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2000
Volume 25, Issue 28
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Introduction

In this study, we report on the synthesis and characterization of new silicon (IV) phthalocyanine compounds (SiPcs) axially substituted with coumarin-linked derivatives, designed for potential application in photodynamic therapy (PDT) due to their photophysical properties.

Methods

Characterization was carried out using FT-IR, UV-Vis, MALDI-TOF-MS, and 1H NMR spectroscopy. In dimethyl sulfoxide (DMSO), the SiPcs produced singlet oxygen with quantum yields of 0.17 to 0.19, assessed by the DPBF quenching method. DNA binding studies UV-Vis spectroscopy and molecular docking suggested high binding affinities (ΔG0 values between -9.90 to -10.4 kcal/mol) and stable interactions with calf thymus DNA (ct-DNA).

Results

The compounds showed promising inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC values indicating higher potency and selectivity compared to galantamine, a known cholinesterase inhibitor.

Conclusion

The combined singlet oxygen generation, DNA binding, and enzyme inhibition data underscore the potential of these SiPc-coumarin derivatives as multifunctional agents for PDT and neuroprotective applications such as Alzheimer's disease (AD).

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2026-02-28

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Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of their DNA-Binding Properties and Inhibitory Activities on Ache and Buche
Curr. Top. Med. Chem. 25, 3267 (2025); https://doi.org/10.2174/0115680266368541250311084659
/content/journals/ctmc/10.2174/0115680266368541250311084659
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  • Article Type:     Research Article
Keyword(s): AChE; BuChE; coumarin; DNA-binding; Silicon(IV) phthalocyanines; singlet oxygen

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