Skip to content
2000
Volume 27, Issue 1
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Objective

The objective of this study is to conduct network toxicology analysis based on smoking habits and develop a simpler and more effective toxicology product ingestion control system.

Background

Smoking behavior can affect the pathogenesis and prognosis of neuroimmune gastrointestinal diseases.

Aims

The purpose of developing tools to assist clinical practice is to avoid the harm of cigarettes to the human body.

Methods

Molecular dynamics method was used to elucidate the biophysical mechanism of TP53 gene mutation caused by harmful ingredients, and the signaling pathway of midbrain edge excitation was determined by molecular dynamics of nicotine and dopamine receptor D3. The possible involvement of nicotine in neuronal damage was determined through the molecular interaction between nicotine and ACHE. Molecular pathways were analyzed based on the aforementioned biological principles, developed artificial intelligence systems and brain computer interface systems.

Results

Several signaling pathways were elucidated, and effective AI algorithms were developed.

Conclusion

The accuracy of artificial intelligence systems is over 70%. This study provides clinical doctors with a new precision medicine strategy and tool to regulate patient behavior and reduce disease risk.

Other

This project was approved by the Ethics Committee of Chifeng Cancer Hospital and reported to the WHO.

© 2026 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cpb/10.2174/0113892010348489241210060447
2025-02-18
2026-03-09

  • From This Site

    /content/journals/cpb/10.2174/0113892010348489241210060447
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. VillotaO.P.M. CentenoL.J.A. LugonesJ. MinuzziP.G. VareaS.M. Comparison between the risk calculators of the european randomized study for screening of prostate cancer (ERSPC) and the prostate biopsy collaborative group (PBCG): Prediction of the risk of clinically significant prostate cancer in a cohort of patients from argentina.Actas Urol. Esp.202448321021710.1016/j.acuro.2023.07.008 37827241
     [Google Scholar]
  2. HatsukamiD.K. JensenJ.A. CarrollD.M. LuoX. StrayerL.G. CaoQ. HechtS.S. MurphyS.E. CarmellaS.G. ApteD.R.L. ColbyS. StrasserA.A. McClernonF.J. TideyJ. BenowitzN.L. DonnyE.C. Reduced nicotine in cigarettes in a marketplace with alternative nicotine systems: Randomized clinical trial.Lancet Reg. Health Am.20243510079610.1016/j.lana.2024.100796 38911348
     [Google Scholar]
  3. YuI.L. CoyleJ.T. DesaiR.I. Impact of serine racemase deletion on nicotine discrimination.Nicotine Tob. Res.2024ntae15610.1093/ntr/ntae156 38919117
     [Google Scholar]
  4. RoseS.W. TanA.S.L. BandiP. MaddoxR. BermanM. CzaplickiL. FaseruB. FrazerK. ChoiK. Commercial tobacco and nicotine industry-funded research has no place in SRNT and nicotine & tobacco research.Nicotine Tob. Res.202426896396510.1093/ntr/ntae109 38703079
     [Google Scholar]
  5. ImilowskiW.N. BeckerP. GielischM.W. ZiebolzD. VermehrenF. BitschnauM. LangguthN. BriegerJ. DeschnerJ. KämmererP.W. Cytotoxic impact of nicotine products on periodontal ligament cells.Clin. Oral Investig.202428739910.1007/s00784‑024‑05797‑x 38922383
     [Google Scholar]
  6. CarmonaM.R. PratS.M. ColomerS.J. FerroT. LavadoÀ. Effect of frailty in health resource use in aged cancer patients.Gac. Sanit.20243810236010236010.1016/j.gaceta.2024.102360 38460206
     [Google Scholar]
  7. LevyD.T. CummingsK.M. VillantiA.C. NiauraR. AbramsD.B. FongG.T. BorlandR. A framework for evaluating the public health impact of E-cigarettes and other vaporized nicotine products.Addiction2017112181710.1111/add.13394 27109256
     [Google Scholar]
  8. BoccioC.M. Low self-control, peer risk factors, and adolescent vaping activity.Crime Delinq.20247092514253110.1177/00111287231160739
     [Google Scholar]
  9. ZhangF. ShiJ. YuJ. ZhaoY. FanR. WangX. LiZ. Development and characterization of tobacco suspension cell chassis NBS-1.Chin. J. Biotechnol.202440619351949 38914502
     [Google Scholar]
  10. NianQ. HardestyJ.J. CrespiE. SinamoJ. KennedyR.D. WeldingK. CohenJ.E. Is maintenance or switching between freebase and nicotine salt liquid associated with electronic nicotine delivery systems dependence?Subst. Use Misuse202459111613161910.1080/10826084.2024.2369154 38918934
     [Google Scholar]
  11. TotonjiS. MetzgerE. UrbanS. WillmannD. BauerH. SumM. SchüleR. The histone methyltransferase KMT9 regulates proliferation and migration of bladder cancer cells and is a novel target for treatment of muscle invasive bladder cancer (MIBC).Eur. Urol.202485S22710.1016/S0302‑2838(24)00240‑9
     [Google Scholar]
  12. HasbaniE.G. NassarE.J. AliE.A.M. UthmanI. JawadA. The impact of nicotine smoking on spondyloarthritis and rheumatoid arthritis.Reumatismo2024762157210.4081/reumatismo.2024.1572 38916171
     [Google Scholar]
  13. AsgharianB. PriceO. WasdoS. LiC. PetersK.O. HaskinsR.M. ChemerynskiS. SchroeterJ. The fate of an inhaled cigarette puff in the human respiratory tract.Inhal. Toxicol.202436637839010.1080/08958378.2024.2367419 38909354
     [Google Scholar]
  14. YinW. FigielS. HeM. TeagueR. AnbarasanT. RanasinhaN. SinghR. PouloseN. DoultsinosD. AbusamraS. EricksonA. LodaM. VerrillC. CollingR. GillP. BryantR. CussenotO. HamdyF. WoodcockD. MillsI. LundebergJ. LambA. PD09-08 spatial transcriptomic clonal deconvolution identifies the ‘Lethal Clone’ in prostate cancer as defined by ability to metastasize to lymph nodes.J. Urol.20242115Se18210.1097/01.JU.0001008572.33286.63.08
     [Google Scholar]
  15. SankeyC.J. CapriaL.K. GlasserA. PadonA.A. MoranM.B. WagonerK.G. JacksonK.M. BergC.J. Associations between E-cigarette marketing exposure and vaping nicotine and cannabis among U.S. adults, 2021.Addict. Behav.202415710809010.1016/j.addbeh.2024.108090 38880059
     [Google Scholar]
  16. ReedG.L. ColbyS.M. DiLorenzoJ. TottenJ. TideyJ.W. CassidyR.N. Reactions to a nicotine reduction policy among adolescents who smoke: A qualitative study.Nicotine Tob. Res.2024ntae15310.1093/ntr/ntae153 38908011
     [Google Scholar]
  17. ChengH.G. RoseJ.E. KarelitzJ.L. BottsD.R. BottsT.L. WilletteP.N. CohenG. Effect of flavored on! nicotine pouch products on smoking behaviors: Protocol for a sequential, multiple assignment, randomized controlled trial.JMIR Res. Protoc.2024131e5656510.2196/56565 38905632
     [Google Scholar]
  18. MohammadiH. ZardoshtZ. MoeinH. HassaniG. The effect of climatic variables and techno-structural factors on the water pollution caused by nicotine leakage from littered cigarette butts.Environ. Sci. Pollut. Res. Int.20243131437044371110.1007/s11356‑024‑34049‑4 38907063
     [Google Scholar]
  19. WangK. XuL. MaJ. ZhouY. JiangY. ZhaJ. CaiY. HeJ. JiangJ. QiuJ. MuY. Characterization of cotinine degradation in a newly isolated Gram-negative strain Pseudomonas sp. JH-2.Arch. Microbiol.2024206731610.1007/s00203‑024‑04036‑x 38904699
     [Google Scholar]
  20. KimH. GartnerC. EdwardsR. PuljevićC. MorphettK. KimD.H. ChunH. EkdahlM. KangH. Public support for tobacco endgame policies: A systematic review and meta-analysis.Nicotine Tob. Res.2024ntae14910.1093/ntr/ntae149 38890771
     [Google Scholar]
  21. ZhangH. HanS. FanL. LiuG. ZhangY. ChenH. HouH. HuQ. The difference of addictive behavior of freebase nicotine and nicotine salts in mice base on an aerosol self-administration model.Nicotine Tob. Res.2024ntae15010.1093/ntr/ntae150 38894545
     [Google Scholar]
  22. JacksonS.E. BrownJ. ShahabL. ArnottD. BauldL. CoxS. Nicotine strength of e‐liquids used by adult vapers in great britain: A population survey 2016 to 2024.Addiction2024add.1657610.1111/add.16576 38897583
     [Google Scholar]
  23. EissenbergT. ShihadehA. Understanding the nicotine dose delivered by electronic nicotine delivery systems in a single puff: The importance of nicotine flux and puff duration.Tob. Control2024tc-202305848510.1136/tc‑2023‑058485 38897725
     [Google Scholar]
  24. LuoF. HuangC. New insight into neuropathic pain: The relationship between α7nAChR, ferroptosis, and neuroinflammation.Int. J. Mol. Sci.20242512671610.3390/ijms25126716 38928421
     [Google Scholar]
  25. TravisN. WarnerK.E. GoniewiczM.L. OhH. RanganathanR. MezaR. BoyceH.J. LevyD.T. The potential impact of oral nicotine pouches on public health: A scoping review.Nicotine Tob. Res.2024ntae13110.1093/ntr/ntae131 38880491
     [Google Scholar]
/content/journals/cpb/10.2174/0113892010348489241210060447
Loading
Research on Precision Medicine AI Algorithm for Neuro Immune Gastrointestinal Diseases based on Quantum Biochemistry and Computational Cancer Genetics
Current Pharmaceutical Biotechnology 27, 36 (2026); https://doi.org/10.2174/0113892010348489241210060447
/content/journals/cpb/10.2174/0113892010348489241210060447
/content/journals/cpb/10.2174/0113892010348489241210060447
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher's website along with the published article.

file format download Download

  • Article Type:     Research Article
Keyword(s): artificial intelligence; bioinformatics; molecular dynamics; molecular mechanisms; Precision medicine; quantum physics

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test