Skip to content
2000
Volume 4, Issue 2
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Indoles are abundant in nature, and exhibit important biological properties such as anti-inflammatory, antihypertensive, dopaminergic, antineoplastic, anticonvulsant, analgesic, sedative, muscle relaxant, and antimicrobial activities. Synthesis, and functionalization of pharmacologically active indoles continue to receive considerable attention in the field of synthetic organic chemistry. Recent advances toward synthesis of natural, and unnatural indoles have been accelerated by transition metal catalysts, and in the context rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations with quite often-unique selectivity. This review describes the formation of indoles via rhodium catalyzed C-H, and X-H insertion (X = N, O, and S), cycloaddition, hydroformylation, bimetallic, and asymmetric hydrogenation reactions. Use of solid phase chemistry in rhodium catalyzed indole synthesis has also been discussed in the article.

Loading

Article metrics loading...

/content/journals/cos/10.2174/157017907780598862
2007-05-01
2025-10-13
Loading full text...

Full text loading...

/content/journals/cos/10.2174/157017907780598862
Loading

  • Article Type:
    Research Article
Keyword(s): Cycloaddition; Hydrogination; Indoles; Insertion; Rhodium(II)-catalyst; Solid-phase
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test