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image of Antiphytopathogenic Effects and the Preliminary Mechanisms of 5-nitro-8-hydroxyquinoline Derivatives

Abstract

Introduction

8-Hydroxyquinoline derivatives are compounds isolated from plants that possess a wide range of pharmacological activities. In our previous work, a series of novel 8-hydroxyquinoline derivatives was synthesized. Among them, the compound , 7-((4-(o-tolyl) piperazine-1-yl) methyl)-5-nitroquinolin-8-ol, demonstrated broad-spectrum antifungal activity against five plant pathogenic fungi with EC50 ranging from 4.69 to 12.61 μg/mL.

Methods

This investigation principally focused on determining the potential mechanisms of compound using ) as a model.

Results

The electron microscope observations revealed that after being treated with compound at 5 μg/mL, the mycelia became obviously curved, collapsed, and its integrity of the cell membrane was eventually destroyed.

Discussion

The compound influenced the production of reactive oxygen species, loss of mitochondrial membrane potential, and nuclear morphology. In addition, compound inhibited the enzyme activities related to mitochondrial function.

Conclusion

These findings will deepen our insights into the mechanisms of action of 8-hydroxyquinoline against and open new directions for the future development of effective antifungal agents to control phytopathogenic fungi.

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2025-10-17
2025-12-09

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/content/journals/cos/10.2174/0115701794397332250925103433
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Antiphytopathogenic Effects and the Preliminary Mechanisms of 5-nitro-8-hydroxyquinoline Derivatives
Bentham Science Publishers ; https://doi.org/10.2174/0115701794397332250925103433
/content/journals/cos/10.2174/0115701794397332250925103433
/content/journals/cos/10.2174/0115701794397332250925103433
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  • Article Type:     Research Article
Keywords: 8-hydroxyquinoline derivative ; fungicidal activity ; cell membrane integrity ; Botrytis cinerea ; mechanism of action ; mitochondrial function

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