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2000
Volume 25, Issue 28
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Chemistry research focuses on reducing energy and minimizing harmful byproducts. Pyrazoline and its derivatives have various pharmacological properties. This study aims to compile procedures for creating pyrazoline scaffolds from academic articles and online resources, such as Scopus, Google Scholar, Web of Science, Science Direct, Research Gate and libraries, aiming to minimize environmental and human health impacts. The primary objective is to determine the structural modifications and chemical groups that enhance their bioactivity, low toxicity, and handling. Furthermore, the review explores the bioavailability, synthetic challenges, and progress made in utilising pyrazoline derivatives in pharmaceutical and synthetic organic chemistry. The only goal is to provide insight into the creation of pyrazoline hybrid molecules that are very effective and less hazardous.

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References

  1. MallaR.R. SiragamS. DadiV. SeetiniB. Natural chalcones and their derivatives target the tumor microenvironment in colon cancer.Crit. Rev. Immunol.2022426273910.1615/CritRevImmunol.2023047427 37082949
     [Google Scholar]
  2. HuZ.J. YangJ.X. TianY.P. ZhouH.P. TaoX.T. XuG.B. YuW.T. YuX.Q. JiangM.H. Synthesis and optical properties of two 2,2′: 6′,2″-Terpyridyl-based two-photon initiators.J. Mol. Struct.20078391-3505710.1016/j.molstruc.2006.10.044
     [Google Scholar]
  3. KaurP. BerarU. RaghavN. Pyrazole and pyrazoline derivatives as anti-inflammatory agents.Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists.Bentham Science2024117143
     [Google Scholar]
  4. BellinaF. RossiR. RossiR. Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions.Tetrahedron200662317213725610.1016/j.tet.2006.05.024
     [Google Scholar]
  5. ParkS. KwonO.H. KimS. ParkS. ChoiM.G. ChaM. ParkS.Y. JangD.J. Imidazole-based excited-state intramolecular proton-transfer materials: synthesis and amplified spontaneous emission from a large single crystal.J. Am. Chem. Soc.200512728100701007410.1021/ja0508727 16011371
     [Google Scholar]
  6. EllerG.A. HolzerW. The 4-methoxybenzyl (PMB) function as a versatile protecting group in the synthesis of N-unsubstituted pyrazolones.Heterocycles2004632537255510.3987/COM‑04‑10190
     [Google Scholar]
  7. AkamaY. TongA. Spectroscopic studies of the keto and enol tautomers of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone.Microchem. J.1996531344110.1006/mchj.1996.0006
     [Google Scholar]
  8. ShiH.B. JiS.J. BianB. Studies on transition metal ions recognition properties of 1-(2-benzothiazole)-3-(2-thiophene)-2-pyrazoline derivatives.Dyes Pigments200773339439610.1016/j.dyepig.2005.12.011
     [Google Scholar]
  9. BaiG. LiJ. LiD. DongC. HanX. LinP. Synthesis and spectrum characteristic of four new organic fluorescent dyes of pyrazoline compounds.Dyes Pigments2007751939810.1016/j.dyepig.2006.04.017
     [Google Scholar]
  10. WeiX.Q. YangG. ChengJ.B. LuZ.Y. XieM.G. Synthesis of novel light-emitting calix[4]arene derivatives and their luminescent properties.Opt. Mater.200729893694010.1016/j.optmat.2006.02.005
     [Google Scholar]
  11. LiJ.F. GuanB. LiD.X. DongC. Study on the fluorescence properties of a new intramolecular charge transfer compound 1,5-diphenyl-3-(N-ethylcarbazole-3-yl)-2-pyrazoline.Spectrochim. Acta A Mol. Biomol. Spectrosc.200768240440810.1016/j.saa.2006.12.010 17379571
     [Google Scholar]
  12. LuZ. JiangQ. ZhuW. XieM. HouY. ChenX. WangZ. Novel pyrazoline derivative used as light emitter in blue organic electroluminescent devices.Synth. Met.2000111-11246546810.1016/S0379‑6779(99)00401‑4
     [Google Scholar]
  13. KnorrL. Note on the pyrazoline reaction.Ber. Dtsch. Chem. Ges.189326110010310.1002/cber.18930260123
     [Google Scholar]
  14. RaifordL.C. PetersonW.J. Identification of phenylhydrazones and isomeric pyrazolines obtained from chalcones.J. Org. Chem.19371654455110.1021/jo01235a003
     [Google Scholar]
  15. AzizG. NosseirM.H. DossN.L. RizkA.S. Synthesis of pyrazolines and corresponding isomers from fluoro-substituted chalcones.Indian J. Chem.197614B286291
     [Google Scholar]
  16. KabliR.A. KhalafA.A. ZimaityM.T. KhalilA.M. KaddahA.M. Al-RifaieH.A. Synthesis of a new series of furyl and thienyl substituted pyrazolines starting with furyl and thienyl chalcones.J. Indian Chem. Soc.19916814751
     [Google Scholar]
  17. JacobsT.L. ElderfieldR.C. Heterocyclic Compounds: Fivemembered heterocycles containing two hetero atoms and their benzo derivativesWileyNew York1957572
     [Google Scholar]
  18. DharD.N. Synthesis of hydroxy- and methoxychalcones and their derivatives.J. Indian Chem. Soc.196138823824
     [Google Scholar]
  19. BakerW. ButtV.S. Properties and orientation of some derivatives of 3-acylchromones.J. Chem. Soc.194821292142
     [Google Scholar]
  20. GheorghiuC.V. MateiV. Phototropy of ethylenic ketone semicarbazones and phenylhydrazones.Bull. Soc. Chim. Fr.19395613241334
     [Google Scholar]
  21. AubagnacJ.L. ElgueroJ. JacquirR. Structural characterization of paramagnetic octahedral homoscorpionate (polypyrazolylborate) cobalt complexes by 1H and 13C NMR spectroscopy and by FAB-mass spectrometry.Bull. Soc. Chim. Fr.196993292
     [Google Scholar]
  22. KatritzkyA.R. WangM. ZhangS. VoronkovM.V. SteelP.J. Regioselective synthesis of polysubstituted pyrazoles and isoxazoles.J. Org. Chem.200166206787679110.1021/jo0101407 11578235
     [Google Scholar]
  23. BorkhadeK.T. MarathevM.G. Syntheses of pyrazoles and pyrazolines.Indian J. Chem.19721014850
     [Google Scholar]
  24. SammourA.E.A. Behaviour of O- hydroxychalcones towards the action of phenylhydrazine, hydroxylamine, primary aliphatic amines and paraformaldehyde.Tetrahedron19642041067107110.1016/S0040‑4020(01)98444‑3
     [Google Scholar]
  25. SubbanwadG.R. VibhuteY.B. Studies on synthesis and antimicrobial activity of some new pyrazolines and N-phenylpyrazolines.J. Indian Chem. Soc.19926911781783
     [Google Scholar]
  26. DawaneB.S. Ph.D. Thesis Submitted to S. R.T. M.University, Nanded, India1998
     [Google Scholar]
  27. PaulS. GuptaR. Microwave assisted synthesis of 2-pyrazolines.Indian J. Chem.199837B12791282
     [Google Scholar]
  28. Raunak KumarV. MukherjeeS. Poonam PrasadA.K. OlsenC.E. SchäfferS.J.C. SharmaS.K. WattersonA.C. ErringtonW. ParmarV.S. Microwave mediated synthesis of spiro-(indoline-isoxazolidines): mechanistic study and biological activity evaluation.Tetrahedron200561235687569710.1016/j.tet.2005.03.027
     [Google Scholar]
  29. RaghuwanshiP.B. DoshiA.G. New pyrazolines from -2′-hydroxy -3′-nitro-5′-metyl-3-nitrochalcones.J. Indian Chem. Soc.199774421
     [Google Scholar]
  30. ShahM. PatelP. Synthesis of hydroxypyrazoline derivatives.Indian J. Chem.199635B12821286
     [Google Scholar]
  31. MorsiA.M.A. GamalA.G.K. Kinetics and mechanism of ligand-exchange reactions in fac-(piperidine)[1,2-bis(diphenylphosphino)ethane]tricarbonyltungsten(0).J. Indian Chem. Soc.1995721511
     [Google Scholar]
  32. FernandesY.J. ParekhH. Studies on pyrazolines. Part II. Preparation and antimicrobial activity of 3-(3-phenylsulfonamidophenyl)-5-arylpyrazolines.J. Indian Chem. Soc.1997743238
     [Google Scholar]
  33. SorathiaS.D. PatelV.B. ParikhA.R. Preparation and antimicrobial activity of 3-(p-(2′, 5′-dibromobenzenesulphonamido)-phenyl)~5-aryl-l HI acetyl/phenyl2-pyrazolines.Indian J. Chem.199736B630632
     [Google Scholar]
  34. HollaB.S. ShivanandaM.K. AkberaliP.M. A convenient synthesis of some fluorine-containing (arylfuryl)-N-phenylpyrazolines and their antibacterial activity.Ind. J. Het. Chem2001104305306
     [Google Scholar]
  35. DeshmukhM.S. RajputP.R. ChincholkarM.M. Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives.Asian J. Chem.199794848
     [Google Scholar]
  36. PalaskaE. ErolD. DemirdamarR. Synthesis and antidepressant activities of some 1,3,5-triphenyl-2-pyrazolines.Eur. J. Med. Chem.1996311434710.1016/S0223‑5234(96)80005‑5
     [Google Scholar]
  37. (a AnkhiwalaM.D. HathiM.V. Synthesis and antibacterial activity of some 1-phenyl-3,5-diaryl-2-pyrazolines and 3,5-diaryl-2-isoxazolines.J. Indian Chem. Soc.1994719587587
     [Google Scholar]
  38. (b AnkhiwalaM.D. NaikH.B. Preparation and antibacterial activity of 1-phenyl-3-(2”-hydroxy-3”-bromo-4”-n-butoxy-5”-nitrophen-1”-yl)-5-substituted-phenyl-2-pyrazolines and 3-(2”-hydroxy-3”-bromo-4”-n-butoxy-5”-nitrophen-l”-yl)-5-substituted-phenyl-2-isoxazolines.J. Indian Chem. Soc.1990673258260
     [Google Scholar]
  39. BharmalF.M. KaneriyaD.J. ParekhH.H. Synthesis of some pyrazoline derivatives as biologically active agents.Ind. J. Het. Chem200010189192
     [Google Scholar]
  40. SayedG.H. Synthesis of some new pyrazolines from 4-nitro- and 4-chloro-4′-methoxybenzalacetophenones. Part III.Indian J. Chem.198019B5364367
     [Google Scholar]
  41. KhalafA.A. KabliR.A. ZimaityM.T. KhalilA.M. KaddahA.M. Al-RifaieH.A. N-Derivatisation of some 3-(2-furyl)- and 3-(2-thienyl)-5-aryl-2-pyrazolines.Indian J. Chem.199332B11251129
     [Google Scholar]
  42. ShinghN. SangwanN.K. DhindraK.D. Complexes of derivatives of 4, 5‐Dihydro‐1H‐pyrazole as potential pesticides.J. Indian Chem. Soc.200178119122
     [Google Scholar]
  43. ShenoyG.G. BhatA.R. BhatG.V. KotianM. Synthesis and antimicrobial activities of 1, 3, 5 trisubstituted 2-pyrazolines.Ind. J. Het. Chem2001103197
     [Google Scholar]
  44. LevaiA. CziakyZ. JekoJ. SzeboZ. Synthesis of 3-acyl-4-aryl-2-pyrazolines by the reaction of α,β-unsaturated ketones with diazomethane.Indian J. Chem.1996351010911096
     [Google Scholar]
  45. SayedG.H. KjosenH. Chemistry of pyrazolines. Part V. Syntheses and mass spectrometric fragmentations of some 4-aryl-5-aroyl-2-pyrazolines.Indian J. Chem.198019B11980983
     [Google Scholar]
  46. ChouiterM.I. BoulebdH. PereiraD.M. ValentãoP. AndradeP.B. BelfaitahA. SilvaA.M.S. New chalcone-type compounds and 2-pyrazoline derivatives: Synthesis and caspase-dependent anticancer activity.Future Med. Chem.202012649350910.4155/fmc‑2019‑0342 32100558
     [Google Scholar]
  47. BhattA.H. ParekhH.H. ParikhK.A. ParikhA.R. Synthesis of pyrazolines and cyanopyridines as potential antimicrobial agents.Indian J. Chem.200140B5761
     [Google Scholar]
  48. RagaB. BodkeY. SangapureS.S. Synthesis of some 1H-pyrazolines bearing benzofuran as biologically active agents.Ind. J. Het. Chem20011113134
     [Google Scholar]
  49. Archana, Microwave assisted synthesis of some novel substituted 2-furyl pyrazoline derivatives.Indian J. Chem.200241B23712375
     [Google Scholar]
  50. KanjariyaH.M. Radhakri ShananT.V. RamchandranK.R. ParekhH. Studies on biological evaluation of cyanopyrans and pyrazolines using microwave assisted synthesis.Indian J. Chem.200443B14691573
     [Google Scholar]
  51. PawarS.B. DalviN.R. KaraleB.K. GillC.H. Synthesis of some 4-(2-hydroxy phenyl)-6-(1, 3-diphenyl-1H-pyrazol-4-yl) pyrimidine-2 (1H)-thiones and 2 (5-(1, 3-diphenyl-1H-pyrazol-4-yl)-1H-pyrazol-3-yl) phenols I nd.J. Het. Chem2005152197198
     [Google Scholar]
  52. LokhandeP.D. WagmareB.Y. SakateS.S. Regioselective one-pot synthesis of 3,5-diarylpyrazoles.Indian J. Chem.2005441123382342
     [Google Scholar]
  53. ShaharyarM. SiddiquiA.A. AliM.A. SriramD. YogeeswariP. Synthesis and in vitro antimycobacterial activity of N1-nicotinoyl-3-(4′-hydroxy-3′-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines.Bioorg. Med. Chem. Lett.200616153947394910.1016/j.bmcl.2006.05.024 16725324
     [Google Scholar]
  54. KolosN.N. PaponovB.V. OrlovV.D. LvovskayaM.I. DoroshenkoA.O. ShishkinO.V. Derivatives of Δ2-pyrazoline-products of 1,5-diaminotetrazole interaction with chalcone: Molecular structure and spectral properties.J. Mol. Struct.20067851-311412210.1016/j.molstruc.2005.10.004
     [Google Scholar]
  55. BudakotiA. AbidM. AzamA. Synthesis and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives and their Pd(II) complexes.Eur. J. Med. Chem.2006411637010.1016/j.ejmech.2005.06.013 16300860
     [Google Scholar]
  56. KudarV. Zsoldos-MádyV. SimonK. CsámpaiA. SohárP. Synthesis, IR-, NMR- and X-ray investigations on some novel N-hetaryl-dihydro-pyrazolyl ferrocenes. Study on ferrocenes, part 16.J. Organomet. Chem.2005690174018402610.1016/j.jorganchem.2005.05.045
     [Google Scholar]
  57. RautD.G. PatilS.B. KaduV.D. HublikarM.G. BhosaleR.B. Synthesis of asymmetric 1-thiocarbamoyl pyrazoles as potent anti colon cancer, antioxidant and anti-inflammatory agent.Anticancer. Agents Med. Chem.201918152117212310.2174/1871520618666181112122528 30417799
     [Google Scholar]
  58. RautD.G. LawandA.S. KaduV.D. HublikarM.G. PatilS.B. BhosaleD.G. BhosaleR.B. Synthesis of asymmetric thiazolyl pyrazolines as a potential antioxidant and anti-inflammatory agents.Polycycl. Aromat. Compd.2022421707910.1080/10406638.2020.1716028
     [Google Scholar]
  59. RangarajanT.M. MathewB. Recent updates an pyrazoline derivatives as promising candidates for neuropsychiatric and neurodegenerative disorder.Curr. Top. Med. Chem.202121302695271410.2174/1568026621999210902123132 34477522
     [Google Scholar]
  60. JainE.M. BhatnagarS. MuddagoniJ. SrivastavaR. PandaK.C. KulshresthaS. GuptaS.P. SinghG. Green synthesis of pyrazolines with potential antioxidant properties.Afr. J. Bio. Sc.202461495179532
     [Google Scholar]
  61. AqlanF.M. Synthesis characterization and in vitro antibacterial activity of the N -substituted bis-pyrazoline derivative as polycyclic aromatic compounds.Polycycl. Aromat. Compd.20224263412342110.1080/10406638.2020.1866040
     [Google Scholar]
  62. ZhangY.L. QinY.J. TangD.J. YangM.R. LiB.Y. WangY.T. CaiH.Y. WangB.Z. ZhuH.L. Synthesis and biological evaluation of 1-methyl-1Hindole–Pyrazoline hybrids as potential tubulin polymerization inhibitors.ChemMedChem201611131446145810.1002/cmdc.201600137 27159418
     [Google Scholar]
  63. JainS. PattnaikS. PathakK. KumarS. PathakD. JainS. VaidyaA. Anticancer potential of thiazole derivatives: A retrospective review.Mini Rev. Med. Chem.201818864065510.2174/1389557517666171123211321 29173166
     [Google Scholar]
  64. HavrylyukD. RomanO. LesykR. Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids.Eur. J. Med. Chem.201611314516610.1016/j.ejmech.2016.02.030 26922234
     [Google Scholar]
  65. SeverB. AltıntopM.D. GencerH.K. KapkacH.A. AtliO. BaysalM. OzdemirA. Synthesis of new thiazolyl-pyrazoline derivatives and evaluation of their antimicrobial, cytotoxic and genotoxic effects.Lett. Drug Des. Discov.201815774475610.2174/1570180814666170925152902
     [Google Scholar]
  66. SeverB. AltıntopM.D. RadwanM.O. ÖzdemirA. OtsukaM. FujitaM. CiftciH.I. Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.Eur. J. Med. Chem.201918211164810.1016/j.ejmech.2019.111648 31493743
     [Google Scholar]
  67. GomhaS.M. AbdelazizM.R. KhederN.A. Abdel-azizH.M. AlteraryS. MabkhotY.N. A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents.Chem. Cent. J.201711110510.1186/s13065‑017‑0335‑8 29086869
     [Google Scholar]
  68. MansourE. AboelnagaA. NassarE.M. ElewaS.I. A new series of thiazolyl pyrazoline derivatives linked to benzo[1,3]dioxole moiety: Synthesis and evaluation of antimicrobial and anti-proliferative activities.Synth. Commun.202050336837910.1080/00397911.2019.1695839
     [Google Scholar]
  69. LindenM. HofmannS. HermanA. EhlerN. BärR.M. WaldvogelS.R. Electrochemical synthesis of pyrazolines and pyrazoles via [3+2] dipolar cycloaddition.Angew. Chem. Int. Ed.2023629e20221482010.1002/anie.202214820 36478106
     [Google Scholar]
  70. Ozmen OzgunD. GulH.I. YamaliC. SakagamiH. GulcinI. SukurogluM. SupuranC.T. Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity.Bioorg. Chem.20198451151710.1016/j.bioorg.2018.12.028 30605787
     [Google Scholar]
  71. FarooqS. NgainiZ. One-pot and two-pot synthesis of chalcone-based mono and bis-pyrazolines.Tetrahedron Lett.202061415141610.1016/j.tetlet.2019.151416
     [Google Scholar]
  72. PeerzadeN.A. JadhavS.Y. BhosaleR.B. MasandV.H. GawaliR.G. Al-HussainS.A. Al-MutairiA.A. ZakiM.E.A. Pyrazole-based N-phenyl pyrazolines: Synthesis, docking, and pharmacological evaluation.Results Chem.20241110179310.1016/j.rechem.2024.101793
     [Google Scholar]
  73. YamaliC. GulH.I. KazazC. LeventS. GulcinI. Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes.Bioorg. Chem.20209610362710.1016/j.bioorg.2020.103627 32058104
     [Google Scholar]
  74. JamesJ.P. BhatK.I. MoreU.A. JoshiS.D. Design, synthesis, molecular modeling, and ADMET studies of some pyrazoline derivatives as shikimate kinase inhibitors.Med. Chem. Res.201827254655910.1007/s00044‑017‑2081‑9
     [Google Scholar]
  75. RavindarL. HasbullahS.A. RakeshK.P. HassanN.I. Pyrazole and pyrazoline derivatives as antimalarial agents: A key review.Eur. J. Pharm. Sci.202318310636510.1016/j.ejps.2022.106365 36563914
     [Google Scholar]
  76. LvP.C. LiD.D. LiQ.S. LuX. XiaoZ.P. ZhuH.L. Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents.Bioorg. Med. Chem. Lett.201121185374537710.1016/j.bmcl.2011.07.010 21802290
     [Google Scholar]
  77. KaplancikliZ.A. YurttaşL. Turan-ZitouniG. ÖzdemirA. ÖzicR. Ulusoylar-YıldırımŞ. Synthesis, antimicrobial activity and cytotoxicity of some new carbazole derivatives.J. Enzyme Inhib. Med. Chem.201227686887410.3109/14756366.2011.622273 21999633
     [Google Scholar]
  78. WangH.H. QiuK.M. CuiH.E. YangY.S. Yin-Luo XingM. QiuX.Y. BaiL.F. ZhuH.L. Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents.Bioorg. Med. Chem.201321244845510.1016/j.bmc.2012.11.020 23245802
     [Google Scholar]
  79. (a QiuK.M. WangH.H. WangL.M. LuoY. YangX.H. WangX.M. ZhuH.L. Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors.Bioorg. Med. Chem.20122062010201810.1016/j.bmc.2012.01.05122361272
     [Google Scholar]
  80. (b AwadallahF.M. PiazzaG.A. GaryB.D. KeetonA.B. CanzoneriJ.C. Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.Eur. J. Med. Chem.20137027327910.1016/j.ejmech.2013.10.003 24161704
     [Google Scholar]
  81. El-SayedM.A.A. Abdel-AzizN.I. Abdel-AzizA.A.M. El-AzabA.S. ElTahirK.E.H. Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.Bioorg. Med. Chem.201220103306331610.1016/j.bmc.2012.03.044 22516672
     [Google Scholar]
  82. HeJ. MaL. WeiZ. ZhuJ. PengF. ShaoM. LeiL. HeL. TangM. HeL. WuY. ChenL. Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.Bioorg. Med. Chem. Lett.201525112429243310.1016/j.bmcl.2015.03.087 25881822
     [Google Scholar]
  83. KumarP. ChandakN. KaushikP. SharmaC. KaushikD. AnejaK.R. SharmaP.K. Benzenesulfonamide bearing pyrazolylpyrazolines: Synthesis and evaluation as anti-inflammatory–antimicrobial agents.Med. Chem. Res.201423288289510.1007/s00044‑013‑0679‑0
     [Google Scholar]
  84. BandgarB.P. AdsulL.K. ChavanH.V. JaldeS.S. ShringareS.N. ShaikhR. MeshramR.J. GaccheR.N. MasandV. Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.Bioorg. Med. Chem. Lett.201222185839584410.1016/j.bmcl.2012.07.080 22901385
     [Google Scholar]
  85. PatelM.V. BellR. MajestS. HenryR. KolasaT. Synthesis of 4,5-diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors.J. Org. Chem.200469217058706510.1021/jo049264k 15471453
     [Google Scholar]
  86. SharmaP.K. KumarS. KumarP. KaushikP. KaushikD. DhingraY. AnejaK.R. Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory–antimicrobial agents.Eur. J. Med. Chem.20104562650265510.1016/j.ejmech.2010.01.059 20171763
     [Google Scholar]
  87. AmirM. KumarH. KhanS.A. Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.Bioorg. Med. Chem. Lett.200818391892210.1016/j.bmcl.2007.12.043 18182288
     [Google Scholar]
  88. a BarsoumF.F. HosniH.M. GirgisA.S. Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties.Bioorg. Med. Chem.200614113929393710.1016/j.bmc.2006.01.04216460945
     [Google Scholar]
  89. (b GhorabM.M. IsmailZ.H. Abdel-GawadS.M. AziemA.A. Antimicrobial activity of amino acid, imidazole, and sulfonamide derivatives of pyrazolo[3,4‐ d]pyrimidine.Heteroatom Chem.2004151576210.1002/hc.10212
     [Google Scholar]
  90. BekhitA.A. Abdel-AziemT. Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents.Bioorg. Med. Chem.20041281935194510.1016/j.bmc.2004.01.037 15051061
     [Google Scholar]
  91. AcharyaB.N. SaraswatD. TiwariM. ShrivastavaA.K. GhorpadeR. BapnaS. KaushikM.P. Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines.Eur. J. Med. Chem.201045243043810.1016/j.ejmech.2009.10.023 19926176
     [Google Scholar]
  92. JeongT.S. KimK.S. KimJ.R. ChoK.H. LeeS. LeeW.S. Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors.Bioorg. Med. Chem. Lett.200414112719272310.1016/j.bmcl.2004.03.072 15125921
     [Google Scholar]
  93. KarthikeyanM.S. HollaB.S. KumariN.S. Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines.Eur. J. Med. Chem.2007421303610.1016/j.ejmech.2006.07.011 17007964
     [Google Scholar]
  94. ShelkeS.N. MhaskeG.R. BonifácioV.D.B. GawandeM.B. Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives.Bioorg. Med. Chem. Lett.201222175727573010.1016/j.bmcl.2012.06.072 22832312
     [Google Scholar]
  95. Niyami SyedA. Kumar PrasadS.A. MarihalS.C. GurumurtyM. Heteroaryl cyclization and biological evaluation of some synthesized 9-(5-phenyl-1H-pyrazolin-3-yl)-9H-carbazoles.J. Adv. Pharm. Res.2012321419
     [Google Scholar]
  96. DesaiN.C. JoshiV.V. RajparaK.M. VaghaniH.V. SatodiyaH.M. Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity.J. Fluor. Chem.2012142677810.1016/j.jfluchem.2012.06.021
     [Google Scholar]
  97. RuhoğluO. OzdemirZ. CalişU. GümüşelB. BilginA.A. Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines.Arzneimittelforschung2005558431436 16149709
     [Google Scholar]
  98. GrosscurtA.C. Van HesR. WellingaK. 1-Phenylcarbamoyl-2-pyrazolines, a new class of insecticides. 3. Synthesis and insecticidal properties of 3,4-diphenyl-1-phenylcarbamoyl-2-pyrazolines.J. Agric. Food Chem.197927240640910.1021/jf60222a061
     [Google Scholar]
  99. PalaskaE. AytemirM. UzbayI.T. ErolD. Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines.Eur. J. Med. Chem.200136653954310.1016/S0223‑5234(01)01243‑0 11525844
     [Google Scholar]
  100. Rajendra PrasadY. Lakshmana RaoA. PrasoonaL. MuraliK. Ravi KumarP. Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines.Bioorg. Med. Chem. Lett.200515225030503410.1016/j.bmcl.2005.08.040 16168645
     [Google Scholar]
  101. MathewB. SureshJ. AnbazhaganS. MathewG. Pyrazoline: A promising scaffold for the inhibition of monoamine oxidase.Cent. Nerv. Syst. Agents Med. Chem.201413319520610.2174/1871524914666140129122632 24533911
     [Google Scholar]
  102. CanÖ.D. ÖzkayÜ.D. KaplancıklıZ.A. ÖztürkY. Effects of some 1,3,5-trisubstitued-2-pyrazoline derivatives on depression and anxiety parameters of mice.Arch. Pharm. Res.20093291293129910.1007/s12272‑009‑1915‑5 19784586
     [Google Scholar]
  103. AftabA. AsifH. ShahA.K. MohdM. BhandariA. Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives.J. Saudi Chem. Soc.2014205577584
     [Google Scholar]
  104. HavrylyukD. ZimenkovskyB. VasylenkoO. DayC.W. SmeeD.F. GrellierP. LesykR. Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones.Eur. J. Med. Chem.20136622823710.1016/j.ejmech.2013.05.044 23811085
     [Google Scholar]
  105. NairA.S. OhJ-M. KoyiparambathV.P. KumarS. SudevanS.T. SoremekunO. Development of halogenated pyrazolines as selective monoamine oxidase-B inhibitors: Deciphering via molecular dynamics approach.Molecules202126113264
     [Google Scholar]
  106. AhsanM.J. AliA. AliA. ThiriveedhiA. BakhtM.A. YusufM. Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders.ACS Omega202217743-,3820738245
     [Google Scholar]
  107. MukherjeeA. Recent Developments in the Biological Activities of 2- Pyrazoline Derivatives.Lincoln Publication202410111110.31674/book.2024ecc.009
     [Google Scholar]
  108. KumarG. TanwarO. KumarJ. AkhterM. SharmaS. PillaiC.R. AlamM.M. ZamaM.S. Pyrazole-pyrazoline as promising novel antimalarial agents: A mechanistic study.Eur. J. Med. Chem.201814914913914710.1016/j.ejmech.2018.01.082 29499486
     [Google Scholar]
  109. DeecherD.C. SoderlundD.M. RH 3421, an insecticidal dihydropyrazole, inhibits sodium channel-dependent sodium uptake in mouse brain preparations.Pestic. Biochem. Physiol.199139213013710.1016/0048‑3575(91)90133‑7
     [Google Scholar]
  110. WuJ. SongB.A. HuD.Y. YueM. YangS. Design, synthesis and insecticidal activities of novel pyrazole amides containing hydrazone substructures.Pest Manag. Sci.201268580181010.1002/ps.2329 22190278
     [Google Scholar]
/content/journals/ctmc/10.2174/0115680266374814250422053723
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Recent Synthetic Advancement and Medicinal Applications of Asymmetric Cyclic Pyrazoline-based Hydrazine Derivatives: A Review
Curr. Top. Med. Chem. 25, 3291 (2025); https://doi.org/10.2174/0115680266374814250422053723
/content/journals/ctmc/10.2174/0115680266374814250422053723
/content/journals/ctmc/10.2174/0115680266374814250422053723
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  • Article Type:     Review Article
Keyword(s): Asymmetric cyclic hydrazine; medicinal applications; pyrazoline-based hydrazine derivatives; syntheses methods

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