Current Pharmaceutical Analysis - Volume 19, Issue 3, 2023

Cell phones are like a notepad PC with their own working framework, processor, interior memory, and top-notch camera focal points. Cell phones are more open and less expensive than versatile analytical devices. The quantity of cell phone users overall outperformed 2 billion in 2016 and it addresses more than a fourth of the worldwide population. There have been numerous new articles on the utilization of cell phones as v Read More

Background: For the development of robust analytical methods, Analytical-Qualityby- Design (AQbD)-based testing methods have been found to be more suited than other one factorial approaches. By creating a Method Operable Design Space, this strategy selects the optimal method conditions using the appropriate Design of Experiments. Objective: To impart knowledge to the researchers producing methods using this techniqu Read More

Background: A reversed-phase high-performance liquid chromatographic method for determining thrombin activity is described. The improved method can provide a high resolution between substrate Nα-P-toluenesulfonyl-L-arginine methyl ester (TAME) and the product of enzyme reaction, Nα-P-toluenesulfonyl-L-Arginine (TA). Methods: When the substrate concentration was 5 mg/mL, the Michaelis equation approached the Read More

Background: Knee osteoarthritis (KOA) is a clinically common degenerative joint disease that is not fatal but has a high prevalence. Synovitis ointment (HMYG) is a traditional Chinese medicine formula that has been clinically proven to treat KOA; however, its therapeutic targets remain unknown. Objective: This study aimed to identify metabolites and potential targets of synovitis ointment alleviation in rats with KOA usin Read More

Objective: The aim of this study was to propose an easy, fast, and precise method, which can be satisfactorily applied to the simultaneous determination of the drugs in pharmaceutical dosage forms instead of the high-performance liquid chromatography (HPLC) method. Methods: Complicated and costly instruments, as well as spending a lot of time for analysis are the limitations of the chromatography method. He Read More

Background: As an external medicine, policresulen solution didn't get much attention throughout the world. From the paper which had been published yet, there has been no report concerning other unknown impurities in the policresulen solution. Four known components had been identified as well as quantified, however, as long as people’s concern for drug safety increased rapidly, there still remain impurities to b Read More

Background: Successful drug extraction from biological fluids is challenging due to interfering factors and the trace levels of the target analytes. Objective: We aimed to provide a suitable and sensitive method to increase the efficiency of methotrexate extraction from biological fluids. Methods: Chitosan-based nanogel synthesized by the ionic gelation method was used for solidphase microextraction of methotrexate fro Read More