1,3,5-Triazine Analogs: A Potent Anticancer Scaffold

Background: This review presents the exhaustive exploration of 1,3,5-triazine scaffold for development of analogs of anticancer drugs, over the last century. In the recent years, striazine moiety has been one of the most studied moiety, showing broad-spectrum pharmacological activities such as antibacterial, antifungal, analgesic, anti-HIV, antileishmanial, antitrypanosomal, antimalarial and antiviral. Nowadays, many boffins are have become interested in novel synthesis of s-triazine derivatives because of low cost and ease of availability. Methods: This scaffold has been extensively investigated mainly in the past decade. Many products have been synthesized from different starting materials and these synthetic products possess anticancer potential against various cell lines. Results: Many 1,3,5-triazine analogs exhibited significant anticancer activity in various models and cell lines exhibiting different mechanisms. Some analogs have also shown good pharmacokinetic parameters with less IC50 values. Conclusion: Various 1,3,5-triazine analogs have shown potent activities and may be regarded as clinical candidates for future anticancer formulations. This review may be helpful to those researchers seeking required information with regard to the drug design and medicinal properties of 1,3,5-triazine derivatives for selected targets. This review may also offer help to find and improve clinically viable anticancer molecules.