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2000
Volume 25, Issue 20
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Objective

This study systematically reviews the clinical applications, toxicological profile, and quality markers of Guchang Zhixie Pill, offering a reference for its rational clinical use, as well as its quality and safety assessment.

Methods

Relevant literature on the historical development, clinical applications, toxicology, and molecular characteristics of Guchang Zhixie Pill was retrieved from CNKI (https://www.cnki.net/), VIP (https://www.cqvip.com/), Sci-Hub (https://sci-hub.hkvisa.net/), TCMSP (https://old.tcmsp-e.com/tcmsp.php), Google Scholar (https://scholar.google.cz/schhp?hl=zh-CN), and PubMed (https://pubmed.ncbi.nlm.nih.gov/). Quality markers were predicted and analyzed based on established criteria to provide a scientific basis for ensuring clinical safety and efficacy.

Results

Formulated based on Wumei Pill, Guchang Zhixie Pill is widely used in the treatment of ulcerative colitis and irritable bowel syndrome. Quality marker prediction and analysis, conducted in accordance with the “five principles” of quality marker identification, indicated that ursolic acid, oleanolic acid, chlorogenic acid, neochlorogenic acid, citric acid, 5-hydroxymethylfurfural, coptisine, berberine hydrochloride, (+)-magnoflorine, 6-shogaol, 10-gingerol, dehydrocostus lactone, papaverine, noscapine, palmatine, and corydaline serve as potential Q-markers for this formulation.

Conclusion

As a classical prescription for intestinal astringency and antidiarrheal therapy, ensuring its rational clinical application is essential. The identification of 16 quality markers provides a scientific reference for quality control in future research.

© 2025 Bentham Science Publishers
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2025-12-16

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References

  1. ZhangZ.J. Treatise on Cold Damage Diseases.Beijing, ChinaPeople's Medical Publishing House2015
     [Google Scholar]
  2. LiuX.C. ChenS.L. XiaoX.H. ZhangT.J. HouW.B. LiaoM.L. A new concept on quality marker of Chinese materia medica: Quality control for Chinese medicinal products.Chin. Tradit. Herbal Drugs2016471443145710.7501/j.issn.0253‑2670.2016.09.001
     [Google Scholar]
  3. LiuC. ZhangH.Y. LiD. Reflection on clinical dosage of traditional Chinese medicine.Zhonghua Zhongyiyao Zazhi20203555085511
     [Google Scholar]
  4. SunS.M. Essential Prescriptions Worth a Thousand for Emergencies.Shanxi, ChinaShanxi Science and Technology Publishing House2020
     [Google Scholar]
  5. WangX. Medical Secrets of an Official.Beijing, ChinaChina Medical Science Press2011
     [Google Scholar]
  6. YanY.H. Yanshi Jisheng Fang.Beijing, ChinaChina Medical Science Press2012
     [Google Scholar]
  7. ChenY.Z. Treatise on the Three Categories of Pathogenic Factors and Prescriptions.Beijing, ChinaPeople's Medical Publishing House2007
     [Google Scholar]
  8. ChenS.W. Prescriptions from the Great Peace Imperial Grace Pharmacy.Beijing, ChinaChina Press of Traditional Chinese Medicine2020
     [Google Scholar]
  9. ZhuZ.H. Danxi’s Experiential Therapy.Beijing, ChinaPeople’s Military Medical Press2007
     [Google Scholar]
  10. XueJ. Neike Zhaiyao.Beijing, ChinaChina Medical Science Press2012
     [Google Scholar]
  11. WuK. Yifang Kao.Beijing, ChinaPeople's Medical Publishing House2018
     [Google Scholar]
  12. ZhaoX.K. Thorough Knowledge of Medicine.Beijing, ChinaPeople's Medical Publishing House2005
     [Google Scholar]
  13. YuT. Orthodox Transmission of Medicine.Shanxi, ChinaShanxi Science and Technology Publishing House2013
     [Google Scholar]
  14. YouY. Jinkui Yi.Beijing, ChinaChina Press of Traditional Chinese Medicine1999
     [Google Scholar]
  15. WangA. Collected Exegesis of Recipe.Beijing, ChinaChina Press of Traditional Chinese Medicine1997
     [Google Scholar]
  16. ChenF.Z. Compendium of Pediatrics.Beijing, ChinaPeople's Medical Publishing House2006
     [Google Scholar]
  17. ChenX.Y. Shifang Miaoyong.Fujian, ChinaFujian Science and Technology Publishing House2007
     [Google Scholar]
  18. WuQ. Golden Mirror of Medicine.Beijing, ChinaChina Press of Traditional Chinese Medicine1994
     [Google Scholar]
  19. WangA. Bencao Beiyao.Beijing, ChinaPeople's Medical Publishing House2017
     [Google Scholar]
  20. LiS.Z. Compendium of Materia Medica.Xian, ChinaXian Jiaotong University Press2015
     [Google Scholar]
  21. WangH.G. Tangye Bencao.Beijing, ChinaChina Press of Traditional Chinese Medicine2015
     [Google Scholar]
  22. LingH. Bencao Haili.China Press of Traditional Chinese Medicine1982
     [Google Scholar]
  23. ZhaoJ.C. Complete Record of Sacred Benevolence.Beijing, ChinaChina Press of Traditional Chinese Medicine2018
     [Google Scholar]
  24. ZhangZ.C. Bencao Chongyuan.Beijing, ChinaChina Press of Traditional Chinese Medicine1992
     [Google Scholar]
  25. WangA. Bencao Yidu.Taiyuan, ChinaShanxi Science and Technology Publishing House2015
     [Google Scholar]
  26. ZhuS. Puji Fang.Beijing, ChinaPeople's Medical Publishing House1982
     [Google Scholar]
  27. ChenZ.M. Compendium of Effective Prescriptions for Women.Beijing, ChinaChina Medical Science Press2019
     [Google Scholar]
  28. ShiW. Depei Bencao.Shanghai, ChinaShanghai Scientific & Technical Publishers2000
     [Google Scholar]
  29. WangH.Y. Peaceful Holy Benevolent Prescriptions.Beijing, ChinaPeople's Medical Publishing House2005
     [Google Scholar]
  30. QianY. Key to Therapeutics of Children’s Diseases.Nanning, ChinaGuangxi Science and Technology Press2015
     [Google Scholar]
  31. ShiK. Shizai Zhifang.Shanghai, ChinaShanghai Scientific & Technical Publishers2003
     [Google Scholar]
  32. HanH. Hanshi Yitong.Beijing, ChinaChina Press of Traditional Chinese Medicine1989
     [Google Scholar]
  33. ChenJ.M. Bencao Mengquan.Beijing, ChinaChina Press of Traditional Chinese Medicine2013
     [Google Scholar]
  34. HuangG.X. Bencao Qiuzhen.Taiyuan, ChinaShanxi Science and Technology Publishing House2015
     [Google Scholar]
  35. LanM. Diannan Bencao.Beijing, ChinaChina Press of Traditional Chinese Medicine2013
     [Google Scholar]
  36. GongT.X. Longevity and Life Preservation.Taiyuan, ChinaShanxi Science and Technology Publishing House2006
     [Google Scholar]
  37. WeiY.L. Shiyi Dexiao Fang.Shanghai, ChinaSecond Military Medical University Press2006
     [Google Scholar]
  38. NiJ.M. Bencao Huiyan.Shanghai, ChinaShanghai Scientific & Technical Publishers2005
     [Google Scholar]
  39. TangS.W. Zhenglei Bencao.Beijing, ChinaChina Medical Science Press2021
     [Google Scholar]
  40. ZhangJ.B. Complete Works of Jingyue.Beijing, ChinaChina Press of Traditional Chinese Medicine1994
     [Google Scholar]
  41. ZhuG.Y. Leizheng Huoren Shu.Tianjin, ChinaTianjin Science and Technology Press2003
     [Google Scholar]
  42. SuJ. Newly Revised Materia Medica.Beijing, ChinaChina Medical Science Press2019
     [Google Scholar]
  43. ChangM.Y. Rihuazi Bencao.Beijing, ChinaChina Medical Science Press2016
     [Google Scholar]
  44. LuD.X. Kaibao Bencao.Beijing, ChinaBeijing Science and Technology Press2019
     [Google Scholar]
  45. SuS. Bencao Tujing.Anhui, ChinaAnhui Science and Technology Press1994
     [Google Scholar]
  46. LiuW.T. Bencao Pinghui Jingyao.Beijing, ChinaChina Press of Traditional Chinese Medicine2013
     [Google Scholar]
  47. LuoT.Y. Weisheng Baojian.Beijing, ChinaChina Press of Traditional Chinese Medicine2013
     [Google Scholar]
  48. HongZ. Hongshi Yanji Fang.Shanghai, ChinaShanghai Scientific & Technical Publishers2003
     [Google Scholar]
  49. ShenK. Sushen Liangfang.Beijing, ChinaChina Medical Science Press2019
     [Google Scholar]
  50. YangS.Y. Renzhai Zhizhi Fanglun.Guizhou, ChinaGuizhou Science and Technology Press2016
     [Google Scholar]
  51. WangG. Boji Fang.Shanghai, ChinaShanghai Scientific & Technical Publishers2003
     [Google Scholar]
  52. YanY.H. Chongding Yanshi Jisheng Fang.Beijing, ChinaPeople's Medical Publishing House1980
     [Google Scholar]
  53. ZhangB.C. Bencao Biandu.Taiyuan, ChinaShanxi Science and Technology Publishing House2015
     [Google Scholar]
  54. ZhangL. TangR.S. SongJ. ZhangH.M. FuY.L. Textual Research on Principle of Dose Conversion in Ancient Famous Classical Formulas.Chin. J. Exp. Tradit. Med. Formula.2024301019620210.13422/j.cnki.syfjx.20240668
     [Google Scholar]
  55. LinY.Q. MuL.C. LiQ.W. TongX.L. Literature analysis on the measured weights of unmeasured unit drugs.Zhonghua Zhongyiyao Zazhi20183302740743
     [Google Scholar]
  56. JiaY. Guchang Zhixie pill for the treatment of chronic ulcerative colitis in 30 cases.J. Shaanxi Univ. Chin. Med.20083104363710.13424/j.cnki.jsctcm.2008.04.014
     [Google Scholar]
  57. ZhangW.W. MaiL.R. ZhangL. Effect of Gegen Qinlian Decoction Combined with Guchang Zhixie Pill on Ulcerative Colitis and lts Effect on Serum Levels of lL-1,IL-6 and TNF-α.Zhonghua Zhongyiyao Xuekan2021390921221510.13193/j.issn.1673‑7717.2021.09.053
     [Google Scholar]
  58. WangJ.Z. WangP. HouK.T. ZhangY.X. Effect of Guchang Zhixie Pill Combined with Kangfuxin Enema on Intestinal Flora and Inflammatory Factors in Patients with Ulcerative Colitis.World J. Integrated Tradit. and Western Med.202015122289229310.13935/j.cnki.sjzx.201229
     [Google Scholar]
  59. WuJ.H. ChenZ.K. Efficacy of Guchang Zhixie Pill and Sulfasalazine in Treatment of Paients withUlcerative Colitis and Influence of lL- 2 and lL- 8 in Serum, Liaoning.J. Tradit. Chin. Med.2014410346246410.13192/j.issn.1000‑1719.2014.03.031
     [Google Scholar]
  60. LeiR.X. WuG.R. Clinical observation of Guchang Zhixie pill combined with acupoint acupuncture in the treatment of diarrheal irritable bowel syndrome.Chin. J. Trauma and Disability Med.20132110203204 https://kns.cnki.net/kcms2/article/abstract?v=_NV5_o307Bxp3TTJOoY5T2zV8BdxquT8_SSqduBdMhdTVR4u5nv1ttNiipCSQ24u2BqQBEhovPEKgadn5AguhfEk5LATa98ioAo11cPtviLntk4sQWWnqaVTXtDybQdMlHx81yKHdeg=&uniplatform=NZKPT&language=CHS
    [Google Scholar]
  61. WuH. FanZ. YeM.Q. Clinical observation of Guchang Zhixie pill combined with Flupentixol and Melitracen Tablets in the treatment of diarrheal irritable bowel syndromeInner.Mongolia J. Tradit. Chin. Med.20163502868710.16040/j.cnki.cn15‑1101.2016.02.087
     [Google Scholar]
  62. WuM.Y. FangY. HuangX.G. ZhangZ. Observation on the curative effect of OctyloniuM BroMide combined with Guchang Zhixie pill in the treatment of diarrheal irritable bowel syndrome.Chin. Primary Health Care20112509868710.3969/j.issn.1001‑568X.2011.09.048
     [Google Scholar]
  63. GuoY. WeiX.J. WangY.X. Clinical effects of Guchang Zhixie Pill combined with mesalazine on mildlyactive Crohn’s disease.Zhongchengyao201941081844184710.3969/j.issn.1001‑1528.2019.08.018
     [Google Scholar]
  64. RenJ.T. Observation on curative effect of Jiedu Huayu Decoction combined with Guchang Zhixie pill on 84 patients with active ulcerative colitis.J. Qiqihar Medical Univ.201940131620162110.3969/j.issn.1002‑1256.2019.13.015
     [Google Scholar]
  65. YangY. Value of Guchang Zhixie pill combined with compound glutamine enteric-soluble capsules in the treatment of ulcerative colitis.J. North Pharm.201815033536
     [Google Scholar]
  66. WuG.H. GuoL.J. Clinical study on Guchang Zhixie Pills combined with sulfasalazine in treatment of ulcerative colitis.Drugs & Clinic.201830614101414
     [Google Scholar]
  67. SunG.Y. ChenB.L. Treatment of diarrhea-dominated irritable bowel syndrome with Piverium bromide combined with Guchang Zhixie Pill.Guangdong Yixue2003121365136610.13820/j.cnki.gdyx.2003.12.067
     [Google Scholar]
  68. YangH.Y. ZhangC. LeiL.P. Determination of Morphine in Guchang Zhixie Pills by HPLC.China Pharmaceuticals.201221184445
     [Google Scholar]
  69. LiX. ZhangM.T. GuoX.X. WangJ.D. LiD.H. MaX. Study on Change of Morphine Content in Yingsuqiao(Papaveris Pericarpium) Before and After Processing.Liaoning J. Trad. Chin. Med.2023501217417810.13192/j.issn.1000‑1719.2023.12.048
     [Google Scholar]
  70. YangH. YunL. WangH. Acute liver function injury caused by papaverine hydrochloride injection: a case report.China Pharm.2019220112512610.3969/j.issn.1008‑049X.2019.01.033
     [Google Scholar]
  71. MillerJ.A. CrossD.T. MoranC.J. DaceyR.G.Jr McFarlandJ.G. DiringerM.N. Severe thrombocytopenia following intraarterial papaverine administration for the treatment of vasospasm.J. Neurosurg.199583343543710.3171/jns.1995.83.3.0435 7666219
     [Google Scholar]
  72. KahramanerZ. ErdemirA. TürkoğluE. CoşarH. SütçüoğluS. ÖzerE.A. Papaverine intoxication in a newborn: an unusual case report.Turk. J. Pediatr.2014565532534 26022590
     [Google Scholar]
  73. AnJ.J. First aid and nursing care of anaphylactic shock caused by papaverine.Chin. J. Convalescent Med.2018270222322410.13517/j.cnki.ccm.2018.02.048
     [Google Scholar]
  74. GaoX.Y. XiaY.M. Rare adverse reactions of papaverine.Chin. Community Doctors20060259
     [Google Scholar]
  75. WangL.P. Literature Review of Adverse Drug Reactions Induced by Papaverine.Chinese Journal of Drug Abuse Prevention and Treatment.2020260423323610.15900/j.cnki.zylf1995.2020.04.014
     [Google Scholar]
  76. YangL.L. XingJ.P. ZhangZ.Y. WangX. TanJ.Y. WangX. ChengS.Q. WenJ. XuX.F. LiX.R. Effects of Purification on Quality of Fructus Mume and the Quality Standard Research of Pulp of Fructus Mume.World Chin. Med.2024190116+13 https://xueshu.baidu.com/usercenter/paper/show?paperid=160j0t80102704n019120g90e6235581&site=xueshu_se&hitarticle=1.
     [Google Scholar]
  77. ZhangY. QuQ. LeiX. ZhaoX. ZhangX. WeiX. TangY. DuanX. SongX. Quality markers of Guchang Zhixie pills based on multicomponent qualitative and quantitative analysis combined with network pharmacology and chemometric analysis.J. Pharm. Biomed. Anal.202424011593410.1016/j.jpba.2023.115934 38157739
     [Google Scholar]
  78. YangY.T. WangR. QianC.C. WuR. OuJ.M. Research progress of chemical compositions, pharmaological action and quality markers prediction of Mume fructus.Zhongchengyao202345051583158810.3969/j.issn.1001‑1528.2023.05.032
     [Google Scholar]
  79. FuL. FuQ. LiJ. TongX. Research progress on chemical constituents and pharmacological effects of Coptidis rhizoma.Acta Chin. Med. Pharmacol.20214902879210.19664/j.cnki.1002‑2392.210044
     [Google Scholar]
  80. XuT. CongZ.F. HeM.Y. DongP. DaiL. GaoP. Research Progress and Quality Marker Analysis ofZingiberis Rhizoma, Shandong J.Trad. Chin. Med.2022410556957510.16295/j.cnki.0257‑358x.2022.05.021
     [Google Scholar]
  81. ZhengJ.M. ShangM.Y. WangJ.L. DaiG.N. SongJ.Y. DaiB.Z. Research progress on chemical constituents, pharmacological effects and clinicaapplications of Aucklandiae Radix and prediction analysis on Q-Marker.Chin. Tradit. Herbal Drugs202153224198421310.7501/j.issn.0253‑2670.2022.13.033
     [Google Scholar]
  82. ZhangX.P. ShiX.F. ZhangH.Y. ZhuR.Y. ZhangC.X. Establishment of HPLC Fingerprint and Content Determination of 5 Components inPapaveris Pericarpium.China Pharm.202132222755276010.6039/j.issn.1001‑0408.2021.22.12
     [Google Scholar]
  83. FengJ. ChenK. ShenS. LuoY. LiuX. ChenX. GaoW. TongY. The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo.Biomed. Pharmacother.202316711551111551110.1016/j.biopha.2023.115511 37729733
     [Google Scholar]
  84. KimC.K. YuJ. LeeM. Molecular Networking-Guided Isolation of a Phenolic Constituent from Prunus mume Seed and Its Antioxidant and Anti-Inflammatory Activities.Foods20231261146114610.3390/foods12061146 36981073
     [Google Scholar]
  85. ZhangJ.C. LiangH. WangY. XiW. LiZ.G. Research Progress of Pharmacological Action of Wumei(Mume Fructus).Liaoning Zhongyiyao Daxue Xuebao2021230812212610.13194/j.issn.1673‑842x.2021.08.025
     [Google Scholar]
  86. SalamaS.A. AL-FaifiZ.E. MasoodM.F. El-AmierY.A. Investigation and Biological Assessment of Rumex vesicarius L. Extract: Characterization of the Chemical Components and Antioxidant, Antimicrobial, Cytotoxic, and Anti-Dengue Vector Activity.Molecules20222710317710.3390/molecules27103177 35630653
     [Google Scholar]
  87. LiuY. RenB.J. ZouX.Y. LuJ.Y. WangL. GanD.H. Research progress of pharmacological action and effective drug carrier of Berberine.J Hainan Med Uni2020261713481352+135710.13210/j.cnki.jhmu.20200408.006
     [Google Scholar]
  88. Alipour NoghabiS. Ghamari kargarP. BagherzadeG. BeyzaeiH. Comparative study of antioxidant and antimicrobial activity of berberine-derived Schiff bases, nitro-berberine and amino-berberine.Heliyon2023912e2278310.1016/j.heliyon.2023.e22783
     [Google Scholar]
  89. XuZ. ZhangX. WangW. ZhangD. MaY. ZhangD. ChenM. Fructus mume (Wu Mei) attenuates acetic acid-induced ulcerative colitis by regulating inflammatory cytokine, reactive oxygen species, and neuropeptide levels in model rats.J. Med. Food202225438940110.1089/jmf.2021.K.0155 35438553
     [Google Scholar]
  90. XiangJ. LiuX. ZhongS. FangZ. ShenS. TangJ. LaiS. LaiK. Fructus mume protects against cigarette smoke induced chronic cough Guinea pig.J. Med. Food202023219119710.1089/jmf.2019.4423 32017647
     [Google Scholar]
  91. FanA.Q. HouB.L. ZhuJ. Metabolomics-based study on the mechanism of treatment of ulcerative colitis by the traditional Chinese medicine Guchang Zhixie Wan in mice.Zhongguo Xin Yao Zazhi202433111144115410.3969/j.issn.1003‑3734.2024.11.013
     [Google Scholar]
  92. LiuX.W. SunY.T. Research progress on clinical and pharmacological effects of Papaverine.Zhongguo Yaowu Yu Linchuang200660969769910.3969/j.issn.1671‑2560.2006.09.019
     [Google Scholar]
  93. WangY. FanX.X. YangJ. WangZ.Q. WangN. ChenJ.Q. LiuC.X. MaX.J. GaoX.L. TuP.F. ChaiX.Y. [Research progress on terpenes and pharmacological effects of Saussurea lappa].Zhongguo Zhongyao Zazhi202045245917592810.19540/j.cnki.cjcmm.20200903.601 33496131
     [Google Scholar]
  94. QuY. FuC.M. HuH.L. ZhangJ.M. XuL.J. Effects of Radix vladimiriae and paper-roast products on gastric empty andintestinal propulsive function of mice.Huaxi Yaoxue Zazhi2010250326927110.13375/j.cnki.wcjps.2010.03.006
     [Google Scholar]
  95. HeK. HuY. MaH. ZouZ. XiaoY. YangY. FengM. LiX. YeX. Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.Biochim. Biophys. Acta Mol. Basis Dis.2016186291696170910.1016/j.bbadis.2016.06.006 27287254
     [Google Scholar]
  96. ZhangX. ZhaoY. XuJ. XueZ. ZhangM. PangX. ZhangX. ZhaoL. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats.Sci. Rep.2015511440510.1038/srep14405 26396057
     [Google Scholar]
  97. YuL.Y. LiX. CaiP.J. QiangM.Q. DongB.H. JiangY.X. HuangQ.W. ChenZ.M. Effects of Zingiber officinale and processed Zingiber officinale on pharmacodynamic indexes and intestinal flora on gastric ulcer rats with spleen-stomach deficiency and cold type.China Pharm.202233202460246510.6039/j.issn.1001‑0408.2022.20.06
     [Google Scholar]
  98. FuM. Study on Chemical Constituents of Coptis Chinensis and Dried Ginger Herb Combination and its Anti-gastric Cancer Effect, Hubei Univ.Chin. Med.202310.27134/d.cnki.ghbzc.2022.000102
     [Google Scholar]
  99. LiW. HuaB. SaudS.M. LinH. HouW. MatterM.S. JiaL. ColburnN.H. YoungM.R. Berberine regulates AMP‐activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice.Mol. Carcinog.201554101096110910.1002/mc.22179 24838344
     [Google Scholar]
  100. AchiwaY. HasegawaK. UdagawaY. Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells.Biosci. Biotechnol. Biochem.2007711313710.1271/bbb.60288 17213663
     [Google Scholar]
  101. LeiP. LiZ. HuaQ. SongP. GaoL. ZhouL. CaiQ. Ursolic acid alleviates neuroinflammation after intracerebral hemorrhage by mediating microglial pyroptosis via the NF-κB/NLRP3/GSDMD Pathway.Int. J. Mol. Sci.202324191477110.3390/ijms241914771 37834220
     [Google Scholar]
  102. ZhangS.X. LiJ.L. FengW.J. Effects of berberine and Wnt/β-catenin signaling pathway inhibitors onproliferation, apoptosis and glucose metabolism of gastric cancer cell line MKN45.J. Basic Clin. Med.20202607893897
     [Google Scholar]
  103. LiuS. WangJ.W. Anti-colorectal Cancer Mechanism of Zuojinwan and lts Main Monomer Components: A Review.Zhongguo Shiyan Fangjixue Zazhi2023292220421410.13422/j.cnki.syfjx.20232225
     [Google Scholar]
  104. HuangH. KimM.O. KimK.R. Anticancer effects of 6-shogaol via the AKT signaling pathway in oral squamous cell carcinoma.J. Appl. Oral Sci.2021
     [Google Scholar]
  105. QiL.W. ZhangZ. ZhangC.F. AndersonS. LiuQ. YuanC.S. WangC.Z. Anti-colon cancer effects of 6-shogaol through G2/M cell cycle arrest by p53/p21-cdc2/cdc25A crosstalk.Am. J. Chin. Med.201543474375610.1142/S0192415X15500469 26119958
     [Google Scholar]
  106. XuL. LuX. LiT. DaiR.Z. JiangY. Effects of dehydrocostus lactone on proliferation, metastasis and invasion of laryngeal carcinoma cells via PI3K/Akt pathway.J. Med. Res.2023520910811210.11969/j.issn.1673‑548X.2023.09.022
     [Google Scholar]
  107. ShaoY.P. LiuB. LiW.M. ShaoX.L. ChenQ.G. Dehydrocostus lactone induces autophagy, apoptosis, and oxidative stress in gastric cancer cells.Chin. J. Comp. Med.20213112273410.3969/j.issn.1671‑7856.2021.12.005
     [Google Scholar]
  108. MiaoJ.W. ChenJ. DengX.S. XiongS. LiG.L. MaQ. Dehydrocostuslactone inhibits proliferation and promotes apoptosis of human hepatocellular carcinoma cell line HepG2.Basic Clin. Med.202040101369137310.16352/j.issn.1001‑6325.2020.10.011
     [Google Scholar]
  109. LuQ. TangY. LuoS. GongQ. LiC. Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases.Am. J. Chin. Med.20235182121215610.1142/S0192415X2350091X 37930333
     [Google Scholar]
  110. KongW. WeiJ. AbidiP. LinM. InabaS. LiC. WangY. WangZ. SiS. PanH. WangS. WuJ. WangY. LiZ. LiuJ. JiangJ.D. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.Nat. Med.200410121344135110.1038/nm1135 15531889
     [Google Scholar]
  111. YnagX.Y. HuangM.Y. ShiZ.Y. YanD. Study on hypoglycemic mechanism of berberine through glucose transporterexpression in intestinall cells.Zhonghua Zhongyiyao Zazhi2021360419261930
     [Google Scholar]
  112. YuH. TangH. HuG. ChenZ. GuoM. JiangB. ZhangE. HuC. Comparative study on main compounds and hypoglycemic effects of dispensing granules of Coptidis Rhizoma and Scutellaria–Coptis herb couple with traditional decoction.Chin. Med.202318114114110.1186/s13020‑023‑00848‑z 37907988
     [Google Scholar]
  113. ChenZ.X. WangC.X. XuL.Q. LiuY.Y. Effect of Berberine on gastrointestinal hormones and glucose and lipid metabolismin patients with early type 2 diabetes mellitus.China Mod. Med.20212834120122+126 https://kns.cnki.net/kcms2/article/abstract?v=FY8FZShUIjFSQn7PP1BLxNQfHB34l9BPa95JnoBqskm5dcHy0D7J5zLsnTJoTVPjQdHXZGTTeEXqOgxuGt7T-MxwduFkf2jSfKFJPagEMVqyL5Z1_eBBlyZpAC1LN8IKKko_7vkpSkocxW4KPWPVHg==&uniplatform=NZKPT&language=CHS
    [Google Scholar]
  114. WangL. ZhangH.Y. WangL. [Comparison of pharmacological effects of Fructus Mume and its processed products].Zhong Yao Cai201033335335610.13863/j.issn1001‑4454.2010.03.01 20681297
     [Google Scholar]
  115. XuL. FanQ.L. Advances in the molecular mechanisms of ursolic acid and its isomer oleanolic acic on treatment of type 2 diabetes and assciated complications.Chin. J. New Clinical Med.2019120770270710.3969/j.issn.1674‑3806.2019.07.02
     [Google Scholar]
  116. XiaoW.P. YangF.F. WuH.Z. XiongY.Y. Predicting the Mechanism of the Analgesic Property of Yanhusuo Based on Network Pharmacology.Nat. Prod. Commun.2019141010.1177/1934578X19883071
     [Google Scholar]
  117. WangL. ZhangY. WangZ. GongN. KweonT.D. VoB. WangC. ZhangX. ChungJ.Y. AlachkarA. LiangX. LuoD.Z. CivelliO. The antinociceptive properties of the Corydalis yanhusu extract.PLoS One2016119e016287510.1371/journal.pone.0162875 27622550
     [Google Scholar]
  118. WangZ.C. JiangM.R. YueZ.Z. ZhangJ.Q. ChenM.Y. WangH.N. WeiX.T. WangM.L. ShiS.H. WangY.Z. Safety and analgesic effect of total alkaloids of Corydalis yanhusuo patch on neuropathic pain rats.Mod. J. Integrated Trad. Chin. and Western Med.2023320333634110.3969/j.issn.1008‑8849.2023.03.008
     [Google Scholar]
  119. GuoJ. DingN. ChenX.X. Therapeutic Effect of Papaverine Hydrochloride in Acute Calculus-caused Renal Colic Unresponsive to Conventional Treatment.Chin. Gen. Pract.201114182043204510.3969/j.issn.1007‑9572.2011.18.017
     [Google Scholar]
  120. YangK. LiZ.Z. PanL. ZhangJ. WeiW.S. ZhaoQ.M. XuZ.Y. GaoB.R. Protective effects of total fumaric alkaloids on myocardium of rats with isoproterenol-induced myocardial infarction.Chin. J. Clin. Res201629081057106110.13429/j.cnki.cjcr.2016.08.013
     [Google Scholar]
  121. GaoZ.X. WangX.Q. ZhouG.S. WangT.S. YuB. YanH. Research Progress on Processing Methods, Chemical Constituents, Pharmacologica Action, and Prediction Analysis of Quality Markers of Black Ginger.J. Nanjing Univ. Tradit. Chin. Med.2023390992794210.14148/j.issn.1672‑0482.2023.0927
     [Google Scholar]
  122. TangY. SuH. NieK. WangH. GaoY. ChenS. LuF. DongH. Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway.Biomed. Pharmacother.202417011601210.1016/j.biopha.2023.116012 38113631
     [Google Scholar]
  123. ZengL.Y. ZengH.L. TanS.Y. YanG.Y. HuangT.Y. ZhangL.W. GuoJ.M. MaoL.N. Overview of Study on Production Mechanism, Metabolism, Biological Activity of 5-HMF and Its Changes in Chinese Medicine Processing.J. Basic Clin. Med.2023290350751410.19945/j.cnki.issn.1006‑3250.2023.03.022
     [Google Scholar]
  124. YanS.G. HuiY. LiQ. LiJ.T. WeiH.L. Effect of Coptidis Rhizoma-Zingiberis Rhizoma Extract on Colonic Epithelium TLR4/NF-kB Signaling Pathway in Mice with Ulcerative Colitis.Zhongguo Shiyan Fangjixue Zazhi20202604707510.13422/j.cnki.syfjx.20200202
     [Google Scholar]
  125. ZhangW.J. NingH.C. ZhouY. LiuL. ZhaoY. Effect of Compatibility of Coptidis and Ginger on Pharmacokinetics of Five Alkaloids ofcoptidis in Rats.Acta Chin. Med.Pharmacol20154304151910.19664/j.cnki.1002‑2392.2015.04.006
     [Google Scholar]
  126. HuangW.J. LiuJ. ChenL. Effects of different proportions compatibility of Coptis chinensis Franch. and Zingiber officinale Roscoe on the content of effective components.Xinjiang Yike Daxue Xuebao201841101298130110.3969/j.issn.1009‑5551.2018.10.025
     [Google Scholar]
  127. YuC.L. LuY.J. WuQ.F. Optimization of anti-influenza effect compatibility ratio of Huanglian (CoptidisRhizoma)-Ganjiang (Zingiberis Rhizoma) via response surface method.Chin, Archives Tradit. Chin. Med.20203849810010.13193/j.issn.1673‑7717.2020.04.023
     [Google Scholar]
  128. WenJ.X. LiY. HaoJ.J. Study on the Mechanism of Coptidis Rhizoma-Aucklandiae Radix on the Treatment of Ulcerative Colitis Based on Network Pharmacology.J. Dali Univ.2019410323910.3969/j.issn.2096‑2266.2019.10.008
     [Google Scholar]
  129. WanL.L. ZhangZ.Q. WangY.Z. ChenY.Q. Optimum selection of the compatibility ratio of Coptidis Rhizoma and Aucklandiae Radix in Xianglian pills.Zhong Yao Cai200831121898190010.13863/j.issn1001‑4454.2008.12.044
     [Google Scholar]
  130. WanL.L. ZhangZ.Q. LiuW.J. LiuZ.H. Pharmacokinetic Study on Berberine in the Extractof Rhizoma Coptidis-RadixAucklandiae Drug-pair in Rats.Chin. J. Mod. Appl. Pharm.2009260644344610.13748/j.cnki.issn1007‑7693.2009.06.005
     [Google Scholar]
  131. YangY.T. QianC.C. WuR. WangR. OuH.M. LiuS.J. Exploring the mechanism of the Fructus Mume and Rhizoma Coptidis herb pair intervention in Ulcerative Colitis from the perspective of inflammation and immunity based on systemic pharmacology.BMC Complement. Med. Ther.20232311110.1186/s12906‑022‑03823‑7
     [Google Scholar]
  132. ShiY.H. FanH.S. LiuX. XiaoP. ShenW.X.H.B. Chen HB and D.D. Sun. The Study of Compatibility Mechanism of Coptidis Rhizoma-Mume Fructus in Xiaoai Jiedu Prescription from Perspective of Chemical Components and Intestinal Microflora.J. Nanjing Univ. Tradit. Chin. Med.2019350219920410.14148/j.issn.1672‑0482.2019.0199
     [Google Scholar]
  133. JiangX. LiS.S. ZhangB. LiuL. WengL.D. LiuQ. Studies on Fingerprint of Coptis -Prunus Mum Couplet Medicines of Different Proportions.Liaoning Zhongyiyao Daxue Xuebao2012141019519710.13194/j.jlunivtcm.2012.10.197.jiangx.052
     [Google Scholar]
  134. ChenH. ZhouJ. XuH.L. ZhouL. Effect and Mechanism of COPTIDIS RHIZOMA and MUME FRUCTUS Extracts on LPS-Induced Inflammation in Mice.Pharmacol. Clin. Chin. Mater. Med.20233905465110.13412/j.cnki.zyyl.20230420.007
     [Google Scholar]
  135. Pharmacopoeia of the People’s Republic of China 2020 Edition.,2020 https://db2.ouryao.com/yd2020/index.php?cid=1
    [Google Scholar]
  136. ChenY. GaoC.X. YeC.S. ZhangY.J. JiangX.Y. QuanS.J. The chemical constituents of Wumei pills were identified by UHPLC-Q-Orbitrap HRMS.Zhong Yao Cai202245092151215610.13863/j.issn1001‑4454.2022.09.022
     [Google Scholar]
  137. TangW.R. TianM.G. TangL. DuH. FanG. PanZ. Study on 1H-NMR Fingerprints of Prunus mume.China Pharm201829192644264710.6039/j.issn.1001‑0408.2018.19.12
     [Google Scholar]
  138. WangX.H. LiuL. WangJ. JinY. Study on quality standard of Guchang Zhixie pills.Shaanxi J. Tradit. Chin. Med201435091244124710.3969/j.issn.1000‑7369.2014.09.079
     [Google Scholar]
  139. LiuY.R. SongZ.X. ZhangY.L. YeN. CaiM.M. WangX.H. TangZ.S. LiuL. SQFM Methods Based on HPLC-DAD with Five Wavelengths for Fingerprint Determination of Guchang Zhixie Pill and Powders.Zhongguo Shiyan Fangjixue Zazhi20152115657010.13422/j.cnki.syfjx.2015150065
     [Google Scholar]
  140. WangM. ShiY.J. LiuL. WangX.H. NianJ.J. WuJ.H. Study on mixing uniformity of Guchang Zhixie Pills by near infrared spectroscopy.Shaanxi J. Tradit. Chin. Med.2016370110911010.3969/j.issn.1000‑7369.2016.01.056
     [Google Scholar]
  141. LiuY.L. YuanH. LiD.M. FengL. The contents of three alkaloids in Papaveris Pericarpium were determined by UPLC method.Zhong Yao Cai201134091386138810.13863/j.issn1001‑4454.2011.09.028
     [Google Scholar]
  142. LiD. LiJ.T. ZengY. ZhangH.C. XiaoH. WangJ.Y. Study on the content of effective components in different grades of Papaveris Pericarpium.Zhongguo Zhongyao Zazhi2010351722462249 21137333
     [Google Scholar]
  143. JiS. WangK. Determination of morphine, codeine and papaverine in poppy husk by GC.Chin. Tradit. Herbal Drugs19988526528
     [Google Scholar]
  144. WangW.F. WeiW.G. Determination of morphine and berberine hydrochloride in Guchang Zhixie Pills by HPLC.Chin. Trad. Patent Med.20103206967970
     [Google Scholar]
  145. OkaP. ParrH. BarberioB. BlackC.J. SavarinoE.V. FordA.C. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis.Lancet Gastroenterol. Hepatol.202051090891710.1016/S2468‑1253(20)30217‑X
     [Google Scholar]
/content/journals/ctmc/10.2174/0115680266328765250217050926
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Guchang Zhixie Pill: A Comprehensive Review of the Clinical Applications, Toxicological Profile, and Quality Markers
Curr. Top. Med. Chem. 25, 2399 (2025); https://doi.org/10.2174/0115680266328765250217050926
/content/journals/ctmc/10.2174/0115680266328765250217050926
/content/journals/ctmc/10.2174/0115680266328765250217050926
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  • Article Type:     Review Article
Keyword(s): clinical applications; Guchang Zhixie Pill; historical development; quality markers; toxicology

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