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2000
Volume 32, Issue 13
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder affecting both children and adults, characterized by intense itching, erythema, and xerosis. The pathogenesis of AD is multifactorial, involving genetic predisposition, immune dysregulation, skin barrier dysfunction, and environmental factors. A growing body of evidence suggests that oxidative stress plays a critical role in AD, contributing to chronic inflammation, immune cell activation, and skin barrier disruption. Oxidative stress arises from an imbalance between Reactive Oxygen Species (ROS) production and antioxidant defenses, leading to cellular damage and the exacerbation of AD symptoms. Recent research has highlighted the potential of plant-derived bioactive compounds, particularly those with antioxidant properties, to mitigate oxidative stress and provide therapeutic benefits in AD. These compounds, including quercetin, resveratrol, curcumin, silymarin, baicalin, luteolin, and epigallocatechin gallate, not only neutralize ROS but also exhibit anti-inflammatory, immunomodulatory, and skin barrier-restoring effects. Natural antioxidants from plants offer a safer alternative to conventional treatments, which may have long-term side effects. This review provides a comprehensive overview of the mechanisms by which oxidative stress contributes to AD and examines the potential of plant-derived antioxidants in alleviating AD symptoms. The growing interest in these compounds underscores the need for further research to harness their full therapeutic potential in AD management.

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2026-02-27

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References

  1. TianJ. ZhangD. YangY. HuangY. WangL. YaoX. LuQ. Global epidemiology of atopic dermatitis: A comprehensive systematic analysis and modelling study.Br. J. Dermatol.20231901556110.1093/bjd/ljad33937705227
     [Google Scholar]
  2. KimJ. KimB.E. LeungD.Y.M. Pathophysiology of atopic dermatitis: Clinical implications.Allergy Asthma Proc.2019402849210.2500/aap.2019.40.420230819278
     [Google Scholar]
  3. YangG. SeokJ.K. KangH.C. ChoY.Y. LeeH.S. LeeJ.Y. Skin barrier abnormalities and immune dysfunction in atopic dermatitis.Int. J. Mol. Sci.2020218286710.3390/ijms2108286732326002
     [Google Scholar]
  4. PizzinoG. IrreraN. CucinottaM. PallioG. ManninoF. ArcoraciV. SquadritoF. AltavillaD. BittoA. Oxidative stress: Harms and benefits for human health.Oxid. Med. Cell. Longev.201720171841676310.1155/2017/841676328819546
     [Google Scholar]
  5. Md JaffriJ. Reactive oxygen species and antioxidant system in selected skin disorders.Malays. J. Med. Sci.202330172010.21315/mjms2023.30.1.236875194
     [Google Scholar]
  6. TengY. ZhongH. YangX. TaoX. FanY. Current and emerging therapies for atopic dermatitis in the elderly.Clin. Interv. Aging2023181641165210.2147/CIA.S42604437810952
     [Google Scholar]
  7. MegnaM. NapolitanoM. PatrunoC. VillaniA. BalatoA. MonfrecolaG. AyalaF. BalatoN. Systemic treatment of adult atopic dermatitis: A review.Dermatol. Ther.20177112310.1007/s13555‑016‑0170‑128025775
     [Google Scholar]
  8. FormanH.J. ZhangH. Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy.Nat. Rev. Drug Discov.202120968970910.1038/s41573‑021‑00233‑134194012
     [Google Scholar]
  9. ShoaibS. AnsariM.A. FateaseA.A. SafhiA.Y. HaniU. JahanR. AlomaryM.N. AnsariM.N. AhmedN. WahabS. AhmadW. YusufN. IslamN. Plant-derived bioactive compounds in the management of neurodegenerative disorders: Challenges, future directions and molecular mechanisms involved in neuroprotection.Pharmaceutics202315374910.3390/pharmaceutics1503074936986610
     [Google Scholar]
  10. HebertA.A. Oxidative stress as a treatment target in atopic dermatitis: The role of furfuryl palmitate in mild-to-moderate atopic dermatitis.Int. J. Womens Dermatol.20206433133310.1016/j.ijwd.2020.03.04233015298
     [Google Scholar]
  11. PapaccioF. D ArinoA. CaputoS. BelleiB. Focus on the contribution of oxidative stress in skin aging.Antioxidants2022116112110.3390/antiox1106112135740018
     [Google Scholar]
  12. Chettouh-HammasN. FasaniF. BoileauA. GossetD. BuscoG. GrillonC. Improvement of antioxidant defences in keratinocytes grown in physioxia: Comparison of 2D and 3D models.Oxid. Med. Cell. Longev.2023202311510.1155/2023/682993137360501
     [Google Scholar]
  13. AlessandrelloC. SanfilippoS. MinciulloP.L. GangemiS. An overview on atopic dermatitis, oxidative stress, and psychological stress: Possible role of nutraceuticals as an additional therapeutic strategy.Int. J. Mol. Sci.2024259502010.3390/ijms2509502038732239
     [Google Scholar]
  14. van SmedenJ. BouwstraJ.A. Stratum corneum lipids: Their role for the skin barrier function in healthy subjects and atopic dermatitis patients.Curr. Probl. Dermatol.20164982610.1159/00044154026844894
     [Google Scholar]
  15. FurueM. Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic implications in atopic dermatitis.Int. J. Mol. Sci.20202115538210.3390/ijms2115538232751111
     [Google Scholar]
  16. AfzalS. Abdul ManapA.S. AttiqA. AlbokhadaimI. KandeelM. AlhojailyS.M. From imbalance to impairment: The central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration.Front. Pharmacol.202314126958110.3389/fphar.2023.126958137927596
     [Google Scholar]
  17. RaimondoA. SerioB. LemboS. Oxidative stress in atopic dermatitis and possible biomarkers: Present and future.Indian J. Dermatol.202368665766010.4103/ijd.ijd_878_2238371532
     [Google Scholar]
  18. KwonY.J. KwonH.H. LeemJ. JangY.Y. Kahweol inhibits pro-inflammatory cytokines and chemokines in tumor necrosis factor-α/interferon-γ-stimulated human keratinocyte hacat cells.Curr. Issues Mol. Biol.20244643470348310.3390/cimb4604021838666948
     [Google Scholar]
  19. LiuT. ZhangL. JooD. SunS.C. NF-κB signaling in inflammation.Signal Transduct. Target. Ther.2017211702310.1038/sigtrans.2017.2329158945
     [Google Scholar]
  20. GuoQ. JinY. ChenX. YeX. ShenX. LinM. ZengC. ZhouT. ZhangJ. NF-κB in biology and targeted therapy: New insights and translational implications.Signal Transduct. Target. Ther.2024915310.1038/s41392‑024‑01757‑938433280
     [Google Scholar]
  21. ShankarA. McAleesJ.W. LewkowichI.P. Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease.J. Allergy Clin. Immunol.2022150226627610.1016/j.jaci.2022.06.01235934680
     [Google Scholar]
  22. RomagnaniS. Cytokines and chemoattractants in allergic inflammation.Mol. Immunol.20023812-1388188510.1016/S0161‑5890(02)00013‑512009564
     [Google Scholar]
  23. WilliamsM.A. RangasamyT. BauerS.M. KilledarS. KarpM. KenslerT.W. YamamotoM. BreysseP. BiswalS. GeorasS.N. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter.J. Immunol.200818174545455910.4049/jimmunol.181.7.454518802057
     [Google Scholar]
  24. KangC. LiX. LiuP. LiuY. NiuY. ZengX. ZhaoH. LiuJ. QiuS. Tolerogenic dendritic cells and TLR4/IRAK4/NF-κB signaling pathway in allergic rhinitis.Front. Immunol.202314127651210.3389/fimmu.2023.127651237915574
     [Google Scholar]
  25. ShuP. LiangH. ZhangJ. LinY. ChenW. ZhangD. Reactive oxygen species formation and its effect on CD4+ T cell-mediated inflammation.Front. Immunol.202314119923310.3389/fimmu.2023.119923337304262
     [Google Scholar]
  26. AndradeB. Jara-GutiérrezC. Paz-AraosM. VázquezM.C. DíazP. MurgasP. The relationship between reactive oxygen species and the CGAS/STING signaling pathway in the inflammaging process.Int. J. Mol. Sci.202223231518210.3390/ijms23231518236499506
     [Google Scholar]
  27. MittalM. SiddiquiM.R. TranK. ReddyS.P. MalikA.B. Reactive oxygen species in inflammation and tissue injury.Antioxid. Redox Signal.20142071126116710.1089/ars.2012.514923991888
     [Google Scholar]
  28. LiuH.M. ChengM.Y. XunM.H. ZhaoZ.W. ZhangY. TangW. ChengJ. NiJ. WangW. Possible mechanisms of oxidative stress-induced skin cellular senescence, inflammation, and cancer and the therapeutic potential of plant polyphenols.Int. J. Mol. Sci.2023244375510.3390/ijms2404375536835162
     [Google Scholar]
  29. Redza-DutordoirM. Averill-BatesD.A. Activation of apoptosis signalling pathways by reactive oxygen species.Biochim. Biophys. Acta Mol. Cell Res.20161863122977299210.1016/j.bbamcr.2016.09.01227646922
     [Google Scholar]
  30. SaitoY. YamamotoS. ChikenjiT.S. Role of cellular senescence in inflammation and regeneration.Inflamm. Regen.20244412810.1186/s41232‑024‑00342‑538831382
     [Google Scholar]
  31. ChinT. LeeX.E. NgP.Y. LeeY. DreesenO. The role of cellular senescence in skin aging and age-related skin pathologies.Front. Physiol.202314129763710.3389/fphys.2023.129763738074322
     [Google Scholar]
  32. BochevaG.S. SlominskiR.M. SlominskiA.T. Immunological aspects of skin aging in atopic dermatitis.Int. J. Mol. Sci.20212211572910.3390/ijms2211572934072076
     [Google Scholar]
  33. Sharifi-RadM. Anil KumarN.V. ZuccaP. VaroniE.M. DiniL. PanzariniE. RajkovicJ. Tsouh FokouP.V. AzziniE. PelusoI. Prakash MishraA. NigamM. El RayessY. BeyrouthyM.E. PolitoL. IritiM. MartinsN. MartorellM. DoceaA.O. SetzerW.N. CalinaD. ChoW.C. Sharifi-RadJ. Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases.Front. Physiol.20201169410.3389/fphys.2020.0069432714204
     [Google Scholar]
  34. BorgiaF. Li PomiF. VaccaroM. AlessandrelloC. PapaV. GangemiS. Oxidative stress and phototherapy in atopic dermatitis: Mechanisms, role, and future perspectives.Biomolecules20221212190410.3390/biom1212190436551332
     [Google Scholar]
  35. SpiersJ.G. ChenH.J.C. SerniaC. LavidisN.A. Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress.Front. Neurosci.2015845610.3389/fnins.2014.0045625646076
     [Google Scholar]
  36. HannibalK.E. BishopM.D. Chronic stress, cortisol dysfunction, and pain: A psychoneuroendocrine rationale for stress management in pain rehabilitation.Phys. Ther.201494121816182510.2522/ptj.2013059725035267
     [Google Scholar]
  37. MahmoudO. OladipoO. MahmoudR.H. YosipovitchG. Itch: From the skin to the brain – peripheral and central neural sensitization in chronic itch.Front. Mol. Neurosci.202316127223010.3389/fnmol.2023.127223037849619
     [Google Scholar]
  38. LegatF.J. Itch in atopic dermatitis – what is new?Front. Med.2021864476010.3389/fmed.2021.64476034026782
     [Google Scholar]
  39. RiazM. KhalidR. AfzalM. AnjumF. FatimaH. ZiaS. RasoolG. EgbunaC. MtewaA.G. UcheC.Z. AslamM.A. Phytobioactive compounds as therapeutic agents for human diseases: A review.Food Sci. Nutr.20231162500252910.1002/fsn3.330837324906
     [Google Scholar]
  40. ZhangN. ZhangS. DongX. Plant-derived bioactive compounds and their novel role in central nervous system disorder treatment via ATF4 targeting: A systematic literature review.Biomed. Pharmacother.202417611681110.1016/j.biopha.2024.11681138795641
     [Google Scholar]
  41. LoboV. PatilA. PhatakA. ChandraN. Free radicals, antioxidants and functional foods: Impact on human health.Pharmacogn. Rev.20104811812610.4103/0973‑7847.7090222228951
     [Google Scholar]
  42. SorrentiV. BuròI. ConsoliV. VanellaL. Recent advances in health benefits of bioactive compounds from food wastes and by-products: Biochemical aspects.Int. J. Mol. Sci.2023243201910.3390/ijms2403201936768340
     [Google Scholar]
  43. FernandesA. RodriguesP.M. PintadoM. TavariaF.K. A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging.Phytomedicine202311515482410.1016/j.phymed.2023.15482437119762
     [Google Scholar]
  44. ChandranD. Water-Ethanol azeotropic mixture as a biofriendly medium for molecular imprinting: Implications for homeotherapy.2024Available from: https://redefininghomeopathy.com/2023/ 03/10/water-ethanol-azeotropic-mixture-as-a-medium-for-molecular-imprinting/
  45. FarhanM. The promising role of polyphenols in skin disorders.Molecules202429486510.3390/molecules2904086538398617
     [Google Scholar]
  46. DębińskaA. SozańskaB. Dietary polyphenols—natural bioactive compounds with potential for preventing and treating some allergic conditions.Nutrients20231522482310.3390/nu1522482338004216
     [Google Scholar]
  47. KatiyarS. Silymarin and skin cancer prevention: Anti-inflammatory, antioxidant and immunomodulatory effects (Review).Int. J. Oncol.200526116917610.3892/ijo.26.1.16915586237
     [Google Scholar]
  48. YoonJ.H. KimM.Y. ChoJ.Y. Apigenin: A therapeutic agent for treatment of skin inflammatory diseases and cancer.Int. J. Mol. Sci.2023242149810.3390/ijms2402149836675015
     [Google Scholar]
  49. PopraditA. NakhokwikY. RobischonM. SaikiS.T. YoshimuraJ. WanasiriA. IshidaA. Soil degradation and herbicide pollution by repeated cassava monoculture within Thailand’s conservation region.PLoS One2024198030828410.1371/journal.pone.030828439106244
     [Google Scholar]
  50. OluyemiGF AfolabiRO ZamoraSC LiY McElroyD Environmental impact assessment of a plant cell-based bio-manufacturing process for producing plant natural product ingredients.Sustainability20241619851510.3390/su16198515
     [Google Scholar]
  51. ÇakmakçıR. SalıkM.A. ÇakmakçıS. Assessment and principles of environmentally sustainable food and agriculture systems.Agriculture2023135107310.3390/agriculture13051073
     [Google Scholar]
  52. ParasuramanS. Anand DavidA.V. ArulmoliR. Overviews of biological importance of quercetin: A bioactive flavonoid.Pharmacogn. Rev.20161020848910.4103/0973‑7847.19404428082789
     [Google Scholar]
  53. MirzaM.A. MahmoodS. HillesA.R. AliA. KhanM.Z. ZaidiS.A.A. IqbalZ. GeY. Quercetin as a therapeutic product: Evaluation of its pharmacological action and clinical applications—a review.Pharmaceuticals20231611163110.3390/ph1611163138004496
     [Google Scholar]
  54. BekenB. SerttasR. YaziciogluM. TurkekulK. ErdoganS. Quercetin improves inflammation, oxidative stress, and impaired wound healing in atopic dermatitis model of human keratinocytes.Pediatr. Allergy Immunol. Pulmonol.2020332697910.1089/ped.2019.113734678092
     [Google Scholar]
  55. XuD. HuM.J. WangY.Q. CuiY.L. Antioxidant activities of quercetin and its complexes for medicinal application.Molecules2019246112310.3390/molecules2406112330901869
     [Google Scholar]
  56. QiW. QiW. XiongD. LongM. Quercetin: Its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy.Molecules20222719654510.3390/molecules2719654536235082
     [Google Scholar]
  57. AghababaeiF. HadidiM. Recent advances in potential health benefits of quercetin.Pharmaceuticals2023167102010.3390/ph1607102037513932
     [Google Scholar]
  58. FrantzM.C. RozotR. MarrotL. NRF2 in dermo-cosmetic: From scientific knowledge to skin care products.Biofactors2023491326110.1002/biof.190736258295
     [Google Scholar]
  59. Najaf NajafiN. ArmideN. AkbariA. Baradaran RahimiV. AskariV.R. Quercetin a promising functional food additive against allergic Diseases: A comprehensive and mechanistic review.J. Funct. Foods202411610615210.1016/j.jff.2024.106152
     [Google Scholar]
  60. MlcekJ. JurikovaT. SkrovankovaS. SochorJ. Quercetin and its anti-allergic immune response.Molecules201621562310.3390/molecules2105062327187333
     [Google Scholar]
  61. JafariniaM. Sadat HosseiniM. kasiriN. FazelN. FathiF. Ganjalikhani HakemiM. EskandariN. Quercetin with the potential effect on allergic diseases.Allergy Asthma Clin. Immunol.20201613610.1186/s13223‑020‑00434‑032467711
     [Google Scholar]
  62. FaniaL. MorettaG. AntonelliF. ScalaE. AbeniD. AlbanesiC. MadonnaS. Multiple roles for cytokines in atopic dermatitis: From pathogenic mediators to endotype-specific biomarkers to therapeutic targets.Int. J. Mol. Sci.2022235268410.3390/ijms2305268435269828
     [Google Scholar]
  63. TanakaY. FurutaA. AsanoK. KobayashiH. Modulation of Th1/Th2 cytokine balance by quercetin in vitro.Medicines2020784610.3390/medicines708004632751563
     [Google Scholar]
  64. HouD.D. ZhangW. GaoY.L. SunY. WangH.X. QiR.Q. ChenH.D. GaoX.H. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis.Int. Immunopharmacol.20197410567610.1016/j.intimp.2019.10567631181406
     [Google Scholar]
  65. DębińskaA. New treatments for atopic dermatitis targeting skin barrier repair via the regulation of flg expression.J. Clin. Med.20211011250610.3390/jcm1011250634198894
     [Google Scholar]
  66. Moosbrugger-MartinzV. LeprinceC. MéchinM.C. SimonM. BlunderS. GruberR. DubracS. Revisiting the roles of filaggrin in atopic dermatitis.Int. J. Mol. Sci.20222310531810.3390/ijms2310531835628125
     [Google Scholar]
  67. FarhanM. RizviA. The pharmacological properties of red grape polyphenol resveratrol: Clinical trials and obstacles in drug development.Nutrients20231520448610.3390/nu1520448637892561
     [Google Scholar]
  68. LinM.H. HungC.F. SungH.C. YangS.C. YuH.P. FangJ.Y. The bioactivities of resveratrol and its naturally occurring derivatives on skin.Yao Wu Shi Pin Fen Xi2021291153810.38212/2224‑6614.115135696226
     [Google Scholar]
  69. CarlucciC.D. HuiY. ChumanevichA.P. RobidaP.A. FuselerJ.W. SajishM. NagarkattiP. NagarkattiM. OskeritzianC.A. Resveratrol protects against skin inflammation through inhibition of mast cell, sphingosine kinase-1, stat3 and nf-κb p65 signaling activation in mice.Int. J. Mol. Sci.2023247670710.3390/ijms2407670737047680
     [Google Scholar]
  70. MengT. XiaoD. MuhammedA. DengJ. ChenL. HeJ. Anti-inflammatory action and mechanisms of resveratrol.Molecules202126122910.3390/molecules2601022933466247
     [Google Scholar]
  71. MaC. WangY. DongL. LiM. CaiW. Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways.Acta Biochim. Biophys. Sin.201547320721310.1093/abbs/gmu13525651848
     [Google Scholar]
  72. MarkoM. PawliczakR. Resveratrol and its derivatives in inflammatory skin disorders—atopic dermatitis and psoriasis: A review.Antioxidants20231211195410.3390/antiox1211195438001807
     [Google Scholar]
  73. MalaguarneraL. Influence of resveratrol on the immune response.Nutrients201911594610.3390/nu1105094631035454
     [Google Scholar]
  74. KaruppagounderV. ArumugamS. ThandavarayanR.A. PitchaimaniV. SreedharR. AfrinR. HarimaM. SuzukiH. NomotoM. MiyashitaS. SuzukiK. WatanabeK. Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice.Int. Immunopharmacol.201423261762310.1016/j.intimp.2014.10.01425466270
     [Google Scholar]
  75. ZhangW. TangR. BaG. LiM. LinH. Anti-allergic and anti-inflammatory effects of resveratrol via inhibiting TXNIP-oxidative stress pathway in a mouse model of allergic rhinitis.World Allergy Organ. J.2020131010047310.1016/j.waojou.2020.10047333133334
     [Google Scholar]
  76. Caglayan SozmenS. KaramanM. Cilaker MiciliS. IsikS. Arikan AyyildizZ. BagriyanikA. UzunerN. KaramanO. Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium.PeerJ20164188910.7717/peerj.188927069818
     [Google Scholar]
  77. Sharifi-RadJ. RayessY.E. RizkA.A. SadakaC. ZgheibR. ZamW. SestitoS. RapposelliS. Neffe-SkocińskaK. ZielińskaD. SalehiB. SetzerW.N. DosokyN.S. TaheriY. El BeyrouthyM. MartorellM. OstranderE.A. SuleriaH.A.R. ChoW.C. MaroyiA. MartinsN. Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications.Front. Pharmacol.2020110102110.3389/fphar.2020.0102133041781
     [Google Scholar]
  78. MohammadiS.G. KafeshaniM. BagherniyaM. KesharwaniP. SahebkarA. Exploring Curcumin’s healing properties in the treatment of atopic dermatitis.Food Biosci.20245910414410.1016/j.fbio.2024.104144
     [Google Scholar]
  79. VollonoL. FalconiM. GazianoR. IacovelliF. DikaE. TerraccianoC. BianchiL. CampioneE. Potential of curcumin in skin disorders.Nutrients2019119216910.3390/nu1109216931509968
     [Google Scholar]
  80. PhanT.T. SeeP. LeeS.T. ChanS.Y. Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing.J. Trauma200151592793110.1097/00005373‑200111000‑0001711706342
     [Google Scholar]
  81. LinT.K. ZhongL. SantiagoJ. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils.Int. J. Mol. Sci.20171917010.3390/ijms1901007029280987
     [Google Scholar]
  82. KumariA. RainaN. WahiA. GohK.W. SharmaP. NagpalR. JainA. MingL.C. GuptaM. Wound-healing effects of curcumin and its nanoformulations: A comprehensive review.Pharmaceutics20221411228810.3390/pharmaceutics1411228836365107
     [Google Scholar]
  83. PengY. AoM. DongB. JiangY. YuL. ChenZ. HuC. XuR. Anti-inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures.Drug Des. Devel. Ther.2021154503452510.2147/DDDT.S32737834754179
     [Google Scholar]
  84. HaftcheshmehS.M. MirhafezS.R. AbediM. HeydarlouH. ShakeriA. MohammadiA. SahebkarA. Therapeutic potency of curcumin for allergic diseases: A focus on immunomodulatory actions.Biomed. Pharmacother.202215411364610.1016/j.biopha.2022.11364636063645
     [Google Scholar]
  85. HuP. LiK. PengX.X. KanY. YaoT.J. WangZ.Y. LiZ. LiuH.Y. CaiD. Curcumin derived from medicinal homologous foods: Its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis.Front. Immunol.202314123365210.3389/fimmu.2023.123365237497225
     [Google Scholar]
  86. KongZ.L. SudirmanS. LinH.J. ChenW.N. In vitro anti-inflammatory effects of curcumin on mast cell-mediated allergic responses via inhibiting FcεRI protein expression and protein kinase C delta translocation.Cytotechnology2020721819510.1007/s10616‑019‑00359‑631773429
     [Google Scholar]
  87. MokraD. JoskovaM. MokryJ. Therapeutic effects of green tea polyphenol (‒)-epigallocatechin-3-gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and apoptosis.Int. J. Mol. Sci.202224134010.3390/ijms2401034036613784
     [Google Scholar]
  88. ChiuY.H. WuY.W. HungJ.I. ChenM.C. Epigallocatechin gallate/L-ascorbic acid–loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis.Acta Biomater.202113022323310.1016/j.actbio.2021.05.03234087444
     [Google Scholar]
  89. PayneA NahashonS TakaE AdinewGM SolimanKFA Epigallocatechin-3-gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age.Biomolecules202212337110.3390/biom12030371
     [Google Scholar]
  90. HeJ. XuL. YangL. WangX. Epigallocatechin gallate is the most effective catechin against antioxidant stress via hydrogen peroxide and radical scavenging activity.Med. Sci. Monit.2018248198820610.12659/MSM.91117530428482
     [Google Scholar]
  91. MokraD. AdamcakovaJ. MokryJ. Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?Antioxidants2022118156610.3390/antiox1108156636009285
     [Google Scholar]
  92. NohS.U. ChoE.A. KimH.O. ParkY.M. Epigallocatechin-3-gallate improves Dermatophagoides pteronissinus extract-induced atopic dermatitis-like skin lesions in NC/Nga mice by suppressing macrophage migration inhibitory factor.Int. Immunopharmacol.2008891172118210.1016/j.intimp.2008.04.00218602062
     [Google Scholar]
  93. HossenI. KaiqiZ. HuaW. JunsongX. MingquanH. YanpingC. Epigallocatechin gallate (EGCG) inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells via modulating nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) signaling pathway.Food Sci. Nutr.20231184634465010.1002/fsn3.342737576060
     [Google Scholar]
  94. JooS.Y. SongY.A. ParkY.L. MyungE. ChungC.Y. ParkK.J. ChoS.B. LeeW.S. KimH.S. RewJ.S. KimN.S. JooY.E. Epigallocatechin-3-gallate inhibits LPS-induced NF-ΚB and MAPK signaling pathways in bone marrow-derived macrophages.Gut Liver20126218819610.5009/gnl.2012.6.2.18822570747
     [Google Scholar]
  95. ShimamuraY. NoakiR. KurokawaA. UtsumiM. HiraiC. KanT. MasudaS. Effect of (−)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A.Toxins (Basel)202113960910.3390/toxins1309060934564613
     [Google Scholar]
  96. HuangI.H. ChungW.H. WuP.C. ChenC.B. JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review.Front. Immunol.202213106826010.3389/fimmu.2022.106826036569854
     [Google Scholar]
  97. ChamcheuJ.C. SiddiquiI.A. AdhamiV.M. EsnaultS. BharaliD.J. BabatundeA.S. AdameS. MasseyR.J. WoodG.S. LongleyB.J. MousaS.A. MukhtarH. Chitosan-based nanoformulated (–)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis.Int. J. Nanomedicine2018134189420610.2147/IJN.S16596630057446
     [Google Scholar]
  98. FukutomiR. OhishiT. KoyamaY. PervinM. NakamuraY. IsemuraM. Beneficial effects of epigallocatechin-3-O-gallate, chlorogenic acid, resveratrol, and curcumin on neurodegenerative diseases.Molecules202126241510.3390/molecules2602041533466849
     [Google Scholar]
  99. WuS PangY HeY ZhangX PengL GuoJ A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds.Biomed. Pharmacoth.202114011174110.1016/j.biopha.2021.111741
     [Google Scholar]
  100. OkoshiK ItoS MatsuokaM KinugasaY ShimizuE TanakaK Combination of a topical anti-inflammatory drug and a moisturizer, both with a lamellar structure containing synthetic pseudo-ceramides, for the treatment of patients with mild-to-moderate atopic dermatitis.Clin. Cosmet. Investig. Dermatol.2024171569157810.2147/CCID.S467934
     [Google Scholar]
  101. SuraiP. Silymarin as a natural antioxidant: An overview of the current evidence and perspectives.Antioxidants20154120424710.3390/antiox401020426785346
     [Google Scholar]
  102. VostálováJ. TinkováE. BiedermannD. KosinaP. UlrichováJ. Rajnochová SvobodováA. Skin protective activity of silymarin and its flavonolignans.Molecules2019246102210.3390/molecules2406102230875758
     [Google Scholar]
  103. ZhangZ. LiX. SangS. McClementsD.J. ChenL. LongJ. JiaoA. WangJ. JinZ. QiuC. A review of nanostructured delivery systems for the encapsulation, protection, and delivery of silymarin: An emerging nutraceutical.Food Res. Int.202215611131410.1016/j.foodres.2022.11131435651070
     [Google Scholar]
  104. FidrusE. UjhelyiZ. FehérP. HegedűsC. JankaE.A. ParaghG. VasasG. BácskayI. RemenyikÉ. Silymarin: Friend or foe of uv exposed keratinocytes?Molecules2019249165210.3390/molecules2409165231035502
     [Google Scholar]
  105. BoiraC. ChapuisE. ScandoleraA. ReynaudR. Silymarin alleviates oxidative stress and inflammation induced by uv and air pollution in human epidermis and activates β-endorphin release through cannabinoid receptor type 2.Cosmetics20241113010.3390/cosmetics11010030
     [Google Scholar]
  106. RanjanS. GautamA. Pharmaceutical prospects of Silymarin for the treatment of neurological patients: An updated insight.Front. Neurosci.202317115980610.3389/fnins.2023.115980637274201
     [Google Scholar]
  107. RuelY. MoawadF. AlsarrafJ. PichetteA. LegaultJ. BrambillaD. PouliotR. Antiproliferative and anti-inflammatory effects of the polyphenols phloretin and balsacone C in a coculture of t cells and psoriatic keratinocytes.Int. J. Mol. Sci.20242511563910.3390/ijms2511563938891824
     [Google Scholar]
  108. SuraiP.F. SuraiA. Earle-PayneK. Silymarin and Inflammation: Food for Thoughts.Antioxidants20241319810.3390/antiox1301009838247522
     [Google Scholar]
  109. KarimiG. Hassanzadeh-JosanS. MemarB. EsmaeiliS.A. Riahi-ZanjaniB. Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screening.J. Pharmacopuncture2018212909710.3831/KPI.2018.21.01130151309
     [Google Scholar]
  110. MotaJ. Faria-SilvaC. ResendesA. SantosM.I. CarvalheiroM.C. LimaA. SimõesS. Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation.Nat. Prod. Res.202411210.1080/14786419.2024.234745238684022
     [Google Scholar]
  111. OršolićN. Allergic inflammation: Effect of propolis and its flavonoids.Molecules20222719669410.3390/molecules2719669436235230
     [Google Scholar]
  112. KawakamiT. AndoT. KimuraM. WilsonB.S. KawakamiY. Mast cells in atopic dermatitis.Curr. Opin. Immunol.200921666667810.1016/j.coi.2009.09.00619828304
     [Google Scholar]
  113. HenrietE. AbdallahF. LaurentY. GuimpiedC. ClementE. SimonM. PichonC. BarilP. Targeting TGF-β1/miR-21 pathway in keratinocytes reveals protective effects of silymarin on imiquimod-induced psoriasis mouse model.JID Innov.20233310017510.1016/j.xjidi.2022.10017536968096
     [Google Scholar]
  114. SegarraS. NaikenT. GarnierJ. HamonV. CoussayN. BernardF.X. Enhanced in vitro expression of filaggrin and antimicrobial peptides following application of glycosaminoglycans and a sphingomyelin-rich lipid extract.Vet. Sci.20229732310.3390/vetsci907032335878340
     [Google Scholar]
  115. SuzukiT. Regulation of the intestinal barrier by nutrients: The role of tight junctions.Anim. Sci. J.20209111335710.1111/asj.1335732219956
     [Google Scholar]
  116. KangJ.S. YoonW.K. HanM.H. LeeH. LeeC.W. LeeK.H. HanS.B. LeeK. YangK.H. ParkS.K. KimH.M. Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice.Int. Immunopharmacol.20088101475148010.1016/j.intimp.2008.06.00418593606
     [Google Scholar]
  117. KesharwaniS.S. JainV. DeyS. SharmaS. MallyaP. KumarV.A. An overview of advanced formulation and nanotechnology-based approaches for solubility and bioavailability enhancement of silymarin.J. Drug Deliv. Sci. Technol.20206010202110.1016/j.jddst.2020.102021
     [Google Scholar]
  118. SoleimaniV. DelghandiP.S. MoallemS.A. KarimiG. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review.Phytother. Res.20193361627163810.1002/ptr.636131069872
     [Google Scholar]
  119. ChanchalD.K. SinghK. BhushanB. ChaudharyJ.S. KumarS. VarmaA.K. AgnihotriN. GargA. An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes.Pharmacol. Res. Mod. Chin. Med.2023910032610.1016/j.prmcm.2023.100326
     [Google Scholar]
  120. WenY. WangY. ZhaoC. ZhaoB. WangJ. The pharmacological efficacy of baicalin in inflammatory diseases.Int. J. Mol. Sci.20232411931710.3390/ijms2411931737298268
     [Google Scholar]
  121. LiangW. HuangX. ChenW. The effects of baicalin and baicalein on cerebral ischemia: A review.Aging Dis.20178685086710.14336/AD.2017.082929344420
     [Google Scholar]
  122. WangP.W. LinT.Y. YangP.M. FangJ.Y. LiW.T. PanT.L. Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis- like lesions via regulating the responses of keratinocyte and macrophage.Biomed. Pharmacother.202215511379810.1016/j.biopha.2022.11379836271574
     [Google Scholar]
  123. LiangJ. ZhouY. ChengX. ChenJ. CaoH. GuoX. ZhangC. ZhuangY. HuG. Baicalin attenuates h2o2-induced oxidative stress by regulating the ampk/nrf2 signaling pathway in IPEC-J2 cells.Int. J. Mol. Sci.20232411943510.3390/ijms2411943537298392
     [Google Scholar]
  124. WangL. XianY.F. LooS.K.F. IpS.P. YangW. ChanW.Y. LinZ.X. WuJ.C.Y. Baicalin ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice through modulating skin barrier function, gut microbiota and JAK/STAT pathway.Bioorg. Chem.202211910553810.1016/j.bioorg.2021.10553834929516
     [Google Scholar]
  125. LiaoH. YeJ. GaoL. LiuY. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review.Biomed. Pharmacother.202113311091710.1016/j.biopha.2020.11091733217688
     [Google Scholar]
  126. BaoM. LiangM. SunX. MohyuddinS.G. ChenS. WenJ. YongY. MaX. YuZ. JuX. LiuX. Baicalin alleviates LPS-induced oxidative stress via NF-κB and Nrf2–HO1 signaling pathways in IPEC-J2 cells.Front. Vet. Sci.2022880823310.3389/fvets.2021.80823335146015
     [Google Scholar]
  127. ZhaoJ. WangZ. YuanZ. LvS. SuQ. Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice.Diab. Vasc. Dis. Res.2020176147916412097744110.1177/147916412097744133269624
     [Google Scholar]
  128. JungS. LeeS.Y. ChoiD. SeeH.J. KwonD.A. DoJ.R. ShonD.H. ShinH. Skullcap (Scutellaria Baicalensis) hexane fraction inhibits the permeation of ovalbumin and regulates TH1/2 immune responses.Nutrients2017911118410.3390/nu911118429143798
     [Google Scholar]
  129. BaeM.J. ShinH.S. SeeH.J. JungS.Y. KwonD.A. ShonD.H. Baicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse model of food allergy.Sci. Rep.2016613222510.1038/srep3222527561877
     [Google Scholar]
  130. LeeJ. SeoY.S. LeeA.Y. NamH.H. JiK.Y. KimT. LeeS. HyunJ.W. MoonC. ChoY. JungB. KimJ.S. ChaeS. Anti-atopic effect of Scutellaria baicalensis and Raphanus sativus on atopic dermatitis-like lesions in mice by experimental verification and compound-target prediction.Pharmaceuticals202417326910.3390/ph1703026938543055
     [Google Scholar]
  131. HungC.H. WangC.N. ChengH.H. LiaoJ.W. ChenY.T. ChaoY.W. JiangJ. LeeC.C. Baicalin ameliorates imiquimod-induced psoriasis-like inflammation in mice.Planta Med.201884151110111710.1055/a‑0622‑824229763944
     [Google Scholar]
  132. Mir-PalomoS. NácherA. Díez-SalesO. Ofelia Vila BusóM.A. CaddeoC. MancaM.L. ManconiM. FaddaA.M. SauríA.R. Inhibition of skin inflammation by baicalin ultradeformable vesicles.Int. J. Pharm.20165111232910.1016/j.ijpharm.2016.06.13627374324
     [Google Scholar]
  133. ChenY. WangY. SongS. ZhangX. WuL. WuJ. LiX. Topical application of baicalin combined with echinacoside ameliorates psoriatic skin lesions by suppressing the inflammation-related tnf signaling pathway and the angiogenesis-related vegf signaling pathway.ACS Omega2023843402604027610.1021/acsomega.3c0428137929119
     [Google Scholar]
  134. YunM.Y. YangJ.H. KimD.K. CheongK.J. SongH.H. KimD.H. CheongK.J. KimY.I. ShinS.C. Therapeutic effects of baicalein on atopic dermatitis-like skin lesions of nc/nga mice induced by dermatophagoides pteronyssinus.Int. Immunopharmacol.20101091142114810.1016/j.intimp.2010.06.02020621172
     [Google Scholar]
  135. Calderón-OliverM. Ponce-AlquiciraE. Chapter 7 - fruits: A source of polyphenols and health benefits.Natural and artificial flavoring agents and food dyesUnited StatesAcademic Press201818922810.1016/B978‑0‑12‑811518‑3.00007‑7
     [Google Scholar]
  136. TangL. GaoJ. LiX. CaoX. ZhouB. Molecular mechanisms of luteolin against atopic dermatitis based on network pharmacology and in vivo experimental validation.Drug Des. Devel. Ther.2022164205422110.2147/DDDT.S38789336530790
     [Google Scholar]
  137. PengZ. ZhangW. HongH. LiuL. Effect of luteolin on oxidative stress and inflammation in the human osteoblast cell line hFOB1.19 in an inflammatory microenvironment.BMC Pharmacol. Toxicol.20242514010.1186/s40360‑024‑00764‑438997762
     [Google Scholar]
  138. NtaloukaF. TsirivakouA. Luteolin: A promising natural agent in management of pain in chronic conditions.Front. Pain Res.20234111442810.3389/fpain.2023.111442836937566
     [Google Scholar]
  139. GendrischF. EsserP.R. SchemppC.M. WölfleU. Luteolin as a modulator of skin aging and inflammation.Biofactors202147217018010.1002/biof.169933368702
     [Google Scholar]
  140. ChenC.Y. PengW.H. TsaiK.D. HsuS.L. Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages.Life Sci.20078123-241602161410.1016/j.lfs.2007.09.02817977562
     [Google Scholar]
  141. KimJ.H. ParkT.J. ParkJ.S. KimM.S. ChiW.J. KimS.Y. Luteolin-3′-O-Phosphate inhibits lipopolysaccharide-induced inflammatory responses by regulating NF-ΚB/Mapk cascade signaling in RAW 264.7 cells.Molecules20212623739310.3390/molecules2623739334885976
     [Google Scholar]
  142. AlmatroodiS.A. AlmatroudiA. AlharbiH.O.A. KhanA.A. RahmaniA.H. Effects and mechanisms of luteolin, a plant-based flavonoid, in the prevention of cancers via modulation of inflammation and cell signaling molecules.Molecules2024295109310.3390/molecules2905109338474604
     [Google Scholar]
  143. JeonI. KimH. KangH. LeeH.S. JeongS. KimS. JangS. Anti-inflammatory and antipruritic effects of luteolin from Perilla (P. frutescens L.) leaves.Molecules20141966941695110.3390/molecules1906694124871572
     [Google Scholar]
  144. ČižmárováB. HubkováB. TomečkováV. BirkováA. Flavonoids as promising natural compounds in the prevention and treatment of selected skin diseases.Int. J. Mol. Sci.2023247632410.3390/ijms2407632437047297
     [Google Scholar]
  145. MuJ. MaH. ChenH. ZhangX. YeM. Luteolin prevents UVB-induced skin photoaging damage by modulating SIRT3/ROS/ MAPK signaling: An in vitro and in vivo studies.Front. Pharmacol.20211272826110.3389/fphar.2021.72826134526903
     [Google Scholar]
  146. GugliandoloE. PalmaE. CordaroM. D’AmicoR. PeritoreA.F. LicataP. CrupiR. Canine atopic dermatitis: Role of luteolin as new natural treatment.Vet. Med. Sci.20206492693210.1002/vms3.32532741111
     [Google Scholar]
  147. ZiyanL. YongmeiZ. NanZ. NingT. BaolinL. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models.Planta Med.200773322122610.1055/s‑2007‑96712217354164
     [Google Scholar]
  148. KelepouriD. MavropoulosA. BogdanosD.P. SakkasL.I. The role of flavonoids in inhibiting th17 responses in inflammatory arthritis.J. Immunol. Res.20182018111110.1155/2018/932435729693024
     [Google Scholar]
  149. SalehiB. VendittiA. Sharifi-RadM. KręgielD. Sharifi-RadJ. DurazzoA. LucariniM. SantiniA. SoutoE.B. NovellinoE. AntolakH. AzziniE. SetzerW.N. MartinsN. The therapeutic potential of apigenin.Int. J. Mol. Sci.2019206130510.3390/ijms2006130530875872
     [Google Scholar]
  150. AllemailemK.S. AlmatroudiA. AlharbiH.O.A. AlSuhaymiN. AlsugoorM.H. AldakheelF.M. KhanA.A. RahmaniA.H. Apigenin: A bioflavonoid with a promising role in disease prevention and treatment.Biomedicines2024126135310.3390/biomedicines1206135338927560
     [Google Scholar]
  151. GuoW. XingY. LuoX. LiF. RenM. LiangY. Reactive oxygen species: A crosslink between plant and human eukaryotic cell systems.Int. J. Mol. Sci.202324171305210.3390/ijms24171305237685857
     [Google Scholar]
  152. HosseinzadeA. SadeghiO. Naghdipour BireganiA. SoukhtehzariS. BrandtG.S. EsmaillzadehA. Immunomodulatory effects of flavonoids: Possible induction of T CD4+ regulatory cells through suppression of mTOR pathway signaling activity.Front. Immunol.2019105110.3389/fimmu.2019.0005130766532
     [Google Scholar]
  153. ParkC.H. MinS.Y. YuH.W. KimK. KimS. LeeH.J. KimJ.H. ParkY.J. Effects of apigenin on RBL-2H3, RAW264.7, and HaCaT cells: Anti-allergic, anti-inflammatory, and skin-protective activities.Int. J. Mol. Sci.20202113462010.3390/ijms2113462032610574
     [Google Scholar]
  154. YanoS. UmedaD. YamashitaS. YamadaK. TachibanaH. Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice.J. Nutr. Biochem.2009201187688110.1016/j.jnutbio.2008.08.00218993046
     [Google Scholar]
/content/journals/cpd/10.2174/0113816128368673250611114044
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Harnessing Antioxidant Properties of Plant-Derived Bioactive Compounds to Alleviate Atopic Dermatitis Symptoms: A Review
Curr. Pharm. Des. 32, 1013 (2026); https://doi.org/10.2174/0113816128368673250611114044
/content/journals/cpd/10.2174/0113816128368673250611114044
/content/journals/cpd/10.2174/0113816128368673250611114044
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  • Article Type:     Review Article
Keyword(s): Antioxidants; atopic dermatitis; inflammation management; oxidative stress; plant-derived compounds, erythema

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