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2000
Volume 22, Issue 4
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Palladium-catalyzed carbonylative cross-coupling reactions with various carbon monoxide (CO) sources cultivate competent routes for the synthesis of bulk and value-added chemicals. However, the practical use of this odorless, inflammable, lethal gas has always raised a concern for chemists. The attention and advancement of various CO-surrogates is surely welcomed as a green alternative to CO-gas. However, the main concern lies in the suitability and scalability of these CO-surrogate-driven reactions. Literature showed the progress of various ways to make CO from these CO surrogates. One of the most convenient sources is using metal carbonyls which are already known to lose CO easily. Among all the kinds, Mo(CO) gained much popularity but its toxic nature and demand for high temperatures restricted its use. However, Co(CO) is popular as a catalyst but as an CO-source reports are scarce. This low-melting CO-releaser was found effective in flourishing aminocarbonylation, alkoxycarbonylation, and reductive carbonylation under mild conditions. This mini-review portrays the recent developments of palladium-catalyzed carbonylation reactions using Co(CO) as a CO source.

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2025-09-01

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Co2(CO)8 as a CO-source for Pd-catalyzed Carbonylations: An Update
Curr. Org. Synth. 22, 421 (2025); https://doi.org/10.2174/0115701794302069240624045929
/content/journals/cos/10.2174/0115701794302069240624045929
/content/journals/cos/10.2174/0115701794302069240624045929
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  • Article Type:     Review Article
Keyword(s): alkoxycarbonylation; aminocarbonylation; Cobalt carbonyl; palladium-catalyzed carbonylation; reductive carbonylation; surrogates

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