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2000
Volume 21, Issue 4
  • ISSN: 1573-3963
  • E-ISSN: 1875-6336

Abstract

Background

The COVID-19 global pandemic was caused by a novel coronavirus (SARS-CoV-2), which then became an endemic infection. COVID refers to the World Health Organization’s coined acronym for coronavirus disease.

Case Presentation

We have, herein, reported three cases of COVIDs that could have been misdiagnosed as COVID-19. All of these families reported previous COVID-19 infection based on self- administered Rapid Antigen Testing (RAT) and completed a period of home isolation. In these 3 cases, one child had an RSV-associated asthma attack, one had norovirus gastritis, and another had an infection with and . NL63, OC43, and 229E, respectively, were found by PCR in these patients.

Discussion

Seven human coronaviruses cause human infectious diseases. Confusion and issues associated with coronavirus disease diagnosis by Polymerase Chain Reaction (PCR) testing and Rapid Antigen Test (RAT) may arise. Some RATs are Antigen Fluorescent Immunoassays (FIA) that target monoclonal antibodies for the detection of viral nucleocapsid protein. Others target the non-nucleocapsid proteins. False positivity is possible. False negativity is also possible if the specimen’s antigen level is below the test's detection limit. RAT results usually remain positive for 6 to 7 days, but they may stay positive as long as 2 weeks. Stigmatization with the COVID-19 diagnosis may occur. The PCR test is a highly sensitive ‘gold standard’ for the detection of COVID-19, but it can also detect non-infectious individuals’ fragmented non-infectious viral nucleic acids, and could be positive for a long period. An individual may be tested positive for a few weeks to months after the individual becomes non-infectious.

Conclusion

The cases presented here had COVID other than COVID-19, caused by coronavirus variants other than SARS-CoV-2. Co-infections with other pathogens are present in these "Non- COVID-19" COVIDs. PCR testing of non-COVID-19 COVIDs may help in the accurate diagnosis of these ailments and respiratory co-infections.

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2024-05-20
2025-09-08

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References

  1. HonK.L. LeungK.K.Y. LeungA.K.C. SridharS. QianS. LeeS.L. ColinA.A. Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS.Pediatr. Pulmonol.20205571584159110.1002/ppul.2481032483934
     [Google Scholar]
  2. HonK.L. LeungK.K.Y. Severe acute respiratory symptoms and suspected SARS again 2020.Hong Kong Med. J.2020261787910.12809/hkmj20837532077866
     [Google Scholar]
  3. HonK.L. Proliferation of syndromes and acronyms in paediatric critical care: Are we more or less confused?Hong KongHong Kong Academy of Medicine Press20202610.12809/hkmj198059
     [Google Scholar]
  4. HonK.L. LeungK.K.Y. HuiW.F. NgD.K.K. Applying lessons from influenza pandemics to the COVID-19 pandemic.Pediatr. Pulmonol.20215693071307410.1002/ppul.2557134288587
     [Google Scholar]
  5. HonK.L. LeungK.K.Y. LeungA.K.C. QianS.Y. ChanV.P.Y. WongI.C.K. Coronavirus disease 2019 (COVID-19): Latest developments in potential treatments.Drugs Context2020911410.7573/dic.2020‑4‑1532655654
     [Google Scholar]
  6. LeungT.F. WongG.W.K. HonK.L.E. FokT.F. Severe acute respiratory syndrome (SARS) in children: Epidemiology, presentation and management.Paediatr. Respir. Rev.20034433433910.1016/S1526‑0542(03)00088‑514629957
     [Google Scholar]
  7. HonK.L.E. LeungC.W. ChengW.T.F. ChanP.K.S. ChuW.C.W. KwanY.W. LiA.M. FongN.C. NgP.C. ChiuM.C. LiC.K. TamJ.S. FokT.F. Clinical presentations and outcome of severe acute respiratory syndrome in children.Lancet200336193701701170310.1016/S0140‑6736(03)13364‑812767737
     [Google Scholar]
  8. HonK.L. LeungA.K. LeungK.K.Y. Impact of “Long Covid” on Children: Global and Hong Kong perspectives.Curr. Pediatr. Rev.20221910.2174/157339631966622102115494936281870
     [Google Scholar]
  9. HonK.L. LeungK.K.Y. Elimination, containment, and mitigation of COVID-19: A personal story about international travels.Curr. Pediatr. Rev.20221810.2174/157339631866622082315294236017828
     [Google Scholar]
  10. HonK.L.E. LiA.M. ChengF.W.T. LeungT.F. NgP.C. Personal view of SARS: Confusing definition, confusing diagnoses.Lancet200336193731984198510.1016/S0140‑6736(03)13556‑812801758
     [Google Scholar]
  11. HonK.L. LeungK.K.Y. COVID-19 tests and international travel: How long will you test positive for SAR-CoV-2.Curr. Respir. Med. Rev.20221810.2174/1573398X18666220920120531
     [Google Scholar]
  12. WangY. GrunewaldM. PerlmanS. Coronaviruses: An updated overview of their replication and pathogenesis.Methods Mol. Biol.2020220312910.1007/978‑1‑0716‑0900‑2_132833200
     [Google Scholar]
  13. FehrA.R. PerlmanS. Coronaviruses: An overview of their replication and pathogenesis.Methods Mol. Biol.2015128212310.1007/978‑1‑4939‑2438‑7_125720466
     [Google Scholar]
  14. PyrcK. BerkhoutB. van der HoekL. Identification of new human coronaviruses.Expert Rev. Anti Infect. Ther.20075224525310.1586/14787210.5.2.24517402839
     [Google Scholar]
  15. VanderH.L. JebbinM.F. WolthersK.C. Identification of a new human coronavirus.Nat. Med.20041036873
     [Google Scholar]
  16. LiuP. ShiL. ZhangW. HeJ. LiuC. ZhaoC. KongS.K. LooJ.F.C. GuD. HuL. Prevalence and genetic diversity analysis of human coronaviruses among cross-border children.Virol. J.201714123010.1186/s12985‑017‑0896‑029166910
     [Google Scholar]
  17. ForgieS. MarrieT. Healthcare-associated atypical pneumonia.Semin. Respir. Crit. Care Med.200930106708510.1055/s‑0028‑111981119199189
     [Google Scholar]
  18. PolverinoE. TorresA. Diagnostic strategies for healthcare-associated pneumonia.Semin. Respir. Crit. Care Med.200930103604510.1055/s‑0028‑111980719199185
     [Google Scholar]
  19. LauS.K.P. WooP.C.Y. YipC.C.Y. TseH. TsoiH. ChengV.C.C. LeeP. TangB.S.F. CheungC.H.Y. LeeR.A. SoL. LauY. ChanK. YuenK. Coronavirus HKU1 and other coronavirus infections in Hong Kong.J. Clin. Microbiol.20064462063207110.1128/JCM.02614‑0516757599
     [Google Scholar]
  20. LeungT.F. ChanP.K.S. Human coronavirus NL63 in children: Epidemiology, disease spectrum, and genetic diversity.Hong Kong Med J.201218Suppl 22730
     [Google Scholar]
  21. LeeJ. StorchG.A. Characterization of human coronavirus OC43 and human coronavirus NL63 infections among hospitalized children <5 years of age.Pediatr. Infect. Dis. J.201433881482010.1097/INF.000000000000029224577040
     [Google Scholar]
  22. SureK. UberlaK. IhorstG. StangK. Croup is associated with the novel coronavirus NL63.PLoS Med.200528e24010.1371/journal.pmed.0020240
     [Google Scholar]
  23. SureK. UberlaK. IhorstG. PyrcK. Human coronavirus NL63 infection is associated with croup. 2006;581:485–91Adv. Exp. Med. Biol.20065814859110.1007/978‑0‑387‑33012‑9_86
     [Google Scholar]
  24. LeungK.K.Y. ChuS.P.W. HonK.L. LeungT.F. Indirect consequences of COVID-19 on children’s health.Hong Kong Med. J.202127216010.12809/hkmj20869433843610
     [Google Scholar]
  25. LeungK.K.Y. HonK.L. Paediatric multisystem inflammatory syndrome and COVID-19: Another novel syndrome?Hong Kong Med. J.2021272161210.12809/hkmj208681
     [Google Scholar]
  26. RoutsiasJ.G. MavrouliM. TsoplouP. DioikitopoulouK. TsakrisA. Diagnostic performance of rapid antigen tests (RATs) for SARS-CoV-2 and their efficacy in monitoring the infectiousness of COVID-19 patients.Sci. Rep.20211112286310.1038/s41598‑021‑02197‑z34819567
     [Google Scholar]
  27. GhasemiS. HarmooshiN.N. RahimF. Diagnostic utility of antigen detection rapid diagnostic tests for Covid-19: A systematic review and meta-analysis.Diagn. Pathol.20221713610.1186/s13000‑022‑01215‑635414002
     [Google Scholar]
  28. MinaM.J. PetoT.E. García-FiñanaM. SempleM.G. Buchani.e. Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19.Lancet2021397102831425142710.1016/S0140‑6736(21)00425‑633609444
     [Google Scholar]
  29. CattelanA.M. SassetL. ZabeoF. FerrariA. RossiL. MazzitelliM. CocchioS. BaldoV. Rapid Antigen Test LumiraDxTM vs. Real Time Polymerase Chain Reaction for the Diagnosis of SARS-CoV-2 Infection: A retrospective cohort study.Int. J. Environ. Res. Public Health2022197382610.3390/ijerph1907382635409513
     [Google Scholar]
  30. BollingerM. Saile P. ShapetonA.D. Sensitivity of severe acute respiratory syndrome coronavirus type 2 rapid antigen point-of-care tests in vaccinated patients.Eur. J Emerg Med.2022294285290
     [Google Scholar]
  31. EUROPEAN UNIONList of mutually recognised COVID-19 laboratory based antigenic assays (Annex III).2023
  32. WölfelR. CormanV.M. GuggemosW. SeilmaierM. ZangeS. MüllerM.A. NiemeyerD. JonesT.C. VollmarP. RotheC. HoelscherM. BleickerT. BrüninkS. SchneiderJ. EhmannR. ZwirglmaierK. DrostenC. WendtnerC. Virological assessment of hospitalized patients with COVID-2019.Nature2020581780946546910.1038/s41586‑020‑2196‑x32235945
     [Google Scholar]
  33. ZouL. RuanF. HuangM. LiangL. HuangH. HongZ. YuJ. KangM. SongY. XiaJ. GuoQ. SongT. HeJ. YenH.L. PeirisM. WuJ. SARS-CoV-2 viral load in upper respiratory specimens of infected patients.N. Engl. J. Med.2020382121177117910.1056/NEJMc200173732074444
     [Google Scholar]
  34. YoungB.E. OngS.W.X. KalimuddinS. LowJ.G. TanS.Y. LohJ. NgO.T. MarimuthuK. AngL.W. MakT.M. LauS.K. AndersonD.E. ChanK.S. TanT.Y. NgT.Y. CuiL. SaidZ. KurupathamL. ChenM.I.C. ChanM. VasooS. WangL.F. TanB.H. LinR.T.P. LeeV.J.M. LeoY.S. LyeD.C. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.JAMA2020323151488149410.1001/jama.2020.320432125362
     [Google Scholar]
  35. KujawskiS.A. WongK.K. CollinsJ.P. EpsteinL. KillerbyM.E. MidgleyC.M. Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States.Nat. Med.202026686186810.1038/s41591‑020‑0877‑532327757
     [Google Scholar]
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  • Article Type:     Case Report
Keyword(s): 229E, HKU1; coronavirus disease; COVID-19; NL63; OC43; SARS-CoV; SARS-CoV-2

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