Chiral Bifunctional Ferrocenylphosphines as New Catalysts for aza- Morita-Baylis-Hillman Reactions of N-Sulfonated Imines with Methyl Vinyl Ketone

A series of new chiral bifunctional Ferrocenylphosphines was designed, synthesized and applied for the asymmetric aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK). The reaction proceeded under mild conditions to afford the desired aza-MBH adducts in moderate to high yields with up to 56% ee value.