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Volume 12, Issue 1
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846
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Abstract

Background

Acne vulgaris is a prevalent dermatological condition characterized by the inflammation of sebaceous follicles. This inflammation results in various clinical manifestations, including open and closed comedones, papules, pustules, nodules, and cysts, which predominantly appear on the face. The impact of acne vulgaris extends beyond physical symptoms, often affecting psychological well-being and quality of life, particularly among adolescents. Given this condition's widespread prevalence and significant implications, there is a pressing need for effective and accessible treatments.

Objective

This study aimed to evaluate the impact of Kencur Rhizome Ethanol Extract Gel (Kaempferia galanga L. Rhizoma / KGR) on mild and moderate acne vulgaris lesions among high school students.

Method

Twenty-four high school students were divided into three groups: Group 1 received 0.75% Kaempferia galanga rhizome ethanol extract gel, Group 2 received a combination gel of 0.75% Kaempferia galanga ethanol extract, and 75% benzoyl peroxide with 1% clindamycin gel, and Group 3 received 1% clindamycin gel. The number of subjects in each group was determined using the G Power application. The distribution of gels was randomly assigned using the “Randomly Assign Subjects to Treatment Group” application. Before treatment, blood samples were taken to measure IL-8 levels. After three weeks of treatment, bilateral facial photographs were taken: one with the right side tilted at 45 degrees and the other with the left side tilted at 45 degrees. Blood samples were collected again for IL-8 measurement, and high-resolution photographs of both sides of the face were taken to analyze acne lesions using the ImageJ application.

Result

A combination of 0.75% KGR ethanol extract gel and 1% clindamycin gel significantly reduced the severity of AV lesions by affecting IL8 expression (p=0.042) in reducing the severity of mild and moderate AV lesions. For AV lesions using the ImageJ application, the administration of group 2 gel (a combination of 0.75% KGR ethanol extract gel and 1% clindamycin gel) has a significant effect on reducing the severity of mild and moderate degrees of whitehead or blackhead (p = 0.030) and nodules (p = 0.035) in acne vulgaris.

Conclusion

A combination of 0.75% kencur rhizome ethanol extract gel and 1% clindamycin gel effectively alleviate acne vulgaris symptoms while also reducing inflammation of acne vulgaris lesions.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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References

  1. TriatmakusumaY. Serum interleukin-6 levels are positively correlated with the severity of acne vulgaris.J La Medihealtico.20245158166
     [Google Scholar]
  2. SundarP.K. Impact of acne vulgaris on the psychiatric morbidity & quality of life of patients- a cross sectional study.J Evid Based Med Healthc.201923
     [Google Scholar]
  3. AfrenI KurniawatiY DibaS AryaniIA ArgentinaF Impact of particulate matter 2.5 in acne vulgaris: A literature review.Jurnal RSMH Palembang201451340349
     [Google Scholar]
  4. HotimahH Juvita HerdiantyJ Antibacterial test of ethanol extract gel preparation kencur rhizome (kaempferia galanga) against staphylococcus epidermidis.Strada J Pharm20246111310.30994/sjp.v6i1.107
     [Google Scholar]
  5. HidayatI.W. AstutiR.T. KusumaT.M. Product development of anti acne gel: Combination of white turmeric rhizome ethanol extract (curcuma mango val) and galangal rhizome ethanol extract(Alpinia Galanga).Urecol J. Part C Heal Sci202120211723
     [Google Scholar]
  6. RevolO. MilliezN. GerardD. Psychological impact of acne on 21st-century adolescents: Decoding for better care.Br. J. Dermatol.2015172Suppl. 1525810.1111/bjd.1374925702715
     [Google Scholar]
  7. YadavN. SinghA. ChatterjeeA. BelemkarS. Evaluation of efficacy and safety of perfact face gel and perfact face tablets in management of acne.J Clin Exp Dermatol.2011221000118
     [Google Scholar]
  8. StańkowskaA. Bergler-CzopB. Interleukins-6, -8 and -12p40 and c-reactive protein levels in patients with acne vulgaris with various severity of skin changes.Przegl. Dermatol.2020202030832210.5114/dr.2020.99876
     [Google Scholar]
  9. TasneemT. BegumA. ChowdhuryM.R.K. RahmanS. MacassaG. ManzoorJ. RashidM. Effects of acne severity and acne-related quality of life on depressive symptoms among adolescents and young adults: A cross-sectional study in Bangladesh.Front. Psychol.202314115310110.3389/fpsyg.2023.115310137554134
     [Google Scholar]
  10. RheeM.S. AlqamM.L. JonesB.C. PhadungpojnaS. DayD. HitchcockT.M. Characterization of a live Cutibacterium acnes subspecies defendens strain XYCM42 and clinical assessment as a topical regimen for general skin health and cosmesis.J. Cosmet. Dermatol.20232231031104510.1111/jocd.1551036374551
     [Google Scholar]
  11. WetariniK. Acne vulgaris in adults: A brief review on diagnosis and management.Int J Res Rev20202020246252
     [Google Scholar]
  12. YangJ.H. HwangE.J. MoonJ. YoonJ.Y. KimJ.W. ChoiS. ChoS.I. SuhD.H. Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: An 8-week, double-blinded, randomized, controlled trial.J. Dermatolog. Treat.202132329730110.1080/09546634.2019.165779231424962
     [Google Scholar]
  13. AlarikL. A IndiastutiDN AstariL SetyaningrumT. The effects of hormonal factor on the degree of acne vulgaris severity.Berkala Ilmu Kesehatan Kulit dan Kelamin202335212612910.20473/bikk.V35.2.2023.126‑129
     [Google Scholar]
  14. Del RossoJQ KircikL The primary role of sebum in the pathophysiology of acne vulgaris and its therapeutic relevance in acne management.J Dermatolog Treat2024351229685510.1080/09546634.2023.2296855
     [Google Scholar]
  15. YangJ.H. YoonJ.Y. KwonH.H. MinS. MoonJ. SuhD.H. Seeking new acne treatment from natural products, devices and synthetic drug discovery.Dermatoendocrinol201791e135652010.1080/19381980.2017.135652029484092
     [Google Scholar]
  16. SamodraG. AzizahL.N. Analysis antioxidant activity and total flavonoid content combination of ethanol extract of kencur rhizome (Kaempferiae Galanga L.) and tapak dara leaf (Catharanthus Roseus) using dpph method.IJHSRD20235212813810.36566/ijhsrd/Vol5.Iss2/186
     [Google Scholar]
  17. NuariD.A. SadinoA. AinayaS.H. The safety evaluation of some plants of the zingibereceae family.Bul Farmatera.202384363
     [Google Scholar]
  18. TanghettiE.A. The role of inflammation in the pathology of acne.J. Clin. Aesthet. Dermatol.201369273524062871
     [Google Scholar]
  19. AlmeriaY.V.R. Herbal Products for Acne Vulgaris: A Review.Int J Res Publ Rev20222022239257
     [Google Scholar]
  20. ProençaA.C. LuísÂ. DuarteA.P. The role of herbal medicine in the treatment of acne vulgaris: A systematic review of clinical trials.Evid. Based Complement. Alternat. Med.2022202212210.1155/2022/201194535754694
     [Google Scholar]
  21. SachdevaM. TanJ. LimJ. KimM. NadeemI. BismilR. The prevalence, risk factors, and psychosocial impacts of acne vulgaris in medical students: A literature review.Int. J. Dermatol.202160779279810.1111/ijd.1528033128470
     [Google Scholar]
  22. SinghA. SinghN. SinghS. SrivastavaR.P. SinghL. VermaP.C. DevkotaH.P. RahmanL. Kumar RajakB. SinghA. SaxenaG. The industrially important genus Kaempferia: An ethnopharmacological review.Front. Pharmacol.202314109952310.3389/fphar.2023.109952336923360
     [Google Scholar]
  23. SinghS. KhuranaA. ChitkaraA. Evaluation of serum levels of interleukins 6, 8, 17 and 22 in acne vulgaris: A cross-sectional study.Indian J. Dermatol.202368223310.4103/ijd.ijd_786_2137275817
     [Google Scholar]
  24. AskariN. GhazanfariT. YaraeeR. Vaez MahdaviM.R. SoroushM.R. Mohammad HassanZ. KhodashenasZ. ShamsJ. FaghihzadehS. Association between acne and serum pro-inflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in mustard gas-exposed patients: Sardasht-Iran cohort study.Arch. Iran Med.2017202869128193081
     [Google Scholar]
  25. LatifahS. FachrudinK. Ethnobotanical Study of Efficacious Plants in Urban Communities.Bristol, EnglandIOP Publishing2024012104
     [Google Scholar]
  26. SamaloRahayu GunaediTri RuntuboiDirk Y.P. Effectiveness of Ethanol Gel and Essential Oil of Kencur Rhizome (Kaempferia galanga L.) base Karbopol against Propionibacterium acnes.Quagga Jurnal Pendidikan dan Biologi20241613442
     [Google Scholar]
  27. HikmawantiN.P.E. Chemical component of Kencur (Kaemferia galanga L.) ethanolic extract using gas chromatography-mass spectrometry.IOP Conf. Ser.: Earth Environ. Sci.20218191012057
     [Google Scholar]
  28. KiptiyahS.Y. HarmayaniE. SantosoU. The effect of blanching and extraction method on total phenolic content, total flavonoid content and antioxidant activity of Kencur (Kaempferia galanga. L) extract.IOP Conf. Ser.: Earth Environ. Sci.20217091012025
     [Google Scholar]
  29. KristiantoS. BatoroJ. WidyartiS. SumitroS.B. Exploration and economic value of medicinal plants as traditional herbal ingredients in Bangselok, Madura, Indonesia.Proceedings of the International Conference on Industrial Engineering and Operations Management202038953902
     [Google Scholar]
  30. SalmahaminatiF.N. Chemical predictive modeling of ethyl-p-methoxycinnamate and synthesis of natural lotion from kencur (Kaempferia galanga L.) as sunscreen agents.J Ilm Pertan20232011724
     [Google Scholar]
  31. UtamiUH DjamiR RahmatD FajriahS SwandinyGF Identification and antibacterial activity of propionibacterium acnes of ethyl p-methoxy cinnamate isolated from Kaempferia Galanga Linn.J. Soc. Res.20232023194200
     [Google Scholar]
  32. SawalR.A.H. RahayuN.A. Evaluation of the Potential of Ethanol Extract of Kencur Leaves (Kaempferia galanga L.) as an Antimicrobial against Propionibacterium acnes using the Disk Diffusion Technique.J Farm Sains Indones.2023619319910.52216/jfsi.vol6no2p193‑199
     [Google Scholar]
  33. NayakR.K. Ethnomedicinal uses, phytochemical analysis and antibacterial activity of Kaempferia Galanga L. rhizome.Asian J. Microbiol. Biotechnol. Environ. Sci.202348124
     [Google Scholar]
  34. SaniS.A. Mohd FaikA.A. AbdullaR. KunasekaranS. Phytochemical, antioxidant and antibacterial activities of two kinds of Sabah Zingberaceae.J. Phys.: Conf. Ser.2019135801201210.1088/1742‑6596/1358/1/012012
     [Google Scholar]
  35. MohP. ZinM. ChoK. OoC. Phytochemical investigation and antimicrobial activities of Kaempferia Galanga L..J Myanmar Acad Arts Sci2019201920
     [Google Scholar]
  36. NurtjahtjaK. The antimicrobe of Kaempferia galanga L. rhizome against microsporum canis and staphylococcus epidermidis – in-vitro study.Int J Ecophysiol2023414044
     [Google Scholar]
  37. PhamNK NguyenHT NguyenQB A review on the ethnomedicinal uses, phytochemistry and pharmacology of plant species belonging to Kaempferia genus (Zingiberaceae).Pharm. Sci. Asia2021481124
     [Google Scholar]
  38. BaharY. BE MJ Testing on the effectiveness of anti acne gel (Acne vulgaris) mild and moderate degree acne from ethanol extract of galanga (Kaempferia galanga.L) in students at miftahus salam boarding school in banyumas.Int. J. Pharm.20157103107
     [Google Scholar]
  39. KumalaY.R. NuriefatinN. ShafiraD.A. Effectivity of Kaempferia Galanga L. essential oil against streptococcus pyogenes and streptococcus sanguinis for root canal medicament.Malaysian J. Med. Health Sci.2023202319
     [Google Scholar]
  40. RahmanI. KabirM.T. IslamM.N. MuqaddimM. SharminS. UllahM.S. Investigation of antioxidant and cytotoxic activities of kaempferia galanga L.Res J Pharm Technol.2019201900365.210.5958/0974‑360X.2019.00365.2
     [Google Scholar]
  41. HuangW. ZhengN. NiuN. TanY. LiY. TianH. Potent anti-angiogenic component in Kaempferia galanga L. and its mechanism of action.J. Ethnopharmacol.202432411781110.1016/j.jep.2024.11781138286156
     [Google Scholar]
  42. DrénoB. PécastaingsS. CorvecS. VeraldiS. KhammariA. RoquesC. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: A brief look at the latest updates.J. Eur. Acad. Dermatol. Venereol.201832S2Suppl. 251410.1111/jdv.1504329894579
     [Google Scholar]
  43. JinZ. SongY. HeL. A review of skin immune processes in acne.Front. Immunol.202314132493010.3389/fimmu.2023.132493038193084
     [Google Scholar]
  44. ChauhanP.N. SharmaA. RasheedH. MathurH. SharmaP. Treatment opportunities and technological progress prospective for acne vulgaris.Curr. Drug Deliv.20221307104835747981
     [Google Scholar]
  45. BarreaL. CacciapuotiS. MegnaM. VerdeL. MarascaC. VonoR. CamajaniE. ColaoA. SavastanoS. FabbrociniG. MuscogiuriG. The effect of the ketogenic diet on Acne: Could it be a therapeutic tool?Crit. Rev. Food Sci. Nutr.202464196850686910.1080/10408398.2023.217681336779329
     [Google Scholar]
  46. PopaG.L. Markers of oxidative stress in patients with acne: A literature review.Life202313MDPI1433
     [Google Scholar]
  47. MohsinN. HernandezL.E. MartinM.R. DoesA.V. NouriK. Acne treatment review and future perspectives.Dermatol. Ther.2022359e1571910.1111/dth.1571935841269
     [Google Scholar]
  48. SilinaL.V. PismennayaE.V. KolbinaM.S. Topical antibiotics for acne treatment.Vestn. Dermatol. Venerol.201692211512010.25208/0042‑4609‑2016‑92‑2‑115‑120
     [Google Scholar]
  49. SanjelK ZhangXM Progress of different treatment modalities to limit the use of antibiotics in the treatment of acne.Our Dermatol. Online20221312310.7241/ourd.20221.23
     [Google Scholar]
  50. KumarB. PathakR. MaryP.B. JhaD. SardanaK. GautamH.K. New insights into acne pathogenesis: Exploring the role of acne-associated microbial populations.Zhonghua Pifuke Yixue Zazhi2016342677310.1016/j.dsi.2015.12.004
     [Google Scholar]
  51. FabbrociniG. AnnunziataM.C. D’ArcoV. De VitaV. LodiG. MaurielloM.C. PastoreF. MonfrecolaG. Acne scars: Pathogenesis, classification and treatment.Dermatol. Res. Pract.2010201089308010.1155/2010/89308020981308
     [Google Scholar]
  52. BeylotC. AuffretN. PoliF. ClaudelJ.P. LecciaM.T. Del GiudiceP. DrenoB. Propionibacterium acnes : An update on its role in the pathogenesis of acne.J. Eur. Acad. Dermatol. Venereol.201428327127810.1111/jdv.1222423905540
     [Google Scholar]
  53. CongT.X. HaoD. WenX. LiX.H. HeG. JiangX. From pathogenesis of acne vulgaris to anti-acne agents.Arch. Dermatol. Res.2019311533734910.1007/s00403‑019‑01908‑x30859308
     [Google Scholar]
  54. AhleC.M. FeidenhanslC. BrüggemannH. Cutibacterium acnes.Trends Microbiol.202331441942010.1016/j.tim.2022.10.00636328874
     [Google Scholar]
  55. NieT. LeeA. Consider new topical treatments alongside existing options when treating acne vulgaris.Drugs Ther. Perspect.2022381043243610.1007/s40267‑022‑00941‑7
     [Google Scholar]
  56. BaldwinH. FarbergA. FreyC. HartmanC. LainE. MeltzerR. DraelosZ. Unmet Needs in the Management of Acne Vulgaris: A Consensus Statement.J. Drugs Dermatol.202322658258710.36849/JDD.758737276154
     [Google Scholar]
  57. BashirB. Advancements in dermatological therapies.J. Ther. Rehabil. Sci.202340313710.54393/tt.v4i03.137
     [Google Scholar]
  58. EidA.M. NaseefH. JaradatN. GhanimL. MoqadehR. YaseenM. Antibacterial and anti-acne activity of benzoyl peroxide nanoparticles incorporated in lemongrass oil nanoemulgel.Gels20239318610.3390/gels903018636975635
     [Google Scholar]
  59. AartsP. ReevesJ.L. ArdonC.B. van der ZeeH.H. PrensE.P. Clindamycin-benzoyl peroxide gel compared with clindamycin lotion for hidradenitis suppurativa: A randomized controlled assessor-blinded intra-patient pilot study.Dermatology2023239467067410.1159/00053075837080176
     [Google Scholar]
  60. EmmerichV.K. PurvisC.G. FeldmanS.R. An overview of adapalene and benzoyl peroxide once-daily topical gel as a therapeutic option for acne.Expert Opin. Pharmacother.202122131661166710.1080/14656566.2021.193967834086519
     [Google Scholar]
  61. SuubergA. Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris.Curr. Ther. Res. Clin. Exp.201990273110.1016/j.curtheres.2019.01.00830828405
     [Google Scholar]
  62. DalyA.U. Baptista GonçalvesR. LauE. BowersJ. HussainiN. CharalambidesM. CoumbeJ. FlohrC. LaytonA.M. A systematic review of isotretinoin dosing in acne vulgaris.JEADV Clin. Pract.20232343244910.1002/jvc2.154
     [Google Scholar]
  63. LiC. ChenJ. WangW. AiM. ZhangQ. KuangL. Use of isotretinoin and risk of depression in patients with acne: A systematic review and meta-analysis.BMJ Open201991e02154910.1136/bmjopen‑2018‑02154930670500
     [Google Scholar]
  64. AbozeidD. FawzyG. IssaM. AbdeltawabN. SolimanF. Medicinal plants and their constituents in the treatment of Acne vulgaris.Biointerface Res. Appl. Chem.20232023189
     [Google Scholar]
  65. LaytonA.M. AlexisA. BaldwinH. BettoliV. Del RossoJ. DirschkaT. The personalized acne treatment tool — recommendations to facilitate a patient-centered approach to acne management from the Personalizing Acne: Consensus of experts.JAAD Int2023126069
     [Google Scholar]
  66. AkmanA. DurusoyC. SenturkM. KocC.K. SoyturkD. AlpsoyE. Treatment of acne with intermittent and conventional isotretinoin: A randomized, controlled multicenter study.Arch. Dermatol. Res.20072991046747310.1007/s00403‑007‑0777‑217710426
     [Google Scholar]
  67. KhairullahAR SolikhahTI AnsoriANM HanisiaRH PuspitaraniGA FadhollyA Medicinal importance of Kaempferia Galanga L. (zingiberaceae): A comprehensive review.J. HerbMed Pharmacol.20212021281288
     [Google Scholar]
  68. CahyawatiPN Efek analgetik dan antiinflamasi Kaempferia Galanga (Kencur)..WICAKSANA J Lingkung dan Pembang.20202020411519
     [Google Scholar]
  69. SubositiD. KurnianingrumN. MujahidR. WidiyastutiY. Kaempferia galanga L. A medicinal plant used by Indonesian ethnic groups: Genetic diversity based on inter-simple sequence repeats (ISSR).Agrivita20204214552
     [Google Scholar]
  70. ElyaB. KusumaI.M. JufriM. HandayaniR. Antibacterial tests against acne in vitro , the physical stability and patch test using cream containing ethyl p-methoxycinnamate extracted from Kaempferia galanga L., Rhizoma.Res. J. Med. Plant20162016426434
     [Google Scholar]
  71. SuvanprakornP. TongyenT. PrakhongcheepO. LaoratthaphongP. ChanvorachoteP. Establishment of an anti-acne vulgaris evaluation method based on TLR2 and TLR4-mediated Interleukin-8 production. in vivo 201933619291934
     [Google Scholar]
  72. RavisankarP. KoushikO.S. HimajaV. RameshJ. PragnaP. Acne-causes and amazing remedial measures for acne.J. Pharm. Res.20155209301
     [Google Scholar]
/content/journals/ctm/10.2174/0122150838312102241008055759
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Investigating the Influence of 0.75% Ethanol Extract Gel from “Kaempferia galanga L Rhizoma” on Mild and Moderate Acne Vulgaris Among High School Students
Current Traditional Medicine 12, E22150838312102 (2026); https://doi.org/10.2174/0122150838312102241008055759
/content/journals/ctm/10.2174/0122150838312102241008055759
/content/journals/ctm/10.2174/0122150838312102241008055759
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  • Article Type:     Research Article
Keyword(s): acne treatment; acne vulgaris; degree of inflammation; ethanol extract; il-8; image j; Kencur (kaempferia galanga l rhizoma)

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