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image of Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of their DNA-Binding Properties and Inhibitory Activities on Ache and Buche

Abstract

Introduction

In this study, we report on the synthesis and characterization of new silicon (IV) phthalocyanine compounds (SiPcs) axially substituted with coumarin-linked derivatives, designed for potential application in photodynamic therapy (PDT) due to their photophysical properties.

Methods

Characterization was carried out using FT-IR, UV-Vis, MALDI-TOF-MS, and 1H NMR spectroscopy. In dimethyl sulfoxide (DMSO), the SiPcs produced singlet oxygen with quantum yields of 0.17 to 0.19, assessed by the DPBF quenching method. DNA binding studies UV-Vis spectroscopy and molecular docking suggested high binding affinities (ΔG0 values between -9.90 to -10.4 kcal/mol) and stable interactions with calf thymus DNA (ct-DNA).

Results

The compounds showed promising inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC values indicating higher potency and selectivity compared to galantamine, a known cholinesterase inhibitor.

Conclusion

The combined singlet oxygen generation, DNA binding, and enzyme inhibition data underscore the potential of these SiPc-coumarin derivatives as multifunctional agents for PDT and neuroprotective applications such as Alzheimer's disease (AD).

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2025-04-04
2025-09-13

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Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of their DNA-Binding Properties and Inhibitory Activities on Ache and Buche
Bentham Science Publishers ; https://doi.org/10.2174/0115680266368541250311084659
/content/journals/ctmc/10.2174/0115680266368541250311084659
/content/journals/ctmc/10.2174/0115680266368541250311084659
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  • Article Type:     Research Article
Keywords: DNA-binding ; singlet oxygen ; coumarin ; AChE ; Silicon(IV) phthalocyanines ; BuChE

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