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2000
Volume 26, Issue 5
  • ISSN: 1389-2037
  • E-ISSN: 1875-5550

Abstract

The diagnosis of intestinal injury remains a challenge as it is rare in occurrence and transpires in multiple traumatized patients. The deferred finding of injury of intestines upsurges multiple risks such as septicemia, numerous organ failures as well as mortality. In this review, we corroborate with the goals of proposing surrogate biomarkers that consent to the measurement of the permeability of intestines more effortlessly. The expression of intestinal fatty acid binding protein (I-FABP) is exclusive in the intestine and has been reported to release extracellularly upon damage caused to tissues. This work focuses on evaluating the legitimacy of I-FABP as an initial biomarker to distinguish abdominal damage predominantly from an injury to the intestine.

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2025-01-01
2025-09-04

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References

  1. KaikausR.M. BassN.M. OcknerR.K. Functions of fatty acid binding proteins.Experientia199046661763010.1007/BF019397012193826
     [Google Scholar]
  2. AgakidouE. AgakidisC. GikaH. SarafidisK. Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics.Front. Pediatr.2020860225510.3389/fped.2020.60225533425815
     [Google Scholar]
  3. AlhadiH.A. FoxK.A.A. Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein.QJM200497418719810.1093/qjmed/hch03715028848
     [Google Scholar]
  4. WangD. ZhaoL. LiaoZ. BiQ. MengX. DuanM. MaQ. WeiY. CaoL. LiangM. XuH. Tissue distribution and nutritional regulation of fatty acid-binding proteins (fabps) in two marine teleosts, turbot (Scophthalmus maximus), and tiger puffer (Takifugu rubripes).Aquacult. Nutr.20222022111410.1155/2022/8761851
     [Google Scholar]
  5. KayserH. 4.8 - Lipocalins and structurally related ligand-binding proteins.Comprehensive Molecular Insect Science. GilbertL.I. AmsterdamElsevier200526730610.1016/B0‑44‑451924‑6/00056‑9
     [Google Scholar]
  6. XuB. ChenL. ZhanY. MarquezK.N.S. ZhuoL. QiS. ZhuJ. HeY. ChenX. ZhangH. ShenY. ChenG. GuJ. GuoY. LiuS. XieT. The biological functions and regulatory mechanisms of fatty acid binding protein 5 in various diseases.Front. Cell Dev. Biol.20221085791910.3389/fcell.2022.85791935445019
     [Google Scholar]
  7. GaffarS. AathirahA.S. Fatty-acid-binding proteins: From lipid transporters to disease biomarkers.Biomolecules20231312175310.3390/biom1312175338136624
     [Google Scholar]
  8. Vogel HertzelA. BernlohrD.A. The mammalian fatty acid-binding protein multigene family: Molecular and genetic insights into function.Trends Endocrinol. Metab.200011517518010.1016/S1043‑2760(00)00257‑510856918
     [Google Scholar]
  9. HotamisligilG.S. BernlohrD.A. Metabolic functions of FABPs—mechanisms and therapeutic implications.Nat. Rev. Endocrinol.2015111059260510.1038/nrendo.2015.12226260145
     [Google Scholar]
  10. SmathersR.L. PetersenD.R. The human fatty acid-binding protein family: Evolutionary divergences and functions.Hum. Genomics20115317019110.1186/1479‑7364‑5‑3‑17021504868
     [Google Scholar]
  11. ChmurzyńskaA. The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphism.J. Appl. Genet.2006471394810.1007/BF0319459716424607
     [Google Scholar]
  12. StorchJ. ThumserA.E. Tissue-specific functions in the fatty acid-binding protein family.J. Biol. Chem.201028543326793268310.1074/jbc.R110.13521020716527
     [Google Scholar]
  13. GajdaA.M. StorchJ. Enterocyte fatty acid-binding proteins (FABPs): Different functions of liver and intestinal FABPs in the intestine.Prostaglandins Leukot. Essent. Fatty Acids20159391610.1016/j.plefa.2014.10.00125458898
     [Google Scholar]
  14. FABP2 fatty acid binding protein 2.2024Available from: https://www.ncbi.nlm.nih.gov/gene/2169
  15. LariflaL. RambhojanC. JoannesM.O. Maimaitiming-MadaniS. DonnetJ.P. Marianne-PépinT. ChoutR. RousselR. FoucanL. Gene Polymorphisms of FABP2, ADIPOQ and ANP and risk of hypertriglyceridemia and metabolic syndrome in afro-caribbeans.PLoS One2016119e016342110.1371/journal.pone.016342127684940
     [Google Scholar]
  16. FunaokaH. KandaT. FujiiH. Intestinal fatty acid-binding protein (I-FABP) as a new biomarker for intestinal diseases.Jpn. J. Clin. Pathol.2010582162168
     [Google Scholar]
  17. VothM. LustenbergerT. ReljaB. MarziI. Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?World J. Emerg. Surg.20191414910.1186/s13017‑019‑0267‑931832083
     [Google Scholar]
  18. de GrootM. WodzigK.W. SimoonsM.L. GlatzJ.F. HermensW.T. Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglobin, using individually estimated clearance rates.Cardiovasc. Res.199944231532410.1016/S0008‑6363(99)00199‑610690308
     [Google Scholar]
  19. PelsersM.M.A.L. NamiotZ. KisielewskiW. NamiotA. JanuszkiewiczM. HermensW.T. GlatzJ.F.C. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility.Clin. Biochem.200336752953510.1016/S0009‑9120(03)00096‑114563446
     [Google Scholar]
  20. QiuC.J. YeX.Z. YuX.J. PengX.R. LiT.H. Association between FABP 2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: A huge review and meta-analysis.J. Cell. Mol. Med.201418122530253510.1111/jcmm.1238525388378
     [Google Scholar]
  21. AgellonL.B. Importance of fatty acid binding proteins in cellular function and organismal metabolism.J. Cell. Mol. Med.2024285e1770310.1111/jcmm.1770336876733
     [Google Scholar]
  22. HuangX. ZhouY. SunY. WangQ. Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism.Prog. Lipid Res.20228710117810.1016/j.plipres.2022.10117835780915
     [Google Scholar]
  23. AuingerA. HelwigU. RubinD. HerrmannJ. JahreisG. PfeufferM. de VreseM. FoelschU.R. SchreiberS. DoeringF. SchrezenmeirJ. Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms.J. Nutr.201014081411141710.3945/jn.109.11803420534879
     [Google Scholar]
  24. LauE. MarquesC. PestanaD. SantoalhaM. CarvalhoD. FreitasP. CalhauC. The role of I-FABP as a biomarker of intestinal barrier dysfunction driven by gut microbiota changes in obesity.Nutr. Metab.20161313110.1186/s12986‑016‑0089‑727134637
     [Google Scholar]
  25. BaierL.J. SacchettiniJ.C. KnowlerW.C. EadsJ. PaolissoG. TataranniP.A. MochizukiH. BennettP.H. BogardusC. ProchazkaM. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.J. Clin. Invest.19959531281128710.1172/JCI1177787883976
     [Google Scholar]
  26. FuruhashiM. HotamisligilG.S. Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets.Nat. Rev. Drug Discov.20087648950310.1038/nrd258918511927
     [Google Scholar]
  27. StorchJ. CorsicoB. The multifunctional family of mammalian fatty acid–binding proteins.Annu. Rev. Nutr.2023431255410.1146/annurev‑nutr‑062220‑11224037207357
     [Google Scholar]
  28. KokesovaA. CoufalS. FrybovaB. KverkaM. RyglM. The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis.PLoS One2019141e021079710.1371/journal.pone.021079730640955
     [Google Scholar]
  29. PouliS. KozanaA. PapakitsouI. DaskalogiannakiM. RaissakiM. Gastrointestinal perforation: Clinical and MDCT clues for identification of aetiology.Insights Imaging20201113110.1186/s13244‑019‑0823‑632086627
     [Google Scholar]
  30. YangY. Oral drug absorption: Evaluation and prediction.Developing Solid Oral Dosage Forms.2nd ed QiuY. BostonAcademic Press201733135410.1016/B978‑0‑12‑802447‑8.00012‑1
     [Google Scholar]
  31. VancamelbekeM. VermeireS. The intestinal barrier: A fundamental role in health and disease.Expert Rev. Gastroenterol. Hepatol.201711982183410.1080/17474124.2017.134314328650209
     [Google Scholar]
  32. SubramanianS. GengH. TanX.D. Cell death of intestinal epithelial cells in intestinal diseases.Sheng Li Xue Bao202072330832432572429
     [Google Scholar]
  33. MohanKumarK. KillingsworthC.R. Britt McILwainR. TimpaJ.G. JagadeeswaranR. NamachivayamK. KurundkarA.R. KellyD.R. GarzonS.A. MaheshwariA. Intestinal epithelial apoptosis initiates gut mucosal injury during extracorporeal membrane oxygenation in the newborn piglet.Lab. Invest.201494215016010.1038/labinvest.2013.14924365747
     [Google Scholar]
  34. LangellJ.T. MulvihillS.J. Gastrointestinal perforation and the acute abdomen.Med. Clin. North Am.2008923599625, viii-ix10.1016/j.mcna.2007.12.00418387378
     [Google Scholar]
  35. GrootjansJ. ThuijlsG. VerdamF. DerikxJ.P. LenaertsK. BuurmanW.A. Non-invasive assessment of barrier integrity and function of the human gut.World J. Gastrointest. Surg.201023616910.4240/wjgs.v2.i3.6121160852
     [Google Scholar]
  36. HafnerJ. Intestinal perforation.StatPearlsStatPearls PublishingTreasure Island (FL)2022
     [Google Scholar]
  37. BlackC.J. DrossmanD.A. TalleyN.J. RuddyJ. FordA.C. Functional gastrointestinal disorders: Advances in understanding and management.Lancet2020396102631664167410.1016/S0140‑6736(20)32115‑233049221
     [Google Scholar]
  38. FordA.C. MahadevaS. CarboneM.F. LacyB.E. TalleyN.J. Functional dyspepsia.Lancet2020396102631689170210.1016/S0140‑6736(20)30469‑433049222
     [Google Scholar]
  39. FoxM.R. KahrilasP.J. RomanS. GyawaliC.P. ScottS.M. RaoS.S. KellerJ. CamilleriM. International Working Group for Disorders of Gastrointestinal Motility and Function Clinical measurement of gastrointestinal motility and function: Who, when and which test?Nat. Rev. Gastroenterol. Hepatol.201815956857910.1038/s41575‑018‑0030‑929872118
     [Google Scholar]
  40. DuPontH.L. Acute infectious diarrhea in immunocompetent adults.N. Engl. J. Med.2014370161532154010.1056/NEJMra130106924738670
     [Google Scholar]
  41. AndersenL.W. LandowL. BaekL. JansenE. BakerS. Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and tumor necrosis factor-α concentrations in patients undergoing cardiopulmonary bypass.Crit. Care Med.199321221021710.1097/00003246‑199302000‑000118428471
     [Google Scholar]
  42. GollinG. MarksC. MarksW.H. Intestinal fatty acid binding protein in serum and urine reflects early ischemic injury to the small bowel.Surgery199311355455518488474
     [Google Scholar]
  43. SikoraM. StecA. ChrabaszczM. Waskiel-BurnatA. ZarembaM. OlszewskaM. RudnickaL. Intestinal fatty acid binding protein, a biomarker of intestinal barrier, is associated with severity of psoriasis.J. Clin. Med.201987102110.3390/jcm807102131336842
     [Google Scholar]
  44. UzunO. TurkmenS. EryigitU. MenteseA. TurkyilmazS. TurediS. KarahanS.C. GunduzA. Can intestinal fatty acid binding protein (I-FABP) be a marker in the diagnosis of abdominal pathology?Turk. J. Emerg. Med.20141439910310.5505/1304.7361.2014.1567927355087
     [Google Scholar]
  45. WangY. DingL. YangJ. LiuL. DongL. Intestinal fatty acid-binding protein, a biomarker of intestinal barrier dysfunction, increases with the progression of type 2 diabetes.PeerJ20219e1080010.7717/peerj.1080033604184
     [Google Scholar]
  46. VollrathJ.T. KlingebielF. BläsiusF. GrevenJ. BolierakisE. NowakA.J. SimicM. HildebrandF. MarziI. ReljaB. I- FABP as a potential marker for intestinal barrier loss in porcine polytrauma.J. Clin. Med.20221115459910.3390/jcm1115459935956214
     [Google Scholar]
  47. KandaT. TsukaharaA. UekiK. SakaiY. TaniT. NishimuraA. YamazakiT. TamiyaY. TadaT. HirotaM. HasegawaJ. FunaokaH. FujiiH. HatakeyamaK. Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen: A multicenter, observer-blinded validation study.J. Gastroenterol.201146449250010.1007/s00535‑011‑0373‑221298292
     [Google Scholar]
  48. AzerS.A. Intestinal Perforation.Emedicine2006April12
     [Google Scholar]
  49. HorowitzJ. KukoraJ.S. RitchieW.P., Jr. All perforated ulcers are not alike.Ann. Surg.1989209669369710.1097/00000658‑198906000‑000062730181
     [Google Scholar]
  50. AdriaanseM.P.M. TackG.J. PassosV.L. DamoiseauxJ.G.M.C. SchreursM.W.J. van WijckK. RiedlR.G. MascleeA.A.M. BuurmanW.A. MulderC.J.J. VreugdenhilA.C.E. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies.Aliment. Pharmacol. Ther.201337448249010.1111/apt.1219423289539
     [Google Scholar]
  51. GandiniA. De MaayerT. MunienC. BertrandK. CairnsR. MayneA. GededzhaM.P. MayneE.S. Intestinal fatty acid binding protein (I-FABP) and CXC3L1 evaluation as biomarkers for patients at high-risk for coeliac disease in Johannesburg, South Africa.Cytokine202215715594510.1016/j.cyto.2022.15594535841826
     [Google Scholar]
  52. SarikayaM. ErgülB. DoğanZ. FilikL. CanM. ArslanL. Intestinal fatty acid binding protein (I-FABP) as a promising test for Crohn’s disease: A preliminary study.Clin. Lab.20156101+02/2015879110.7754/Clin.Lab.2014.14051825807642
     [Google Scholar]
  53. LoganM. MacKinderM. ClarkC.M. KountouriA. JereM. IjazU.Z. HansenR. McGroganP. RussellR.K. GerasimidisK. Intestinal fatty acid binding protein is a disease biomarker in paediatric coeliac disease and Crohn’s disease.BMC Gastroenterol.202222126010.1186/s12876‑022‑02334‑635606704
     [Google Scholar]
  54. SunD.L. CenY.Y. LiS.M. LiW.M. LuQ.P. XuP.Y. Accuracy of the serum intestinal fatty-acid-binding protein for diagnosis of acute intestinal ischemia: A meta-analysis.Sci. Rep.2016613437110.1038/srep3437127681959
     [Google Scholar]
  55. ShaabanA.I.E. AlfqyO.A.E. ShaabanH.M.K. A-MaqsoudY.H. AssarE.H. Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates.J. Indian Assoc. Pediatr. Surg.202126639340010.4103/jiaps.JIAPS_218_2034912135
     [Google Scholar]
  56. YangG. WangY. JiangX. Diagnostic value of intestinal fatty-acid-binding protein in necrotizing enterocolitis: A systematic review and meta-analysis.Indian J. Pediatr.20168312-131410141910.1007/s12098‑016‑2144‑927272048
     [Google Scholar]
  57. DragoniG. InnocentiT. GalliA. Biomarkers of inflammation in inflammatory bowel disease: how long before abandoning single-marker approaches?Dig. Dis.202139319020310.1159/00051164132942275
     [Google Scholar]
  58. SeethalerB. BasraiM. NeyrinckA.M. NazareJ.A. WalterJ. DelzenneN.M. BischoffS.C. Biomarkers for assessment of intestinal permeability in clinical practice.Am. J. Physiol. Gastrointest. Liver Physiol.20213211G11G1710.1152/ajpgi.00113.202134009040
     [Google Scholar]
  59. YaoY.M. YuY. WuY. LuL.R. ShengZ.Y. Plasma D (-)-lactate as a new marker for diagnosis of acute intestinal injury following ischemia-reperfusion.World J. Gastroenterol.19973422522710.3748/wjg.v3.i4.22527053870
     [Google Scholar]
  60. VothM. DucheneM. AunerB. LustenbergerT. ReljaB. MarziI. I-FABP is a novel marker for the detection of intestinal injury in severely injured trauma patients.World J. Surg.201741123120312710.1007/s00268‑017‑4124‑228721572
     [Google Scholar]
  61. KhadarooR.G. FortisS. SalimS.Y. StreutkerC. ChurchillT.A. ZhangH. I-FABP as biomarker for the early diagnosis of acute mesenteric ischemia and resultant lung injury.PLoS One2014912e11524210.1371/journal.pone.011524225541714
     [Google Scholar]
  62. WuC. ZhuX. RenH. TanF. LiuX. Intestinal fatty acid-binding protein as a biomarker for the diagnosis of strangulated intestinal obstruction: A meta-analysis.Open Med.202116126427310.1515/med‑2021‑021433623822
     [Google Scholar]
  63. YeniocakS. SaraçF. YazıcıoğluM. KarabulutN. ÜnalA. YücetaşE. KoldaşM. Akkoçİ. EkiciM. EvrinT. The diagnostic values of ischemia-modified albumin in patients with acute abdominal pain and its role in differentiating acute abdomen.Emerg. Med. Int.202020201710.1155/2020/792597532509350
     [Google Scholar]
  64. KhuranaS. CorballyM.T. ManningF. ArmeniseT. KierceB. KiltyC. Glutathione S-transferase: A potential new marker of intestinal ischemia.J. Pediatr. Surg.200237111543154810.1053/jpsu.2002.3618112407536
     [Google Scholar]
  65. MaricS. RestinT. MuffJ. CamargoS. GuglielmettiL. Holland-CunzS. CrennP. Vuille-dit-BilleR. Citrulline, biomarker of enterocyte functional mass and dietary supplement. Metabolism, transport, and current evidence for clinical use.Nutrients2021138279410.3390/nu1308279434444954
     [Google Scholar]
  66. KartaramS. MensinkM. TeunisM. SchoenE. WitteG. Janssen DuijghuijsenL. VerschurenM. MohrmannK. M’RabetL. KnippingK. WittinkH. van HelvoortA. GarssenJ. WitkampR. PietersR. van NorrenK. Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men.Clin. Nutr.20193852251225810.1016/j.clnu.2018.09.02930340895
     [Google Scholar]
  67. SchellekensD.H.S.M. ReisingerK.W. LenaertsK. HadfouneM. Olde DaminkS.W. BuurmanW.A. DejongC.H.C. DerikxJ.P.M. SM22 a plasma biomarker for human transmural intestinal ischemia.Ann. Surg.2018268112012610.1097/SLA.000000000000227828525410
     [Google Scholar]
  68. MontagnanaM. DaneseE. LippiG. Biochemical markers of acute intestinal ischemia: Possibilities and limitations.Ann. Transl. Med.201861734110.21037/atm.2018.07.2230306080
     [Google Scholar]
  69. RuscelliP. RenziC. PolistenaA. SanguinettiA. AveniaN. PopivanovG. CirocchiR. LanciaM. GioiaS. TabolaR. Clinical signs of retroperitoneal abscess from colonic perforation.Medicine20189745e1317610.1097/MD.000000000001317630407351
     [Google Scholar]
  70. JonesM.W. KashyapS. ZabboC.P. Bowel Perforation.Treasure Island, FLStatPearls Publishing2021
     [Google Scholar]
  71. WhitehouseJ.S. WeigeltJ.A. Diagnostic peritoneal lavage: A review of indications, technique, and interpretation.Scand. J. Trauma Resusc. Emerg. Med.20091711310.1186/1757‑7241‑17‑1319267941
     [Google Scholar]
  72. KittakaH. AkimotoH. TakeshitaH. FunaokaH. HazuiH. OkamotoM. KobataH. OhishiY. Usefulness of intestinal fatty acid-binding protein in predicting strangulated small bowel obstruction.PLoS One201496e9991510.1371/journal.pone.009991524926782
     [Google Scholar]
  73. NorouziniaM. ChaleshiV. AlizadehA.H.M. ZaliM.R. Biomarkers in inflammatory bowel diseases: Insight into diagnosis, prognosis and treatment.Gastroenterol. Hepatol. Bed Bench201710315516729118930
     [Google Scholar]
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Insight of Intestinal Fatty Acid Binding Protein as a Potential Biomarker in the Biology of Epithelial Damage of Gastrointestinal Membrane
Curr. Protein Pept. Sci. 26, 321 (2025); https://doi.org/10.2174/0113892037311290240930054913
/content/journals/cpps/10.2174/0113892037311290240930054913
/content/journals/cpps/10.2174/0113892037311290240930054913
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  • Article Type:     Review Article
Keyword(s): epithelial injury; I-FABP; intestinal membrane; mortality; protein biomarker; septicemia

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