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2000
Volume 12, Issue 4
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

Background

Oxidation with peroxides plays an important role in dopamine catabolism, the disruption of which is responsible for the development of neurodegenerative diseases, including Parkinson's disease. However, the mechanism of dopamine oxidation with peroxides has not been studied in detail, indicating the need to develop the kinetic patterns of the model reaction between dopamine hydrochloride and potassium peroxodisulfate.

Objective

This article aims to establish the kinetic patterns of dopamine hydrochloride oxidation in the presence of potassium peroxodisulfate using the conductometry method to monitor the reaction rate.

Methods

Conversion monitoring of dopamine hydrochloride and potassium peroxodisulfate was conducted by conductometry, which demonstrated high efficiency and was in good agreement with results independently obtained by potentiometry and UV spectroscopy.

Results

The use of conductometry to monitor the current concentration of dopamine during its oxidation in the presence of peroxodisulfate anion is described for the first time. It was found that the activation energy of dopamine hydrochloride oxidation by potassium peroxodisulfate is approximately 60 kJ mol-1, and the reaction proceeds through a highly ordered transition state with an activation entropy of –127 J mol-1 K-1, under the first-order kinetic law.

Conclusion

It is shown that dopamine acts as an activator of peroxide breakdown and can potentially serve as a source of radicals for the development of oxidative stress, which is one of the causes of neurodegenerative diseases, such as Parkinson's disease. To explain the first order of the reaction and the small value of the pre-exponential factor, an assumption was made about the intermediate formation of charge-transfer complexes between dopamine and the peroxodisulfate anion, as well as about the pronounced hydration of the transition state formed when these reagents approach each other.

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Kinetic Aspects and Mechanism of Peroxide Biomimetic Oxidation of Dopamine in Aqueous Solution
Curr. Organocatal. 12, 317 (2025); https://doi.org/10.2174/0122133372398080250811071652
/content/journals/cocat/10.2174/0122133372398080250811071652
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  • Article Type:     Research Article
Keyword(s): Dopamine; dopamine oxidation; kinetics; oxidative stress; Parkinson's disease; peroxodisulfate; phenol oxidation

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