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Volume 11, Issue 5
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846
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Abstract

is one of the largest genera in the Leguminosae (Fabaceae) family, with a wide range of distribution in temperate and tropical climates. This review examines the literature from 2000 to 2021 and focuses on medicinal uses, pharmacological research, and flavonoids extracted from species. The review also highlights existing knowledge gaps in species research, which could help speed up future studies aiming at discovering lead chemicals from these species. species are used as pesticides, animal feed additions, and to improve soil fertility through nitrogen fixation. Furthermore, species are frequently used in traditional medicine to treat ailments such as gastro-duodenal disorders, chest pains, chronic diarrhoea, inflammatory disorders, skin disorders, wounds, dysmenorrhea, asthma, elephantiasis, haemorrhoids, and bronchitis. Several recent pharmacological studies have established their efficacy as anti-plasmodium, anti-cancer, anti-protozoal, antibacterial, antifungal, and anti-insecticidal drugs. Furthermore, flavonoids isolated from these species have been proven to exhibit anti-plasmodia, anticancer, and anti-insecticidal properties, supporting the majority of species' traditional applications. Over 140 flavonoids have been identified and isolated from approximately 25 species to date. The majority of the isolated flavonoids have -substituted, C-methylated, or prenylated patterns and are flavonol, chalcone, flavone, or flavanone. Notably, some of the flavonoids with unique skeletal structures were discovered for the first time in the species. Most of the reported biological activity, however, requires further testing against a wide range of diseases, though they can be recommended as possible promising compounds.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/ctm/10.2174/0122150838279617231213042843
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Comprehensive Review of the Ethnomedicinal Uses and Pharmacological Effects of Flavonoids of Tephrosia species
Current Traditional Medicine 11, E150124225555 (2025); https://doi.org/10.2174/0122150838279617231213042843
/content/journals/ctm/10.2174/0122150838279617231213042843
/content/journals/ctm/10.2174/0122150838279617231213042843
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  • Article Type:     Review Article
Keyword(s): chronic diarrhoea; Ethnomedicinal uses; flavonoids; genus Tephrosia; inflammatory disorders; pharmacological effects

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