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2000
Volume 18, Issue 3
  • ISSN: 1874-4710
  • E-ISSN: 1874-4729

Abstract

Aim

This study intended to compare the radiation dose estimates to target and non-target liver compartments from 99mTc-MAA SPECT/CT and 90Y-PET/MR scans in liver tumors treated by 90Y-glass microspheres.

Materials and Methods

Dose estimation was performed for twenty-three eligible patients (13M, 10F) after 99mTc-MAA simulation using SPECT/CT imaging, and over 90Y-PET/MR images after 90Y-microsphere therapy. Simplicit90Y™ software was used for voxel-based dosimetry over the liver parenchyma. Dose estimates were obtained for whole healthy liver (HL), healthy injected liver (HIL), and tumor volumes. Pearson correlation, Bland–Altman plot, and Wilcoxon signed-ranks test were used for statistical analysis.

Results

The mean tumor dose was 270 ± 111 Gy, the whole liver parenchyma dose was 26 ± 12 Gy, and the healthy injected liver dose was 55 ± 18 Gy from 99mTc-MAA simulation. 90Y-PET/MR dosimetry yielded a mean tumor dose of 271 ± 125 Gy, a HIL mean dose of 54±18 Gy, and a liver parenchyma dose of 25 ± 12 Gy. An excellent agreement was demonstrated between tumor doses (=0.90) and liver doses (=0.87), while the agreement was less for HIL doses (=0.80). Wilcoxon signed-ranks test yielded no significant difference between the dose estimates for all liver compartments.

Conclusion

It was deduced that 99mTc-MAA SPECT/CT simulation provides valuable dose prediction in 90Y-glass microsphere therapy. Despite the difference in volume measurements and dose estimates with 90Y-PET/MR, the predictive value of the 99mTc-MAA simulation was not affected.

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2025-09-05

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References

  1. AhmadzadehfarH. BiersackH.J. EzziddinS. Radioembolization of liver tumors with yttrium-90 microspheres.Semin. Nucl. Med.201040210512110.1053/j.semnuclmed.2009.11.00120113679
     [Google Scholar]
  2. AlexanderS. Imaging in medical diagnosis and therapy.MD Handbook of RadioembolizationTaylor & Francis GroupRoutledge2017
     [Google Scholar]
  3. BombardieriE. Clinical Applications of Nuclear Medicine Targeted Therapy.Springer2017
     [Google Scholar]
  4. WeberM. LamM. ChiesaC. KonijnenbergM. CremonesiM. FlamenP. GnesinS. BodeiL. KracmerovaT. LusterM. GarinE. HerrmannK. EANM procedure guideline for the treatment of liver cancer and liver metastases with intra-arterial radioactive compounds.Eur. J. Nucl. Med. Mol. Imaging20224951682169910.1007/s00259‑021‑05600‑z35146577
     [Google Scholar]
  5. KimS.P. CohalanC. KopekN. EngerS.A. A guide to 90Y radioembolization and its dosimetry.Phys. Med.20196813214510.1016/j.ejmp.2019.09.23631785502
     [Google Scholar]
  6. RoeskeJ.C. AydoganB. BardiesM. HummJ.L. Small-scale dosimetry: Challenges and future directions.Semin. Nucl. Med.200838536738310.1053/j.semnuclmed.2008.05.00318662558
     [Google Scholar]
  7. HashikinN.A.A. YeongC.H. GuatelliS. AbdullahB.J.J. NgK.H. MalarodaA. RosenfeldA. PerkinsA.C. Systematic investigation on the validity of partition model dosimetry for 90 Y radioembolization using Monte Carlo simulation.Phys. Med. Biol.201762187342735610.1088/1361‑6560/aa7e5b28686171
     [Google Scholar]
  8. WondergemM. SmitsM.L.J. ElschotM. de JongH.W.A.M. VerkooijenH.M. van den BoschM.A.A.J. NijsenJ.F.W. LamM.G.E.H. 99mTc-macroaggregated albumin poorly predicts the intrahepatic distribution of 90Y resin microspheres in hepatic radioembolization.J. Nucl. Med.20135481294130110.2967/jnumed.112.11761423749996
     [Google Scholar]
  9. SongY.S. PaengJ.C. KimH.C. ChungJ.W. CheonG.J. ChungJ.K. LeeD.S. KangK.W. PET/CT-based dosimetry in 90Y-microsphere selective internal radiation therapy: Single cohort comparison with pretreatment planning on (99m)Tc-MAA imaging and correlation with treatment efficacy.Medicine20159423e94510.1097/MD.000000000000094526061323
     [Google Scholar]
  10. GnesinS. CanettiL. AdibS. CherbuinN. Silva MonteiroM. BizeP. DenysA. PriorJ.O. BaechlerS. BoubakerA. Partition model-based 99mTc-MAA SPECT/CT predictive dosimetry compared with 90Y TOF PET/CT posttreatment dosimetry in radioembolization of hepatocellular carcinoma: A quantitative agreement comparison.J. Nucl. Med.201657111672167810.2967/jnumed.116.17310427307346
     [Google Scholar]
  11. KaoY.H. Hock TanA.E. BurgmansM.C. IraniF.G. KhooL.S. Gong LoR.H. TayK.H. TanB.S. Hoe ChowP.K. Eng NgD.C. Whatt GohA.S. Image-guided personalized predictive dosimetry by artery-specific SPECT/CT partition modeling for safe and effective 90Y radioembolization.J. Nucl. Med.201253455956610.2967/jnumed.111.09746922343503
     [Google Scholar]
  12. Van AudenhaegeK. Van HolenR. VandenbergheS. VanhoveC. MetzlerS.D. MooreS.C. Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging.Med. Phys.20154284796481310.1118/1.492706126233207
     [Google Scholar]
  13. SimanW. MikellJ.K. KappadathS.C. Practical reconstruction protocol for quantitative 90 Y bremsstrahlung SPECT/CT.Med. Phys.20164395093510310.1118/1.496062927587040
     [Google Scholar]
  14. RongX. DuY. FreyE.C. A method for energy window optimization for quantitative tasks that includes the effects of model-mismatch on bias: Application to Y-90 bremsstrahlung SPECT imaging.Phys. Med. Biol.201257123711372510.1088/0031‑9155/57/12/371122617760
     [Google Scholar]
  15. LjungbergM. A review has summarized (3D) image based dosimetry into the general methodologies that constitutes local deposition methods, dose-kernel convolutions, and MC simulations.IEEE Trans. Radiat. Plasma Med. Sci.201826
     [Google Scholar]
  16. BaileyD.L. WillowsonK.P. Quantitative SPECT/CT: SPECT joins PET as a quantitative imaging modality.Eur. J. Nucl. Med. Mol. Imaging201441S1Suppl. 1172510.1007/s00259‑013‑2542‑424037503
     [Google Scholar]
  17. DezarnW.A. CessnaJ.T. DeWerdL.A. FengW. GatesV.L. HalamaJ. KennedyA.S. NagS. SarfarazM. SehgalV. SelwynR. StabinM.G. ThomadsenB.R. WilliamsL.E. SalemR. American Association of Physicists in Medicine Recommendations of the American association of physicists in medicine on dosimetry, imaging, and quality assurance procedures for 90 Y microsphere brachytherapy in the treatment of hepatic malignancies.Med. Phys.20113884824484510.1118/1.360890921928655
     [Google Scholar]
  18. MartinM. HocqueletA. DebordeauxF. BordenaveL. BlancJ.F. PapadopoulosP. LapuyadeB. TrillaudH. PinaquyJ.B. Comparison of perfused volume segmentation between cone-beam CT and 99mTc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using 90Y-glass microspheres.Diagn. Interv. Imaging20211021455210.1016/j.diii.2020.09.00333032960
     [Google Scholar]
  19. CapalaJ. GravesS.A. ScottA. SgourosG. JamesS.S. ZanzonicoP. ZimmermanB.E. Dosimetry for radiopharmaceutical therapy: Current practices and commercial resources.J. Nucl. Med.202162Suppl. 33S11S10.2967/jnumed.121.26274934857621
     [Google Scholar]
  20. KnightG.M. GordonA.C. GatesV. TalwarA. RiazA. SalemR. LewandowskiR. Evolution of personalized dosimetry for radioembolization of Hepatocellular Carcinoma.J. Vasc. Interv. Radiol.20233471214122510.1016/j.jvir.2023.03.01136977431
     [Google Scholar]
  21. Riveira-MartinM AkhavanallafA MansouriZ Predictive value of 99mTc-MAA-based dosimetry in personalized 90Y-SIRT planning for liver malignancies.EJNMMI Res.20231316310.1186/s13550‑023‑01011‑3
     [Google Scholar]
  22. KaoY.H. SteinbergJ.D. TayY.S. LimG.K.Y. YanJ. TownsendD.W. BudgeonC.A. BoucekJ.A. FrancisR.J. CheoT.S.T. BurgmansM.C. IraniF.G. LoR.H.G. TayK.H. TanB.S. ChowP.K.H. SatchithananthamS. TanA.E.H. NgD.C.E. GohA.S.W. Post-radioembolization yttrium-90 PET/CT - part 2: Dose-response and tumor predictive dosimetry for resin microspheres.EJNMMI Res.2013315710.1186/2191‑219X‑3‑5723885971
     [Google Scholar]
  23. HasteP. TannM. PersohnS. LaRocheT. AaronV. MauxionT. ChauhanN. DreherM.R. JohnsonM.S. Correlation of technetium-99m macroaggregated albumin and yttrium-90 glass microsphere biodistribution in hepatocellular carcinoma: A retrospective review of pretreatment single photon emission CT and posttreatment positron emission tomography/CT.J. Vasc. Interv. Radiol.2017285722730.e110.1016/j.jvir.2016.12.122128238581
     [Google Scholar]
  24. Le FurM. CaravanP. 86Y PET imaging.Methods Enzymol.202165131334210.1016/bs.mie.2020.12.01333888208
     [Google Scholar]
  25. KnešaurekK. TuliA. KimE. HeibaS. KostakogluL. Comparison of PET/CT and PET/MR imaging and dosimetry of yttrium-90 (90Y) in patients with unresectable hepatic tumors who have received intra-arterial radioembolization therapy with 90Y microspheres.EJNMMI Phys.2018512310.1186/s40658‑018‑0222‑y30159638
     [Google Scholar]
/content/journals/crp/10.2174/0118744710333819250112153859
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The Estimation Value of 99mTc-MAA in Comparison with 90Y-PET/MR-based Dosimetry in Selective Internal Radiation Therapy (SIRT) for Liver Malignancies
Current Radiopharmaceuticals 18, 174 (2025); https://doi.org/10.2174/0118744710333819250112153859
/content/journals/crp/10.2174/0118744710333819250112153859
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  • Article Type:     Research Article
Keyword(s): 90Y; 99mTc-MAA; dosimetry; PET/MR; radioembolization; SPECT/CT

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