Current Psychiatry Research and Reviews - Volume 16, Issue 2, 2020

Introduction: There has long been a need for diagnostic, theragnostic, and prognostic biomarkers for psychiatric disorders. Biomarkers help in reducing ambiguity and arbitrariness and increase objectivity. In this context, many candidates for hormonal, immunological, serological, and neuroimaging markers have been proposed, but none of these marker candidates alone nor a biomarker panel has been approved for any disease. The fact that almost all psychiatric disorders are heterogeneous makes this process challenging. However, strong biomarker candidates have been identified, especially in light of the large number of clinical and preclinical studies conducted within the last five years. Objective: The aim of this article was to compile and discuss the current information on immune biomarkers in major psychiatric disorders, such as schizophrenia, depression, bipolar disorder, and anxiety disorders. Methods: In this study, respected scientific databases were searched using key terms related to the subject, and the related literature was examined in detail. Results: There are many relationships between psychiatric disorders and immune system parameters. Evidence also suggests that neuroinflammation is involved in the etiopathogenesis of psychiatric disorders. Markers, such as proinflammatory cytokines, tumor necrosis factor alpha, and C-reactive protein have been associated with psychiatric disorders in numerous studies. Conclusions: The neuroinflammation hypothesis has an important place in the etiopathogenesis of psychiatric disorders. Uncertainty remains as to whether neuroinflammation is a cause or consequence of psychiatric disorders. Some researchers have indicated that intestinal microbiota composition disorders and dysbiosis are sources of neuroinflammation. Immune marker studies are of great importance in terms of eliminating this uncertainty and overcoming diagnostic and treatment difficulties in the clinic. In this review, biomarker studies on psychiatric disorders were examined from the viewpoint of the immune system and discussed in light of the current studies.

Background: Epigenetic modifications appear to be dynamic and they might be affected by environmental factors. The possibility of influencing these processes through psychotherapy has been suggested. Objective: To analyse the impact of psychotherapy on epigenetics when applied to mental disorders. The main hypothesis is that psychological treatments will produce epigenetic modifications related to the improvement of treated symptoms. Methods: A computerised and systematic search was completed throughout the time period from 1990 to 2019 on the PubMed, ScienceDirect and Scopus databases. Results: In total, 11 studies were selected. The studies were evaluated for the theoretical framework, genes involved, type of psychotherapy and clinical challenges and perspectives. All studies showed detectable changes at the epigenetic level, like DNA methylation changes, associated with symptom improvement after psychotherapy. Conclusion: Methylation profiles could be moderating treatment effects of psychotherapy. Beyond the detected epigenetic changes after psychotherapy, the epigenetic status before the implementation could act as an effective predictor of response.

Background: Cognitive impairment as a consequence of stroke is a major cause affecting the patient’s functional independence, activity participation, daily living skills, and occupation. Almost 75% of post-stroke patients are diagnosed with significant cognitive impairment, which includes problems with attention, orientation, memory, language, and perception. Along with effective pharmaceutical cures, cognitive intervention as a part of rehabilitation approaches that may prevent, delay, or treat cognitive impairment is becoming increasingly important. Many studies have reported improvement in cognitive functions of post-stroke patients after using computer-based cognitive intervention (CBCI). CBCI can be an effective add-on to available rehabilitation programs. Objective: This article provides reviews related to relevant literature and, represents a structure to specify the efficacy of CBCI for the rehabilitation of post-stroke patients for future research. Methods: We searched many search engines namely MEDLINE, Web of Science, clinical key and The Cochrane Library, for studies investigating the effect of cognitive intervention based on a computer program for post-stroke patients. The results of selected studies were summarized. Total 19 publications from January 2007 to January 2019 are included in this review. The search terms entered were a combination of these search areas that defined (1) the population as adults who had suffered a stroke and cognitive dysfunction, (2) intervention search term included cognitive abilities, cognitive training, and computer-based training; computer-based cognitive intervention for rehabilitation. Results: The results after computer-based training showed improvement in various cognitive functions such as; memory, attention and executive functions of post-stroke patients. However, a significant difference between the study groups has not been observed in all the studies. Most studies analyzed in this research project indicated that such interventions might contribute to the improvement of cognitive function, especially attention concentration and memory. Of the 19 kinds of research that discussed CBCI outcomes 18 found significant improvements for one or more cognitive functions. When the effect size for CBCI was reported, effects were large in comparison to other traditional cognitive interventions of post-stroke patients. Conclusion: Studies related to cognitive functions strongly support CBCI except few have reported a significant difference. The review of all the studies suggests that CBCI may help to change the functional aspect of post-stroke patients by improving their cognitive functions. In this field, it is a challenge to conduct well designed and sufficiently powered studies due to low budgets availability, the limited number of available patients, heterogeneity of the population, and ethical considerations. Future studies should examine all the challenges, limitations, and valuable insights into the study and emphasize the need for a carefully designed computer-based cognitive intervention program for the future. Future studies should target to compare CBCI with active and passive control conditions and include a larger sample size.

Background: While comorbidity between mental disorders and physical illnesses is the rule rather than an exception, appraising the impact of comorbidity is challenging due to lack of consensus about how to define and measure the concept of comorbidity. Objective: The aim of the present evaluation was to appraise the prevalence and features of medical comorbidities among a group of native elderly schizophrenic patients. Methods: Geriatric unit of Razi psychiatric hospital was selected as the field of investigation and 168 elderly schizophrenic patients (≥65 years old), including 101 males and 67 females, who have been hospitalized there as chronic cases, were chosen as an accessible sample, and were surveyed with respect to existing comorbid medical disorders. Psychiatric diagnosis was based on ‘Diagnostic and Statistical Manual of Mental Disorders', 5th edition (DSM-5), and the medical diagnosis was based on ‘International Classification of Diseases’, 10th edition. Results: As shown by the results, 89% (n=151) of elderly schizophrenic patients had some kind of registered physical co-morbidity, which was more significant than the frequency of medical comorbidities among native senior citizens. Amongst the listed co-morbidities, falls, hypertension and osteoarthritis were the most prevalent comorbidities with a frequency of around 48.8%, 44.6% and 39.2%, respectively. Hypertension, renal disease and malnutrition were significantly more prevalent among male patients (p<0.0000, p<0.0045 and p< 0.0018, respectively) and hyponatremia, aspiration/ asphyxiation and seizure were meaningfully more prevalent among female patients (p<0.0075, p<0.0000 and p<0.0009, respectively). As stated by the findings and in comparison with the native seniors, while diabetes, renal diseases and malnutrition were significantly more frequent, coronary artery disease, gastrointestinal disorder and osteoarthritis were significantly less frequent in the existing sample of elderly schizophrenic patients. Conclusion: In comparison with the native senior people, the rate of medical comorbidities, particularly diabetes, renal diseases and malnutrition, was significantly higher in elderly schizophrenic patients, a significant difference, was observed regarding physical comorbidities between male and female patients, which demands further methodical and gender-based studies for defining more appropriate care.

Background: Epidemiologic studies have shown that persons suffering from psychotic disorders are at increased risk of violent behavior. Several factors have been shown to predict violent behavior among persons with psychosis. However, prior research is limited in that these factors have not been explored simultaneously within the same study. Methods: The current study, therefore, aimed to determine which demographic, clinical, cognitive, and developmental characteristics were associated with an increased likelihood of violence among patients diagnosed with a psychotic disorder and which combination of these best predicted a history of violence. Participants (n=53) completed measures of demographics, violence risk, psychotic and personality symptoms, trauma, psychopathy and cognitive functioning. Results: Bivariate relationships were conducted to compare the history of violent behavior between all variables. Additionally, a binary logistic regression was run predicting participants’ history of violence. Several demographic, cognitive, clinical, and developmental factors were associated with increased odds of having a history of violence. The overall correct classification rate for the model was 92.2%, with 87.5% of participants without a history of violence and 91.4% with a history of violence being correctly classified. The model included antisocial personality traits, poor behavioral controls, head injury, not accepting responsibility, lacking goals, prior supervision failures, and HCR-20 total score. Conclusion: The binary logistic regression model showed good accuracy in predicting a history of violence in persons with psychosis. These findings are consistent with prior research and can inform efforts at risk assessment and identification of treatment targets for people with a psychotic disorder who are at highest risk of violence.

Background: Cognitive impairment is one of the most common diseases in the elderly. Several studies have already been conducted to identify related factors, but few have explored all the factors involved in the development of cognitive problems. Objective: The present study aimed to identify significant biopsychosocial predictors of cognitive impairment. Methods: This case-control study was conducted on 535 elderly people referred to Shafa Clinic in the city of Tehran in 2017. The biological factors including serum cholesterol, fasting blood sugar, systolic and diastolic blood pressure, vitamin D, vitamin B12, serum folate, serum homocysteine, height, and weight were measured. The psychological variable in this study was a history of depression that was extracted from the medical records. Social network and social support were measured by LSNS-6 and MOS-SSS questionnaires. The SPSS version 25 was used to analyze the data. Results: The mean age of the control group was 68.4 years (SD = 5.89) and of the case group was 71.5 years (SD = 7.37). The results of multiple logistic regression analysis showed age (AOR=1.05; CI:1.089-1.016, p≤0.05,), Secondary education (AOR=0.51; CI:0.266-0.990, p<0.05,), Tertiary education (AOR=0.41; CI:0.212-0.810, p<0.01,), hypertension (AOR=2.16; CI:3.671-1.266, p<0.01) homocysteine level (AOR=1.09; CI:1.147-1.045, p<0.001,), Hypothyroidism (AOR=0.43; CI: 0.226 0.820, p<0.001,), and depression (AOR=4.5; CI:7.163-2.822, p<0.001) to be significant predictors of cognitive impairment. Conclusion: Results of this study showed that low education level, high blood pressure, high level of homocysteine and depression likely increase the risk of cognitive impairment; also, it was implied that timely screening can identify people at risk. The novelty of the present study is that it used a combination of the biopsychosocial factors to predict unique predictors of cognitive impairment.

Background: Many scholars believe that mental disorders may increase the risk of mortality among psychiatric patients in comparison with ordinary people. Unfortunately, since there is no systematic psychiatric case register system in Iran, a precise study of the rate of mortality of psychiatric patients in Iran is not easy. Objective: The objective of the current study included estimation of the rate of mortality and clinical profile of the died patients in a group of non-western aged schizophrenic patients. Methods: Senior section of Razi psychiatric hospital was selected as the specific field of investigation, and all elderly schizophrenic patients (≥65 years old), who had been hospitalized there, were nominated as the accessible sample and estimated with respect to the objectives of the present assessment. For survey, all deaths in the said district, which had occurred throughout the last sixty months (April of 2014-August 2019), had been listed by the supervisor of the mortality committee of the hospital. The clinical diagnosis was based on ‘Diagnostic and Statistical Manual of Mental Disorders', 5th edition, criteria. Results: Among 840 chronic elderly schizophrenic patients, 69 deaths were registered by the mortality committee of the hospital. As evident by the results, the annual rate of mortality among elderly schizophrenic patients in the present assessment was around 0.015 (0.15 per 1,000 individuals per year) and 0.017 (0.17 per 1,000 individuals per year) among male and female aged patients, respectively, which was significantly lower than the native crude death rate. While the average age of the expired female patients was significantly longer than male cases, the life expectancy of both male and female patients was significantly shorter than the life expectancy of native people. Besides, while among the present sample of old schizophrenics cardiac disease was the main leading cause of death, other causes, like violence, suicide, road traffic accidents, falls, fires, drug use, tuberculosis, drowning, epilepsy, and Parkinson’s disease were not liable at all. Conclusion: While the rate of mortality among aged schizophrenics was significantly lower than the native crude death rate, the age of the expired female patients was significantly longer than the male cases and the life expectancy of both male and female patients was significantly shorter than the life expectancy of native people. Cardiac disorder was the leading cause of death among the present sample of aged schizophrenics.

Background: Attention deficit hyperactivity disorder (ADHD) is the most common mental health disorder among young children that affects the mothers' lifestyles The aim of the present study was to consider the quality of life in Iranian mothers with ADHD children. Objective: In this comparative study, we compared the quality of life between mothers of ADHD children and mothers of normal children. Methods: In this descriptive study (2018-2019), a total of 75 mothers with ADHD children and 75 mothers with normal children, who were referred to referral educational hospital (Rasoul Hospital; Tehran, Iran) were evaluated. ADHD criteria were assessed by means of the SNAP-IV questionnaire, while the quality of life was evaluated by the SF-36 questionnaire. All data were analyzed by SPSS software. The environmental, mental, social physical, health and quality of life were compared between 2 groups. Results: The economic situation of mothers with normal children was average (73.3%) to good (16%), while in mothers with ADHD children the economic situation was average (45.3%) to poor (37.3%). Mothers' employment in normal children group was 41.3%, but it was 14.6% in mothers with ADHD children. A significant difference was reported between two groups in the mean of environmental health score (p <0.05), social relationships (p <0.05), mental health (p <0.05), physical health (p <0.01) and quality of life (p <0.01). The mean score of environmental health, social relationships, mental health, physical health and quality of life in ADHD mothers was significantly lower than mothers with normal children. Conclusion: The difficulties in the management of ADHD children negatively affect the quality of mothers' lifestyles. Therefore, preventive, educational and therapeutic interventions are recommended to improve the mental health and the quality of life of mothers.

Background: Responses to external emotional-stimuli or their transitions might help to elucidate the scientific background and assist the clinical management of psychiatric problems, but pure emotional-materials and their utilization at different levels of neurophysiological processing are few. Objective: We aimed to describe the responses at central and peripheral levels in healthy volunteers and psychiatric patients when facing external emotions and their transitions. Methods: Using pictures and sounds with pure emotions of Disgust, Erotica, Fear, Happiness, Neutral, and Sadness or their transitions as stimuli, we have developed a series of non-invasive techniques, i.e., the event-related potentials, functional magnetic resonance imaging, excitatory and inhibitory brainstem reflexes, and polygraph, to assess different levels of neurophysiological responses in different populations. Results: Sample outcomes on various conditions were specific and distinguishable at cortical to peripheral levels in bipolar I and II disorder patients compared to healthy volunteers. Conclusion: Methodologically, designs with these pure emotions and their transitions are applicable, and results per se are specifically interpretable in patients with emotion-related problems.