Human Topopoisons From Weeds : A Review

Background: The clinical efficacy of the current anticancer agents that are being in use was reduced due to reappearance of carcinoma and severe adverse effects of chemotherapy agents. Hence there is a need to discover novel anticancer molecules which is possible from nature only. The dual topo drugging is an important phenonomena in the cancer treatment. Even though many synthetic drugs as topo- poisons have been developed and used in the clinical trials, but having many challenges and are not successful due to cancer resistance. Objective: Hence there is a current demand for new human dual topo-poisons I & II, which is possible from unexplored plants and algal sources. Conclusion: Hence the current review is focused on the importance of latest discovered topopoison leads like (Tetrahydro-2-(hydroxymethyl)-6-(octadecahydro-2,7,10atrimethyl- 1-propylchrysen-8-yloxy)-2HPyran- 3,4,5-triol, (1E)-1-hydroxyprop-1-en-2-yl (2E)-3-(4- hydroxy-3-methoxyphenyl)prop-2-enoate, Ruscogenin etc., from the unexplored weeds of the Niligiris like Solanum mauritianum, Cytisus scoparius etc. and also the novel lipids like Sulpha quinovosyl dicyl glycerol and methyl gamma linolenate discovered recently from the algae like Arthrospira Platensis using current high throughput screening technologies like flash chromatography and in-silico molecular tools.