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image of Hypoglycaemic, Hypolipidemic and Antioxidant Activities of Hibiscus cannabinus in Diabetes-induced Male Wistar Rat

Abstract

Introduction

Diabetes is a chronic metabolic disease that affects individuals of all ages. Therefore, there is an urgent need to develop novel therapeutic agents from natural sources. In this context, was selected for the present investigation. The study aimed to evaluate the hypoglycemic, hypolipidemic, and antioxidant activities of extract in a streptozotocin-induced diabetic model in Wistar rats.

Methods

An study was planned to evaluate the hypoglycaemic, hypolipidemic, and antioxidant effects activities of HCE. Thirty-six male Wistar rats were randomly divided into six groups, and diabetes was induced by a single acute intraperitoneal injection of STZ. Animals were treated orally with HCE at doses of 100, 200, and 400 mg/kg b.wt., or with Glibenclamide (5 mg/kg b.wt.), along with a normal control group. The rats were monitored for body weight, feed intake, blood glucose and insulin levels, lipid profile, and markers of lipid peroxidation and antioxidant activity.

Results

HCE showed a significant reduction in blood glucose levels, improved lipid profile, enhanced antioxidant enzyme activity, and decreased lipid peroxidation in diabetic rats in a dose-dependent manner compared with the control group. Notably, the 400 mg/kg b.wt. HCE group exhibited efficacy comparable to that of the Glibenclamide treatment group.

Discussion

HCE showed activity in streptozotocin-induced diabetic rats, indicating its potential as a natural therapeutic agent. Further investigation into its mechanisms and clinical applicability for managing diabetes-related complications is needed to support its pharmaceutical use.

Conclusion

HCE extract exhibited strong antidiabetic, lipid-lowering, and antioxidant activities in STZ-induced diabetic rats.

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2026-01-28
2026-02-19

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/content/journals/cpb/10.2174/0113892010378159251124093801
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Hypoglycaemic, Hypolipidemic and Antioxidant Activities of Hibiscus cannabinus in Diabetes-induced Male Wistar Rat
Bentham Science Publishers ; https://doi.org/10.2174/0113892010378159251124093801
/content/journals/cpb/10.2174/0113892010378159251124093801
/content/journals/cpb/10.2174/0113892010378159251124093801
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  • Article Type:     Research Article
Keywords: diabetic ; Hyperglycemic ; Hibiscus cannabinus ; hyperlipidemic ; antioxidant activities ; acute toxicity ; Rat

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