride from Allamanda cathartica as an antidermatophytic agent. Phytother. Res. 2002 16 4 393 394 10.1002/ptr.967 12112301
    [Google Scholar]
  98. Filho V.C. Meyre-Silva C. Niero R. Bolda Mariano L.N. Gomes do Nascimento F. Vicente Farias I. Gazoni V.F. dos Santos Silva B. Giménez A. Gutierrez-Yapu D. Salamanca E. Malheiros A. Evaluation of antileishmanial activity of selected brazilian plants and identification of the active principles. Evid. Based Complement. Alternat. Med. 2013 2013 1 7 10.1155/2013/265025 23840252
    [Google Scholar]
  99. Tomar R. Mishra S.S. Sahoo J. Rath S.K. Computational and in-vitro investigation of phytochemicals from Allamanda cathartica as a potential candidate for the treatment of type 2 Diabetes mellitus. J. Comput. Bioph Chem. 2024 23 7 901 923 10.1142/S2737416524500194
    [Google Scholar]
  100. de Souza P. de Sales P. Simeoni L. Silva E. Silveira D. de Oliveira Magalhães P. Inhibitory activity of α-amylase and α-glucosidase by plant extracts from the Brazilian cerrado. Planta Med. 2012 78 4 393 399 10.1055/s‑0031‑1280404 22134849
    [Google Scholar]
  101. Singh A. Singh S.K. Reversible antifertility effect of aqueous leaf extract of Allamanda cathartica L. in male laboratory mice. Andrologia 2008 40 6 337 345 10.1111/j.1439‑0272.2008.00866.x 19032682
    [Google Scholar]
  102. Kiruthika S.A. Sornaraj R. Comparative study on the spermicidal activity of datura metal and Allamanda cathartica flower extracts. World J. Pharm. Res. 2017 7 4 593 604 10.20959/wjpr20184‑10821
    [Google Scholar]
  103. Gupta R.S. Bhatnager A.K. Joshi Y.C. Sharma R. Sharma A. Effects of Plumieride, an iridoid on spermatogenesis in male albino rats. Phytomedicine 2004 11 2-3 169 174 10.1078/0944‑7113‑00346 15070168
    [Google Scholar]
  104. Rehan S. Tasnuva S. Farhana I. Sharmin R.C. In vitro antioxidant, total phenolic, membrane stabilizing and antimicrobial activity of Allamanda cathartica L.: A medicinal plant of Bangladesh. J. Med. Plants Res. 2014 8 1 63 67 10.5897/JMPR12.1273
    [Google Scholar]
  105. Hema K. In-vitro anti-inflammatory activity of quercitrin isolated from Allamanda cathartica linn. Int. J. Pharma Bio Sci. 2014 5 4 440 445
    [Google Scholar]
  106. Vyas A. Gupta R. Jatav R. In-vitro antioxidant and in-vivo analgesics and anti-inflammatory activity of Allamanda blanchetii leaf extract in rats. Antiinflamm. Antiallergy Agents Med. Chem. 2025 24 2 114 126 10.2174/0118715230340178241008163943 39681830
    [Google Scholar]
  107. Bagde M.P. Sahu D. Chaudhary L. Patel S. Gamit A. Evaluation of the anti-inflammatory and analgesic activity of Allamanda blanchetii (Apocynaceae). J. Pharm. Adv. Res. 2024 7 7 2302 2308
    [Google Scholar]
  108. Agbo M.O. Uzor P.F. Akazie Nneji U.N. Eze Odurukwe C.U. Ogbatue U.B. Mbaoji E.C. Antioxidant, total phenolic and flavonoid content of selected Nigerian medicinal plants. Dhaka Unive J. Pharm. Sci. 2015 14 1 35 41 10.3329/dujps.v14i1.23733
    [Google Scholar]
  109. Hameed A. Nawaz G. Gulzar T. Chemical composition, antioxidant activities and protein profiling of different parts of Allamanda cathartica. Nat. Prod. Res. 2014 28 22 2066 2071 10.1080/14786419.2014.923997 24931146
    [Google Scholar]
  110. Gangwar R.K. Dhumale V.A. Gosavi S.W. Sharma R.B. Datar S.S. Catalytic activity of allamanda mediated phytosynthesized anisotropic gold nanoparticles. AAdv Nat. Sci. Nanosci Nanotech 2013 4 4 045005 10.1088/2043‑6262/4/4/045005
    [Google Scholar]
  111. Conrad O.A. Dike I.P. Agbara U. In vivo antioxidant assessment of two antimalarial plants– Allamamda cathartica and Bixa orellana. Asian Pac. J. Trop. Biomed. 2013 3 5 388 394 10.1016/S2221‑1691(13)60082‑9 23646303
    [Google Scholar]
  112. Ghosh C. Banerjee S. Floral extracts of Allamanda blanchetii and Allamanda cathartica are comparatively higher resource of anti-oxidants and polysaccharides than leaf and stem extracts. Int. J. Curr. Pharm. Res. 2018 10 4 36 10.22159/ijcpr.2018v10i4.28458
    [Google Scholar]
  113. Fu L. Xu B.T. Xu X.R. Qin X.S. Gan R.Y. Li H.B. Antioxidant capacities and total phenolic contents of 56 wild fruits from South China. Molecules 2010 15 12 8602 8617 10.3390/molecules15128602 21116229
    [Google Scholar]
  114. Müller V. Chávez J.H. Reginatto F.H. Zucolotto S.M. Niero R. Navarro D. Yunes R.A. Schenkel E.P. Barardi C.R.M. Zanetti C.R. Simões C.M.O. Evaluation of antiviral activity of South American plant extracts against herpes simplex virus type 1 and rabies virus. Phytother. Res. 2007 21 10 970 974 10.1002/ptr.2198 17604374
    [Google Scholar]
  115. Suryawanshi R. Patil C. Borase H. Narkhede C. Patil S. Screening of Rubiaceae and Apocynaceae extracts for mosquito larvicidal potential. Nat. Prod. Res. 2015 29 4 353 358 10.1080/14786419.2014.941362 25317964
    [Google Scholar]
  116. Sarker R. Sharmin T. Chowdhury S.R. Islam F. Thrombolytic activity and preliminary cytotoxicity of five different fractions of methanol extract of Allamanda cathartica leaf. J. Appl. Pharm. Sci. 2012 2 7 129 132 10.7324/JAPS.2012.2717
    [Google Scholar]
  117. Nelaturi P.D. Sriramaiah N.H. Nagaraj S. Kotakadi V.S. Kutty A.V.V.M. Pamidimukkala K. An in-vitro cytotoxic and genotoxic properties of Allmanda Cathartica L. latex green NPs on human peripheral blood mononuclear cells. Nano Biomed. Eng. 2017 9 4 314 323 10.5101/nbe.v9i4.p314‑323
    [Google Scholar]
  118. de F Navarro Schmidt de F Navarro Schmidt D.; Yunes, R.A.; Schaab, E.H.; Malheiros, A.; Cechinel Filho, V.; Franchi, G.C.; Nowill, A.E.; Cardoso, A.A.; Yunes, J. Evaluation of the anti-proliferative effect the extracts of Allamanda blanchetti and A. schottii on the growth of leukemic and endothelial cells. J. Pharm. Pharm. Sci. 2006 9 2 200 208 16959189
    [Google Scholar]
  119. Application of allamcin in preparation of anti-tumor drugs. CN Patent 104042608 2014
    [Google Scholar]
  120. Dalmagro A.P. Camargo A. Zimath P.L. Bonomini T.J. Zeni A.L.B. Malheiros A. de Souza M.M. Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems. Nat. Prod. Res. 2021 35 22 4849 4852 10.1080/14786419.2020.1737052 32159400
    [Google Scholar]
  121. Bonomini T.J. Holzmann I. Thiesen L.C. Fratoni E. Muller A.F.F. Lucinda-Silva R.M. Yunes R.A. Malheiros A. Gonçalves A.E. Dalmagro A.P. da Silva K.A.B.S. de Souza M.M. Santin J.R. Neuropharmacological and acute toxicological evaluation of ethanolic extract of Allamanda cathartica L. flowers and plumieride. Regul. Toxicol. Pharmacol. 2017 91 9 19 10.1016/j.yrtph.2017.10.005 28986178
    [Google Scholar]
  122. Alen Y. Nakajima S. Nitoda T. Baba N. Kanzaki H. Kawazu K. Antinematodal activity of some tropical rainforest plants against the pinewood nematode, Bursaphelenchus xylophilus. Z. Naturforsch. C J. Biosci. 2000 55 3-4 295 299 10.1515/znc‑2000‑3‑425 10817223
    [Google Scholar]
  123. Nayak S. Nalabothu P. Sandiford S. Bhogadi V. Adogwa A. Evaluation of wound healing activity of Allamanda cathartica. L. and Laurus nobilis. L. extracts on rats. BMC Complement. Altern. Med. 2006 6 1 12 10.1186/1472‑6882‑6‑12 16597335
    [Google Scholar]
  124. Dogiparthi L.K. Jain S.K. Design and characterization of Allamanda cathartica based ointment for its wound healing property. J. Glob. Trends Pharm. Sci. 2018 9 3 5786 5791
    [Google Scholar]
  125. Sumathi R. Anuradha R. Hepatoprotective effect of Allamanda neriifolia hook on 1, 4 dichlorobenzene induced hepatotoxicity in rats. Int. J. Pharm. Sci. Rev. Res. 2016 38 2 238 242
    [Google Scholar]
  126. Nguyen P.Q.T. Luu T.T. Bai Y. Nguyen G.K.T. Pervushin K. Tam J.P. Allotides: Proline-rich cystine knot α-amylase inhibitors from Allamanda cathartica. J. Nat. Prod. 2015 78 4 695 704 10.1021/np500866c 25832441
    [Google Scholar]
  127. Products A. Allamanda cathartica extracts and methods of use for activation of collagen synthesis for skin antiwrinkle effects. WO Patent 2014158792 A1 2014
    [Google Scholar]
/content/journals/ctmc/10.2174/0115680266392805251111080335
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A Comprehensive Review on Allamanda Genus: An Insight into the Traditional Uses, Phytochemistry, and Pharmacological Activities
Bentham Science Publishers ; https://doi.org/10.2174/0115680266392805251111080335
/content/journals/ctmc/10.2174/0115680266392805251111080335
/content/journals/ctmc/10.2174/0115680266392805251111080335
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  • Article Type:     Review Article
Keywords: Bioactivity ; Ethnopharmacology ; Allamanda ; Phytoconstituents ; Pharmacology ; Iridoids

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