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2000
Volume 26, Issue 6
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Background

Anti-Mullerian hormone (AMH) plays a pivotal role in follicular growth and atresia. Recent studies highlighted the role of AMH in attenuating granulosa cell apoptosis and subsequent follicular atresia. Despite the raising understanding of the role of AMH in folliculogenesis, and its contribution to the pathophysiology of certain diseases such as polycystic ovary syndrome, the effect of AMH on the expression of genes regulating folliculogenesis is stills limited.

Objective

This study aims to gain insights into the effect of AMH on atresia regulating genes.

Methods

study was performed on C57BL/6J mice injected with AMH for one month. Thereafter, relative gene expression quantification of , Sirt1, p53, Bim, and Bax genes were performed using RT-PCR.

Results

In this study, AMH significantly enhanced the expression of and Sirt1 gene compared to the control group. On the contrary, AMH did not modulate the expression of p53, Bim, or Bax genes. AMH was also found to increase serum FSH and LH levels in a dose-dependent manner.

Conclusion

This study demonstrated the capability of AMH to induce and genes. Moreover, our study revealed the role of AMH in elevating LH serum level which is a main contributor to the pathophysiology of polycystic ovary syndrome, opening new avenues for the study of AMH as a main contributor to the stalled follicular atresia and growth associated with the disease.

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2025-09-16

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/content/journals/cpb/10.2174/0113892010293250240917143811
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Anti-Mullerian Hormone Induces Foxo1 and Sirt1 Genes Expression in Mouse Ovary
Current Pharmaceutical Biotechnology 26, 872 (2025); https://doi.org/10.2174/0113892010293250240917143811
/content/journals/cpb/10.2174/0113892010293250240917143811
/content/journals/cpb/10.2174/0113892010293250240917143811
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  • Article Type:     Research Article
Keyword(s): Anti-Mullerian hormone (AMH); atresia; Bax; Bim; Foxo1; p53; Polycystic ovary syndrome (PCOS); Sirt1

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