Skip to content
2000
Volume 20, Issue 8
  • ISSN: 1574-888X
  • E-ISSN: 2212-3946

Abstract

Vascular stents and stem cells have been used in high-acuity cases for many decades, particularly in cardiology. Providing the physician with another avenue of treatment, they have had a reasonable amount of success. However, there has been very little research conducted on seeding vascular stents with stem cells when treating intracranial aneurysms. Our work aims to understand the current literature available on the viability of such stents and the future directions one should take when choosing stents seeded with stem cells. Three computerized searches in PubMed were used. Four papers met the criteria, and two were excluded. There have been some experiments where the efficacy of vascular stents seeded with different materials was tested. G/PLL-coated stents provided multiple advantages and bioactive benefits to the mesenchymal stem cells. On the other hand, SF/SDF-1α also promoted similar benefits but provoked multiple unwanted inflammatory responses. G/PLL and SF/SDF-1α coated stents were able to provide satisfactory results but still require more extensive research to thoroughly understand their efficacies and safety. Future directions may include researching and discovering a wider array of biocompatible materials to seed the stents.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cscr/10.2174/011574888X329158241015053444
2025-01-09
2025-12-08

  • From This Site

    /content/journals/cscr/10.2174/011574888X329158241015053444
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. FargenK.M. Soriano-BaronH.E. RushingJ.T. MackW. MoccoJ. AlbuquerqueF. DucruetA.F. MokinM. LinfanteI. WolfeS.Q. WilsonJ.A. HirschJ.A. A survey of intracranial aneurysm treatment practices among United States physicians.J. Neurointerv. Surg.2018101444910.1136/neurintsurg‑2016‑01280828184003
     [Google Scholar]
  2. MokinM. PrimianiC.T. RenZ. PiperK. FiorellaD.J. RaiA.T. OrlovK. KislitsinD. GorbatykhA. MoccoJ. De LeacyR. LeeJ. Vargas MachajJ. TurnerR. ChaudryI. TurkA.S. Stent-assisted coiling of cerebral aneurysms: multi-center analysis of radiographic and clinical outcomes in 659 patients.J. Neurointerv. Surg.202012328929710.1136/neurintsurg‑2019‑01518231530655
     [Google Scholar]
  3. SarathyD. Update on Clinical Management with Neurovascular Stents.J. Exp. Neurol.2022324959
     [Google Scholar]
  4. BrinjikjiW. KallmesD.F. KadirvelR. Mechanisms of healing in coiled intracranial aneurysms: a review of the literature.AJNR Am. J. Neuroradiol.20153671216122210.3174/ajnr.A417525430855
     [Google Scholar]
  5. BavinzskiG. TalazogluV. KillerM. RichlingB. GruberA. GrossC.E. PlenkH.Jr Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils.J. Neurosurg.199991228429310.3171/jns.1999.91.2.028410433317
     [Google Scholar]
  6. RaymondJ. VenneD. AllasS. RoyD. OlivaV.L. DenbowN. SalazkinI. LeclercG. Healing mechanisms in experimental aneurysms. I. Vascular smooth muscle cells and neointima formation.J. Neuroradiol.199926172010363438
     [Google Scholar]
  7. AdibiA. SenA. MithaA.P. Cell Therapy for Intracranial Aneurysms: A Review.World Neurosurg.20168639039810.1016/j.wneu.2015.10.08226547001
     [Google Scholar]
  8. RaymondJ. DarsautT. SalazkinI. GevryG. BouzeghraneF. Mechanisms of occlusion and recanalization in canine carotid bifurcation aneurysms embolized with platinum coils: an alternative concept.AJNR Am. J. Neuroradiol.200829474575210.3174/ajnr.A090218202238
     [Google Scholar]
  9. TianZ. LiuJ. ZhangY. ZhangY. ZhangX. ZhangH. YangM. YangX. WangK. Risk Factors of Angiographic Recurrence After Endovascular Coil Embolization of Intracranial Saccular Aneurysms: A Retrospective Study Using a Multicenter Database.Front. Neurol.202011102610.3389/fneur.2020.0102633041975
     [Google Scholar]
  10. AbdihalimM. WatanabeM. ChaudhryS.A. JagadeesanB. SuriM.F.K. QureshiA.I. Are coil compaction and aneurysmal growth two distinct etiologies leading to recurrence following endovascular treatment of intracranial aneurysm?J. Neuroimaging201424217117510.1111/j.1552‑6569.2012.00786.x23317437
     [Google Scholar]
  11. WollertK.C. DrexlerH. Clinical applications of stem cells for the heart.Circ. Res.200596215116310.1161/01.RES.0000155333.69009.6315692093
     [Google Scholar]
  12. BhattacharyaN. Fetal cell/tissue therapy in adult disease: a new horizon in regenerative medicine.Clin. Exp. Obstet. Gynecol.200431316717315491058
     [Google Scholar]
  13. PengQ. GuoR. ZhouY. TengR. CaoY. MuS. Comparison of Gelatin/Polylysine-and Silk Fibroin/SDF-1 α -Coated Mesenchymal Stem Cell-Seeded Intracranial Stents.Macromol. Biosci.2023234220040210.1002/mabi.20220040236541928
     [Google Scholar]
  14. MetzR.P. PattersonJ.L. WilsonE. Vascular smooth muscle cells: Isolation, culture, and characterization.Methods Mol Biol.201284316917610.1007/978‑1‑61779‑523‑7_16
     [Google Scholar]
  15. MarbacherS. FrösénJ. MarjamaaJ. AnisimovA. HonkanenP. von GuntenM. Abo-RamadanU. HernesniemiJ. NiemeläM. Intraluminal cell transplantation prevents growth and rupture in a model of rupture-prone saccular aneurysms.Stroke201445123684369010.1161/STROKEAHA.114.00660025370586
     [Google Scholar]
  16. CorteseJ. RasserC. EvenG. BardetS.M. ChoqueuxC. MesnierJ. PerrinM.L. JanotK. CaroffJ. NicolettiA. MichelJ.B. SpelleL. CaligiuriG. RouchaudA. CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing.Stroke202152267768610.1161/STROKEAHA.120.03062433412905
     [Google Scholar]
  17. YangY. GaoP. WangJ. TuQ. BaiL. XiongK. QiuH. ZhaoX. MaitzM.F. WangH. LiX. ZhaoQ. XiaoY. HuangN. YangZ. Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy.Research202020202020/920390610.34133/2020/920390632405627
     [Google Scholar]
  18. ZhuW. TianY. ZhouL.F. WangY. SongD. MaoY. YangG.Y. Development of a novel endothelial cell-seeded endovascular stent for intracranial aneurysm therapy.J. Biomed. Mater. Res. A200885A371572110.1002/jbm.a.3159217876775
     [Google Scholar]
  19. PanchendraboseK. MuramS. MithaA.P. Promoting endothelialization of flow-diverting stents: a review.J. Neurointerv. Surg.2021131869010.1136/neurintsurg‑2020‑01587432487770
     [Google Scholar]
  20. PanchendraboseK. MuramS. BelangerB.L. EesaM. AlmekhlafiM.A. GoyalM. WongJ.H. SenA. MenonB.K. HarB. MithaA.P. Intra-arterial injection of mesenchymal stem cells to accelerate neointima formation after endovascular stenting in a rabbit model.J. Neurosurg.2022137369169810.3171/2021.11.JNS21237235090127
     [Google Scholar]
  21. HouK. LiG. LvX. XuB. XuK. YuJ. Delayed rupture of intracranial aneurysms after placement of intra-luminal flow diverter.Neuroradiol. J.202033645146410.1177/197140092095329932851918
     [Google Scholar]
  22. UccelliA. MorettaL. PistoiaV. Mesenchymal stem cells in health and disease.Nat. Rev. Immunol.20088972673610.1038/nri239519172693
     [Google Scholar]
  23. LaluM.M. McIntyreL. PuglieseC. FergussonD. WinstonB.W. MarshallJ.C. GrantonJ. StewartD.J. Canadian Critical Care Trials Group Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials.PLoS One2012710e4755910.1371/journal.pone.004755923133515
     [Google Scholar]
  24. KeatingA. Mesenchymal stromal cells.Curr. Opin. Hematol.200613641942510.1097/01.moh.0000245697.54887.6f17053453
     [Google Scholar]
  25. ArabpourM. SaghazadehA. RezaeiN. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes.Int. Immunopharmacol.20219710782310.1016/j.intimp.2021.10782334102486
     [Google Scholar]
  26. SofiaS. McCarthyM.B. GronowiczG. KaplanD.L. Functionalized silk-based biomaterials for bone formation.J. Biomed. Mater. Res.200154113914810.1002/1097‑4636(200101)54:1<139::AID‑JBM17>3.0.CO;2‑711077413
     [Google Scholar]
/content/journals/cscr/10.2174/011574888X329158241015053444
Loading

  • Article Type:     Review Article
Keyword(s): endovascular; intracranial aneurysms, biocompatible materials, G/PLL-coated stents; Stem cells; vascular stents

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test