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image of Ganoderma lucidum: A Medicinal Mushroom with Prebiotic and Anticancer Potential in Gastrointestinal Cancers

Abstract

Introduction

is considered a medicinal mushroom, as it primarily improves gut health by modulating the gut microbiota. As an abundant source of bioactive metabolites, antioxidants, and industrial enzymes, mushrooms make significant contributions to functional foods, nutrition, and pharmaceuticals. Polysaccharides derived from exhibit prebiotic potential, promoting the growth and activity of beneficial gut microorganisms.

Methods

This systematic review examines the impact of white rot basidiomycetes metabolites on colorectal cancer treatment. We have compiled and analyzed data from PubMed, Google Scholar, and ResearchGate, presenting a comprehensive report with a table for clear understanding.

Results

Evidence from and studies demonstrates that has potential as a gastrointestinal cancer inhibitor by inducing pro-apoptosis, autophagy, G0/G1 cell cycle arrest, and immunomodulation.

Discussion

Bioactive metabolites and polysaccharides have prebiotic potential, enhancing the growth and activity of beneficial gut microorganisms that may lower the risk of gastrointestinal cancers by modifying gut bacteria. The prebiotic properties may boost immunity, reduce inflammation, and strengthen intestinal barrier integrity.

Conclusion

The current review explores the therapeutic potential of and other medicinal mushrooms as dietary supplements, focusing on their impact on the gut microbiome and gastrointestinal cancer.

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2025-10-28
2025-12-20

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Ganoderma lucidum: A Medicinal Mushroom with Prebiotic and Anticancer Potential in Gastrointestinal Cancers
Bentham Science Publishers ; https://doi.org/10.2174/0113892010377275250930170651
/content/journals/cpb/10.2174/0113892010377275250930170651
/content/journals/cpb/10.2174/0113892010377275250930170651
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  • Article Type:     Review Article
Keywords: gut microbiome ; medicinal mushrooms ; Ganoderma lucidum ; secondary metabolites ; prebiotics ; colorectal cancer

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