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2000
Volume 6, Issue 4
  • ISSN: 2666-7967
  • E-ISSN: 2666-7975

Abstract

The COVID-19 pandemic and lockdown have sparked global terror and apprehension. This phenomenon has led to short-term as well as long-term psychosocial and mental health implications for all. This paper aims at reviewing the prevalence, pathophysiology and treatment of various neuropsychiatric disorders in the pandemic era. We conducted a review and collected articles before and during the COVID-19 pandemic and presented a comparative study of the prevalence of neuropsychiatric disorders before COVID-19 and during COVID-19 pandemic. We selected articles and thematically organized them. Prevalence, pathophysiology, and treatment techniques were studied. We can conclude that the time has come to ensure that the special opportunities presented by this pandemic can translate advocacy to resourcing, ensuring that actionable outputs are delivered for better mental health services. This is necessary given the ground level as well as grassroots support for increased funding for mental health services as well as the apparent desire across all sectors for improved service provision. Longitudinal investigations are required for the assessment of long-lived psychological disorders of the COVID-19 pandemic. The findings need comprehensive evaluation and rehabilitation post-COVID-19 to promote quality of life.

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2024-07-08
2025-10-03

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References

  1. GiorgiG. LeccaL.I. AlessioF. COVID-19-related mental health effects in the workplace: a narrative review.Int. J. Environ. Res. Public Health202017217857787910.3390/ijerph17217857 33120930
     [Google Scholar]
  2. PatelA. KumarS. SaxenaM. A review of remdesivir: As a lifesaver in the pandemic of SARS-CoV-2.Int J Res Rev202291153854810.52403/ijrr.20221170
     [Google Scholar]
  3. Clemente-SuárezV.J. Martínez-GonzálezM.B. Benitez-AgudeloJ.C. The impact of the COVID-19 pandemic on mental disorders. A critical review.Int. J. Environ. Res. Public Health20211819100411006610.3390/ijerph181910041 34639341
     [Google Scholar]
  4. Ramírez-MorenoJ.M. Muñoz-SanzA. Vaz-LealF.J. Cognitive function and neuropsychiatric disorders after COVID-19: A long term social and clinical problem?BioMed202221505910.3390/biomed2010005
     [Google Scholar]
  5. ShanbehzadehS. TavahomiM. ZanjariN. Ebrahimi-TakamjaniI. Amiri-arimiS. Physical and mental health complications post-COVID-19: Scoping review.J. Psychosom. Res.202114711052510.1016/j.jpsychores.2021.110525 34051516
     [Google Scholar]
  6. FavreauM. HillertA. OsenB. Psychological consequences and differential impact of the COVID-19 pandemic in patients with mental disorders.Psychiatry Res.202130211404510.1016/j.psychres.2021.114045 34126461
     [Google Scholar]
  7. De KockJ.H. LathamH.A. LeslieS.J. A rapid review of the impact of COVID-19 on the mental health of healthcare workers: implications for supporting psychological well-being.BMC Public Health202121110410.1186/s12889‑020‑10070‑3 33422039
     [Google Scholar]
  8. BadenochJ.B. RengasamyE.R. WatsonC. Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis.Brain Commun.202241fcab29710.1093/braincomms/fcab297 35169700
     [Google Scholar]
  9. ŁojekE. EgbertA. GambinM. Neuropsychological disorders after COVID-19. Urgent need for research and clinical practice.Adv Psych Neurol2021302104112
     [Google Scholar]
  10. Semyachkina-GlushkovskayaO. MamedovaA. VinnikV. Brain mechanisms of COVID-19-sleep disorders.Int. J. Mol. Sci.202122136917693810.3390/ijms22136917 34203143
     [Google Scholar]
  11. TsivgoulisG. PalaiodimouL. KatsanosA.H. Neurological manifestations and implications of COVID-19 pandemic.Ther. Adv. Neurol. Disord.20201310.1177/1756286420932036 32565914
     [Google Scholar]
  12. BoldriniM. CanollP.D. KleinR.S. How COVID-19 affects the brain.JAMA Psychiatry202178668268310.1001/jamapsychiatry.2021.0500 33769431
     [Google Scholar]
  13. PandyaA. LodhaP. Social connectedness, excessive screen time during COVID-19 and mental health: a review of current evidence.Front Human Dyn2021368413710.3389/fhumd.2021.684137
     [Google Scholar]
  14. TangS.W. LeonardB.E. HelmesteD.M. Long COVID, neuropsychiatric disorders, psychotropics, present and future.Acta Neuropsychiatr.202234310912610.1017/neu.2022.6 35144718
     [Google Scholar]
  15. De MirandaA.S. TeixeiraA.L. Coronavirus disease-2019 conundrum: RAS blockade and geriatric-associated neuropsychiatric disorders.Front. med.2020117515
     [Google Scholar]
  16. WanY.M. DengX. TanE.K. Olfactory dysfunction and COVID-19.Lancet Psych20207866310.1016/S2215‑0366(20)30253‑4 32711700
     [Google Scholar]
  17. MazzaM.G. De LorenzoR. ConteC. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors.Brain Behav. Immun.20208959460010.1016/j.bbi.2020.07.037 32738287
     [Google Scholar]
  18. RaffagnatoA. IannattoneS. TasciniB. The COVID-19 pandemic: a longitudinal study on the emotional-behavioral sequelae for children and adolescents with neuropsychiatric disorders and their families.Int. J. Environ. Res. Public Health202118189880989910.3390/ijerph18189880 34574803
     [Google Scholar]
  19. NakamuraZ.M. NashR.P. LaughonS.L. RosensteinD.L. Neuropsychiatric complications of COVID-19.Curr. Psychiatry Rep.20212352510.1007/s11920‑021‑01237‑9 33725218
     [Google Scholar]
  20. LiuX. ZhuM. ZhangR. Public mental health problems during COVID-19 pandemic: a large-scale meta-analysis of the evidence.Transl. Psychiatry202111138410.1038/s41398‑021‑01501‑9 34244469
     [Google Scholar]
  21. SagarR. DandonaR. GururajG. The burden of mental disorders across the states of India: the Global Burden of Disease Study 1990–2017.Lancet Psychiatry20207214816110.1016/S2215‑0366(19)30475‑4 31879245
     [Google Scholar]
  22. SidhuM. PrahbhjotM. PandeyaN. Psychological impact of the COVID-19 pandemic among adults in India: A longitudinal study.Indian J. Public Health202266332332610.4103/ijph.ijph_1034_21 36149113
     [Google Scholar]
  23. TondoG. AprileD. TesserF. ComiC. Increased prevalence of neuropsychiatric disorders during COVID-19 pandemic in people needing a non-deferrable neurological evaluation.J. Clin. Med.202110215169517910.3390/jcm10215169 34768689
     [Google Scholar]
  24. KumarS. VeldhuisA. MalhotraT. Neuropsychiatric and cognitive sequelae of COVID-19.Front. Psychol.20211257752910.3389/fpsyg.2021.577529 33737894
     [Google Scholar]
  25. BenzakourL. BondolfiG. Update of the potential treatments for psychiatric and neuropsychiatric symptoms in the context of the post-COVID-19 condition: still a lot of suffering and many more things to learn.Trauma Care20222213115010.3390/traumacare2020011
     [Google Scholar]
  26. AsnakewS. LegasG. Muche LiyehT. Prevalence of post-traumatic stress disorder on health professionals in the era of COVID-19 pandemic, Northwest Ethiopia, 2020: A multi-centered cross-sectional study.PLoS One2021169e025534010.1371/journal.pone.0255340 34520471
     [Google Scholar]
  27. BhandariR. Online yoga and ayurveda intervention as tertiary prevention of psychological comorbidities in COVID-19 survivors: a randomized controlled trial.Ann. Neurosci.202229423324410.1177/09727531221117623 37064289
     [Google Scholar]
  28. YuanK. GongY.M. LiuL. Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review.Mol. Psychiatry20212694982499810.1038/s41380‑021‑01036‑x 33542468
     [Google Scholar]
  29. ButaricL.N. RichmanA. GarvinH.M. The effects of cranial orientation on forensic frontal sinus identification as assessed by outline analyses.Biology20221116210.3390/biology11010062 35053060
     [Google Scholar]
  30. PanchalN. KamalR. OrgeraK. Kaiser family foundation.The implications of COVID-19 for mental health and substance use.2020Available from: https://www.kff.org/mental-health/issue-brief/the-implications-of-COVID-19-for-mental-health-and-substance-use/ (accessed on 10-6-2024)
     [Google Scholar]
  31. VarmaP. JungeM. MeaklimH. JacksonM.L. Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: A global cross-sectional survey.Prog. Neuropsychopharmacol. Biol. Psychiatry202110911023610.1016/j.pnpbp.2020.110236 33373680
     [Google Scholar]
  32. LöweB. GräfeK. ZipfelS. Detecting panic disorder in medical and psychosomatic outpatients.J. Psychosom. Res.200355651551910.1016/S0022‑3999(03)00072‑2 14642981
     [Google Scholar]
  33. DalknerN. RatzenhoferM. FleischmannE. Psychological and behavioral response on the COVID-19 pandemic in individuals with bipolar disorder: A multicenter study.Psychiatry Res.202231011445110.1016/j.psychres.2022.114451 35190338
     [Google Scholar]
  34. MazzaM. MaranoG. JaniriL. SaniG. Managing bipolar disorder patients during COVID‐19 outbreak.Bipolar Disord.202022887087110.1111/bdi.13015 33012116
     [Google Scholar]
  35. Hernández-GómezA. Andrade-GonzálezN. LaheraG. VietaE. Recommendations for the care of patients with bipolar disorder during the COVID-19 pandemic.J. Affect. Disord.202127911712110.1016/j.jad.2020.09.105 33045553
     [Google Scholar]
  36. YocumA.K. ZhaiY. McInnisM.G. HanP. COVID-19 pandemic and lockdown impacts: A description in a longitudinal study of bipolar disorder.J. Affect. Disord.20212821226123310.1016/j.jad.2021.01.028 33601700
     [Google Scholar]
  37. StefanaA. YoungstromE.A. ChenJ. The COVID‐19 pandemic is a crisis and opportunity for bipolar disorder.Bipolar Disord.202022664164310.1111/bdi.12949 32511859
     [Google Scholar]
  38. PartinenM. HolzingerB. MorinC.M. Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire.BMJ Open20211112e050672e1010.1136/bmjopen‑2021‑050672 34903540
     [Google Scholar]
  39. AlimoradiZ. BroströmA. TsangH.W.H. Sleep problems during COVID-19 pandemic and its’ association to psychological distress: A systematic review and meta-analysis.EClinicalMedicine20213610091610093010.1016/j.eclinm.2021.100916 34131640
     [Google Scholar]
  40. MelloM.T. SilvaA. GuerreiroR.C. Sleep and COVID-19: considerations about immunity, pathophysiology, and treatment.Sleep Sci.202013319920910.5935/1984‑0063.20200062 33381288
     [Google Scholar]
  41. BhatS. ChokrovertyS. Sleep disorders and COVID-19.Sleep Med.20229125326110.1016/j.sleep.2021.07.021 34391672
     [Google Scholar]
  42. NeedhamE.J. ChouS.H.Y. ColesA.J. MenonD.K. Neurological implications of COVID-19 infections.Neurocrit. Care202032366767110.1007/s12028‑020‑00978‑4 32346843
     [Google Scholar]
  43. JohanssonA. MohamedM.S. MoulinT.C. SchiöthH.B. Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms.J. Neuroimmunol.202135857765810.1016/j.jneuroim.2021.577658 34304141
     [Google Scholar]
  44. TripathiK.D. Essentials of Medical Pharmacology.2019940
     [Google Scholar]
  45. HetrickSE McKenzieJE BaileyAP New generation antidepressants for depression in children and adolescents: A network meta‐analysis.Coch Database Sys Rev202155CD01367410.1002/14651858.CD013674 34029378
     [Google Scholar]
  46. VadivelR. ShoibS. El HalabiS. Mental health in the post-COVID-19 era: challenges and the way forward.Gen. Psychiatr.2021341e10042410.1136/gpsych‑2020‑100424 33644689
     [Google Scholar]
  47. ZopeC. ZopeS. ZopeR.A. BiriG.A. Sudarshan kriya yoga: A breath of hope during COVID-19 pandemic.Int. J. Yoga2021141182510.4103/ijoy.IJOY_102_20 33840973
     [Google Scholar]
  48. MishraL.C. Healthcare ani disease management in ayurveda.Altern. Ther. Health Med.200172
     [Google Scholar]
  49. TilluG. ChaturvediS. ChopraA. PatwardhanB. Public health approach of ayurveda and yoga for COVID-19 prophylaxis.J. Altern. Complement. Med.202026536036410.1089/acm.2020.0129 32310670
     [Google Scholar]
  50. UmeshC. RamakrishnaK.K. JastiN. BhargavH. VaramballyS. Role of Ayurveda and Yoga-Based lifestyle in the COVID-19 pandemic – A narrative review.J. Ayurveda Integr. Med.202213110049310.1016/j.jaim.2021.07.009 34305355
     [Google Scholar]
  51. SharmaK. AnandA. KumarR. The role of Yoga in working from home during the COVID-19 global lockdown.Work202066473173710.3233/WOR‑203219 32925134
     [Google Scholar]
  52. FannJ.R. BerryD.L. WolpinS. Depression screening using the Patient Health Questionnaire‐9 administered on a touch screen computer.Psychooncology2009181142210.1002/pon.1368 18457335
     [Google Scholar]
  53. BinDhimN.F. ShamanA.M. TrevenaL. BasyouniM.H. PontL.G. AlhawassiT.M. Depression screening via a smartphone app: cross-country user characteristics and feasibility.J. Am. Med. Inform. Assoc.2015221293410.1136/amiajnl‑2014‑002840 25326599
     [Google Scholar]
  54. KimM.H. ChungK.M. Brief Report: Development of app-based CBT program for depressive college students: Mind booster green.APA Open2021
     [Google Scholar]
  55. WhitesideS.P.H. AleC.M. Vickers DouglasK. TiedeM.S. DammannJ.E. Case examples of enhancing pediatric OCD treatment with a smartphone application.Clin. Case Stud.2014131809410.1177/1534650113504822
     [Google Scholar]
  56. TorousJ. PowellA.C. Current research and trends in the use of smartphone applications for mood disorders.Internet Interv.20152216917310.1016/j.invent.2015.03.002
     [Google Scholar]
  57. SaebS. ZhangM. KwasnyM. KarrC. KordingK. MohrD. The Relationship between clinical, momentary, and sensorbased assessment of depression.Int. Conf. Pervasive Comput. Technol. Healthc.2015201571010.4108/icst.pervasivehealth.2015.259034 26640739
     [Google Scholar]
  58. KuhnE. GreeneC. HoffmanJ. Preliminary evaluation of PTSD Coach, a smartphone app for post-traumatic stress symptoms.Mil. Med.20141791121810.7205/MILMED‑D‑13‑00271 24402979
     [Google Scholar]
  59. MinerA. KuhnE. HoffmanJ.E. OwenJ.E. RuzekJ.I. TaylorC.B. Feasibility, acceptability, and potential efficacy of the PTSD Coach app: A pilot randomized controlled trial with community trauma survivors.Psychol. Trauma20168338439210.1037/tra0000092 27046668
     [Google Scholar]
  60. PossematoK. KuhnE. JohnsonE. HoffmanJ.E. OwenJ.E. KanuriN. Using PTSD Coach in primary care with and without clinician support: A pilot randomized controlled trial.Gen. Hosp. Psychiatry201638949810.1016/j.genhosppsych.2015.09.005
     [Google Scholar]
  61. DennisT.A. O’TooleL.J. Mental health on the go effects of a gamified attention-bias modification mobile application in trait-anxious adults.Clin. Psychol. Sci.20142557659010.1177/2167702614522228 26029490
     [Google Scholar]
  62. MohrD.C. TomasinoK.N. LattieE.G. IntelliCare: An eclectic, skills-based app suite for the treatment of depression and anxiety.J. Med. Internet Res.2017191e1010.2196/jmir.6645 28057609
     [Google Scholar]
  63. BardramJ.E. FrostM. SzántóK. Faurholt-JepsenM. VinbergM. KessingL.V. Designing mobile health technology for bipolar disorder: a field trial of the monarca system. CHI '13: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems.27 April 2013New York, NY, United States, pp355010.1145/2470654.2481364
     [Google Scholar]
  64. Faurholt-JepsenM. FrostM. VinbergM. ChristensenE.M. BardramJ.E. KessingL.V. Smartphone data as objective measures of bipolar disorder symptoms.Psychiatry Res.20142171-212412710.1016/j.psychres.2014.03.009 24679993
     [Google Scholar]
  65. Faurholt-JepsenM. VinbergM. FrostM. ChristensenE.M. BardramJ.E. KessingL.V. Smartphone data as an electronic biomarker of illness activity in bipolar disorder.Bipolar Disord.201517771572810.1111/bdi.12332 26395972
     [Google Scholar]
  66. Faurholt-JepsenM. FrostM. RitzC. Daily electronic self-monitoring in bipolar disorder using smartphones – the MONARCA I trial: a randomized, placebo-controlled, single-blind, parallel group trial.Psychol. Med.201545132691270410.1017/S0033291715000410 26220802
     [Google Scholar]
  67. BushN.E. SkoppN. SmolenskiD. CrumptonR. FairallJ. Behavioral screening measures delivered with a smartphone app: psychometric properties and user preference.J. Nerv. Ment. Dis.20132011199199510.1097/NMD.0000000000000039 24177488
     [Google Scholar]
  68. Live Love Laugh Expands Rural Mental Health Program to ChhindwaraAvailable from: https://www.thelivelovelaughfoundation.org/ (accessed on 10-6-2024)
  69. Minds Foundation, Mental wellness for allAvailable from: https://www.mindsfoundation.org/ (accessed on 10-6-2024)
  70. National Institute of Mental Health, Transforming the Understanding and Treatment of Mental IllnessAvailable from: https://www.nimh.nih.gov/ (accessed on 10-6-2024)
  71. Schizophrenia Awareness AssociationAvailable from: https://schizophrenia.org.in/ (accessed on 10-6-2024)
  72. Creating Opportunities for People to Realize PotentialAvailable from: http://www.brac.net/ (accessed on 10-6-2024)
  73. Substance Abuse and Mental Health Services administrationAvailable from: https://www.samhsa.gov/resource/dbhis/nami-national-alliance-mental-illness (accessed on 10-6-2024)
  74. A Global Community of Mental Health Innovators.Available from: https://www.mhinnovation.net/organisations/banyan (accessed on 10-6-2024)
  75. A Community of People Who are Passionate about Shattering the Stigma around Mental Health.Available from: https://www.lonepack.org/ (accessed on 10-6-2024)
  76. Asha Deep FoundationAvailable from: https://www.adf.org.in/ (accessed on 10-6-2024)
  77. Mindroot Foundation, A Non-profit Organisation Dedicated to Mental HealthAvailable from: https://www.mindroot.org/ (accessed on 10-6-2024)
  78. GavinB. LyneJ. McNicholasF. The global impact on mental health almost 2 years into the COVID-19 pandemic.Ir. J. Psychol. Med.202138424324610.1017/ipm.2021.75 34879883
     [Google Scholar]
/content/journals/covid/10.2174/0126667975281808240702062456
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An Update on the Association of COVID-19 and Neuropsychiatric Disorders
Coronaviruses 6, E080724231724 (2025); https://doi.org/10.2174/0126667975281808240702062456
/content/journals/covid/10.2174/0126667975281808240702062456
/content/journals/covid/10.2174/0126667975281808240702062456
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  • Article Type:     Review Article
Keyword(s): bipolar disorder; COVID-19; neuropsychiatric disorders; nonpharmacological treatment; post-traumatic stress disorder; sleep disorder

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