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2000
Volume 11, Issue 6
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846

Abstract

Thymol, also known as 2-isopropyl-5-methylphenol, is a secondary metabolite found in plants, particularly in the family, like thyme, peppermint, sage, and lavender. As a terpene, it contributes to the aroma, flavor, and color of plants while also serving as a natural defense mechanism against pests, diseases, and environmental threats. Thymol exhibits bioactive properties, including antiseptic, anti-bacterial, anti-fungal, and anti-inflammatory effects, making it valuable for treating various infections and diseases. Additionally, thymol is utilized in personal care products and functions as a preservative in foods and pharmaceuticals. The objective of this study is to give an overview based on patent analysis and a patent review of thymol’s innovative health and medicine applications. We analyze data from patent documents that highlight the thymol extraction process and its applications in the fields of health and medicine. Data were extracted from different specialized patent databases. After patent analysis, a selection of relevant patents for thymol has been made. Finally, to propose relevant health-related patent documents, sorting was realized using the International Patent Classification (IPC). The study focused on the medicinal purposes of thymol. Our results present a statistical study of 2,319 patent documents published between 1972 and 2023. Thus, IPC data show that 82% of the codes assigned to the documents studied concern preparations for medical, dental, or toilet preparations. The first part of the patent documents that have been presented illustrates thymol’s natural or synthetic origin, and the second part shows its therapeutic applications. Thymol’s bioactivities make it a useful natural candidate for pharmaceutical formulation as well as for cosmetic compositions. Document patents, as presented in this study, affirm thymol’s therapeutic potential, positioning it as a promising natural candidate for pharmaceutical formulations. This is particularly evident in its efficacy against resistant bacteria in anti-microbial therapeutic compositions, its role as an anti-tumoral and cell regenerator in cancer patients, and its integration into personal care products as well as skin care formulations.

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2024-07-15
2026-01-04

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References

  1. AbdelhalimA. HanrahanJ. Biologically active compounds from Lamiaceae family: Central nervous system effects. RahmanAtta-Ur. Studies in Natural Products Chemistry (Bioactive Natural Products)AmsterdamElsevier202168255315
     [Google Scholar]
  2. El BoukhariR. FatimiA. Patent analysis of four Lamiaceae-derived plants: A medicinally active resource against new health challenges.Med. Sci. Forum.20232111
     [Google Scholar]
  3. JamiołkowskaA. KopackiM. Natural Compounds Against Plant Pests and Pathogens.Natural Remedies for Pest, Disease and Weed Control. EgbunaC. SawickaB. LondonAcademic Press2020556310.1016/B978‑0‑12‑819304‑4.00005‑1
     [Google Scholar]
  4. Abhishek BiswalR. PazhamalaiV. Thymol.A Centum of Valuable Plant Bioactives. MushtaqM. AnwarF. LondonAcademic Press202127529010.1016/B978‑0‑12‑822923‑1.00015‑7
     [Google Scholar]
  5. National Center for Biotechnology Information. PubChem: Compound Summary for CID 6989, Thymol.Available from: https://pubchem.ncbi.nlm.nih.gov/compound/thymol (accessed on December 25, 2023).
  6. MarcheseA. OrhanI.E. DagliaM. BarbieriR. Di LorenzoA. NabaviS.F. GortziO. IzadiM. NabaviS.M. Antibacterial and antifungal activities of thymol: A brief review of the literature.Food Chem.201621040241410.1016/j.foodchem.2016.04.11127211664
     [Google Scholar]
  7. BoyeA. AddoJ.K. AcheampongD.O. ThomfordA.K. AsanteE. AmoaningR.E. KumaD.N. The hydroxyl moiety on carbon one (C1) in the monoterpene nucleus of thymol is indispensable for anti-bacterial effect of thymol.Heliyon202063e0349210.1016/j.heliyon.2020.e0349232195386
     [Google Scholar]
  8. TianL. WangX. LiuR. ZhangD. WangX. SunR. GuoW. YangS. LiH. GongG. Antibacterial mechanism of thymol against Enterobacter sakazakii.Food Control202112310771610.1016/j.foodcont.2020.107716
     [Google Scholar]
  9. MastelićJ. JerkovićI. BlaževićI. Poljak-BlažiM. BorovićS. Ivančić-BaćeI. SmrečkiV. ŽarkovićN. Brčić-KosticK. Vikić-TopićD. MüllerN. Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives.J. Agric. Food Chem.200856113989399610.1021/jf073272v18473475
     [Google Scholar]
  10. YazarluO. IranshahiM. KashaniH.R.K. ReshadatS. HabtemariamS. IranshahyM. HasanpourM. Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review.Pharmacol. Res.202117410584110.1016/j.phrs.2021.10584134419563
     [Google Scholar]
  11. RiellaK.R. MarinhoR.R. SantosJ.S. Pereira-FilhoR.N. CardosoJ.C. Albuquerque-JuniorR.L.C. ThomazziS.M. Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents.J. Ethnopharmacol.2012143265666310.1016/j.jep.2012.07.02822885071
     [Google Scholar]
  12. HassanH.F.H. MansourA.M. SalamaS.A. El-SayedE.S.M. The chemopreventive effect of thymol against dimethylhydrazine and/or high fat diet-induced colon cancer in rats: Relevance to NF-κB.Life Sci.202127411933510.1016/j.lfs.2021.11933533713663
     [Google Scholar]
  13. EscobarA. PérezM. RomanelliG. BlusteinG. Thymol bioactivity: A review focusing on practical applications.Arab. J. Chem.202013129243926910.1016/j.arabjc.2020.11.009
     [Google Scholar]
  14. Sedaghat DoostA. Van CampJ. DewettinckK. Van der MeerenP. Production of thymol nanoemulsions stabilized using Quillaja Saponin as a biosurfactant: Antioxidant activity enhancement.Food Chem.201929313414310.1016/j.foodchem.2019.04.09031151593
     [Google Scholar]
  15. NajaflooR. BehyariM. ImaniR. NourS. A mini-review of Thymol incorporated materials: Applications in antibacterial wound dressing.J. Drug Deliv. Sci. Technol.20206010190410.1016/j.jddst.2020.101904
     [Google Scholar]
  16. AhmadA. ElishaI.L. van VuurenS. ViljoenA. Volatile phenolics: A comprehensive review of the anti-infective properties of an important class of essential oil constituents.Phytochemistry202119011286410.1016/j.phytochem.2021.11286434311279
     [Google Scholar]
  17. SilvaA.S. TewariD. SuredaA. SuntarI. BelwalT. BattinoM. NabaviS.M. NabaviS.F. The evidence of health benefits and food applications of Thymus vulgaris L.Trends Food Sci. Technol.202111721822710.1016/j.tifs.2021.11.010
     [Google Scholar]
  18. US Food and Drug Administration. Substances added to food (formerly EAFUS).Available from: https://www.cfsanappsexternal.fda.gov/scripts/fdcc/?set=FoodSubstances&id=THYMOL&sort=Sortterm_ID&order=ASC&startrow=1&type=basic&search=thymol (accessed on December 26, 2023).
  19. European Commission : Directorate-General for Research and InnovationInnovating for sustainable growth : A bioeconomy for Europe.Publications Office of the EU2012
     [Google Scholar]
  20. AguilarA. MagnienE. ThomasD. Thirty years of European biotechnology programmes: from biomolecular engineering to the bioeconomy.N. Biotechnol.201330541042510.1016/j.nbt.2012.11.01423195849
     [Google Scholar]
  21. United States Patent and Trademark Office. USPTO Database (PatFT-AppFT).Available from: https://uspto.gov/patents/search (accessed on June 11, 2023).
  22. European Patent Office. Espacenet Patent Search.Available from: https://worldwide.espacenet.com (accessed on June 11, 2023).
  23. World Intellectual Property OrganizationThe Patentscope.Available from: https://patentscope.wipo.int (accessed on January 8, 2024).
     [Google Scholar]
  24. Cambia Institute. The Lens Patent Data Set.Available from: www.lens.org (accessed on January 8, 2024).
  25. World Intellectual Property Organization. IPC Publication.Available from: www.wipo.int/classifications/ipc/ipcpub (accessed on July 30, 2023).
  26. Anonymous InventorOintment contg horse fat and thymol having antiseptic antirheumatic etc effects.Patent DE2123525A11972
  27. El BoukhariR. FatimiA. A review of the patentability of rosemary-derived drugs and bioactive compounds.Drugs and Drug Candidates20232117218810.3390/ddc2010011
     [Google Scholar]
  28. DutfieldG. Collective invention and patent law individualism: Origins and functions of the inventor’s right of attribution.WIPO J.201352534
     [Google Scholar]
  29. World Intellectual Property OrganizationGuide to the International Patent Classification (IPC)Geneva, SwitzerlandWIPO202051
     [Google Scholar]
  30. El BoukhariR. FatimiA. Extract of rosemary as food additive: The landmark patents.Biol. Lif. Sci. Forum.202326137
     [Google Scholar]
  31. El BoukhariR. FatimiA. Analysis of lavender-related patent documents.J. Analyt. Sci. Appl. Biotechnol.2023512028
     [Google Scholar]
  32. Sanchez-EsguaG. Reyes-AlvarezJ. Perez-SantosM. Patenting trends in the pharmaceutical field of Mexican universities.Pharm. Pat. Anal.2023121375010.4155/ppa‑2022‑004836722324
     [Google Scholar]
  33. BeltranE. SerafiniM.R. AlvesI.A. Aragón NovoaD.M. Novel synthesized tyrosinase inhibitors: A systematic patent review (2012-present).Curr. Med. Chem.202431330833510.2174/092986733066623020311143736740802
     [Google Scholar]
  34. FatimiA. Chitosan-based hydrogels: Patent analysis.Mat. Proc.2022911
     [Google Scholar]
  35. FatimiA. Patentability of biopolymer-based hydrogels.Chem. Proc.20228139
     [Google Scholar]
  36. FatimiA. Hydrogel-based bioinks for three-dimensional bioprinting: Patent analysis.Mat. Proc.2021713
     [Google Scholar]
  37. PritamM. SanghamitraJ. SamarendraD. Status of innovations in global dentistry over 150 years using patent landscaping analysis.HIV Nursing.202323310241028
     [Google Scholar]
  38. Hachimi AlaouiC. FatimiA. A 20-year patent review and innovation trends on hydrogel-based coatings used for medical device biofabrication.J. Biomater. Sci. Polym. Ed.20233491255127310.1080/09205063.2022.216177736542377
     [Google Scholar]
  39. European Patent Office. Espacenet Glossary.Available from: https://worldwide.espacenet.com/patent/help/espacenet-glossary (accessed on August 25, 2023).
  40. JingS RongfeiZ RujuanL. A kind of Thymol extraction process for extracting.CN109045748A,2018
  41. NinkovD. Pesticidal Compounds and Compositions.Granted Patent: EP1353552B1,2007
  42. KaiY YugangJ YongguangW ZhiminG ZhixiangL CongmingL Thymol and preparation method and pharmaceutical composition thereof.CN108911951B,2021
  43. NabiN GaffarA LucchesiS AfflittoJJ HerlesSM Oral compositions for plaque and gingivitis.US5472684A,1995
  44. Khanujasps Srivastavas Shasneyak Formulation comprising thymol useful in the treatment of drug resistant bacterial infections.Granted Patent: US6514541B2,2003
  45. Ok PyoZ Young HoonJ Kang RoL Thymol derivatives having anti-tumor activity, and anti-cancer agent comprising the same.US6255517B1,2001
  46. RemmalA. Pharmaceutical composition comprising an antitumoral agent and an active agent selected especially among carveol, thymol and carvacrol.Granted Patent: EP1879656B1,2012
  47. RivkinH. Lotion for blemished skin (comprising thymol).Granted Patent: EP0186258B1,1991
  48. TalwarAK CarlinEJ Taste masking of thymol.ZA891185B,1989
  49. YeonsuJ BongsooP Composition for relieving itch or irritation of skin, comprising thymol trimethoxycinnamate.US11583512B2,2023
  50. El BoukhariR. FatimiA. Carvacrol: Innovative synthesis pathways and overview of its patented applications.Recent Pat. Biotechnol.20241811510.2174/0118722083292888240223094707
     [Google Scholar]
  51. El BoukhariR. FatimiA. Extraction methods applied to natural Lamiaceae-derived compounds: An overview based on patents.Eng. Proc.202356179
     [Google Scholar]
  52. Nagoor MeeranM.F. JavedH. Al TaeeH. AzimullahS. OjhaS.K. Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development.Front. Pharmacol.2017838010.3389/fphar.2017.0038028694777
     [Google Scholar]
  53. KowalczykA. PrzychodnaM. SopataS. BodalskaA. FeckaI. Thymol and thyme essential oil—new insights into selected therapeutic applications.Molecules20202518412510.3390/molecules2518412532917001
     [Google Scholar]
  54. SampaioL.A. PinaL.T.S. SerafiniM.R. Antitumor effects of carvacrol and thymol: a systematic review.Front. Pharmacol.2021202112
     [Google Scholar]
  55. De La ChapaJ.J. SinghaP.K. LeeD.R. GonzalesC.B. Thymol inhibits oral squamous cell carcinoma growth via mitochondria‐mediated apoptosis.J. Oral Pathol. Med.201847767468210.1111/jop.1273529777637
     [Google Scholar]
  56. ScholzA. Nav1.7 Voltage - Gated Sodium Channel.xPharm: The Comprehensive Pharmacology Reference. EnnaS.J. BylundD.B. New YorkElsevier200716
     [Google Scholar]
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Thymol’s Innovative Health and Medicine Applications: An Overview Based on Patent Analysis and Patent Review
Current Traditional Medicine 11, E150724231962 (2025); https://doi.org/10.2174/0122150838308279240710053635
/content/journals/ctm/10.2174/0122150838308279240710053635
/content/journals/ctm/10.2174/0122150838308279240710053635
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  • Article Type:     Review Article
Keyword(s): bioactivity; biochemistry; biotechnology; international patent classification (IPC); Lamiaceae; patent analysis; thymol

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