oa Malic Acid as Bioorganocatalyst: Sustainable, One-pot and Multicomponent Synthesis of Benzopyrimido[4,5-b]quinoline in Biodegradable Glycerol

Background: Herein we disclosed a clean and sustainable, one pot, multicomponent protocol for the synthesis of Benzopyrimido[4,5-b]quinoline in glycerol in the presence of malic acid. Methods: The reported strategy eliminates the use of hazardous transition metal catalysts, acid, base and volatile organic solvents, which negatively affect the environment. In addition present methodology has advantages of mild reaction conditions, wide substrate scope, operational simplicity, easy workup, cost effectiveness and high yields of desired products. Conclusion: We have presented an efficient malic acid promoted, environmentally benign synthetic route to highly functionalized benzo[f]pyrimido[4,5-b]quinoline derivatives.