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image of Unlocking the Catalytic Potential of Encapsulated Metal Oxide Nanocomposites for Domino Heterocyclization of Medicinal Privileged Scaffolds

Abstract

Introduction

Encapsulated metal oxide nanocomposites actively engaged in heterocyclic transformations represent a potent and adaptable notion in catalysis. The facile derivatization of metal oxide nanocomposites by surface modification has popularized them as versatile catalysts for domino heterocyclization.

Methods

With the emergence of multicomponent domino reactions (MDRs) as frontier synthetic tools for medicinally relevant heterocycles, optimally satisfying one-step syntheses is the domain of current research.

Results

The search for a suitable catalyst for the domino multiple bond-forming synthesis of medicinal heterocyclic scaffolds has become a central evolving theme. In particular, metal oxide nanocomposites have drawn considerable attention as viable catalytic alternatives to conventional materials because of their facile adaptability in stabilizing functional cores or activating surfaces.

Discussion

This review discusses the catalytic potential of derivatized metal oxide nanocomposites immobilized into or supported on various materials (metals, inorganic and organic nanocomposites, .) for domino heterocyclization.

Conclusion

This review highlights how the encapsulation of moieties on the surface of metal oxide nanoparticles has improved their catalytic recovery and reusability, as well as product yield, especially in domino synthesis. Furthermore, this review summarizes the domino synthesis of heterocycles with privileged medicinal scaffolds. The present review provides new insights into designing domino protocols that utilize metal oxide nanocomposites as vital catalysts for drug discovery at the industrial level.

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2025-09-03
2025-09-27

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Unlocking the Catalytic Potential of Encapsulated Metal Oxide Nanocomposites for Domino Heterocyclization of Medicinal Privileged Scaffolds
Bentham Science Publishers ; https://doi.org/10.2174/0122133372393349250826060305
/content/journals/cocat/10.2174/0122133372393349250826060305
/content/journals/cocat/10.2174/0122133372393349250826060305
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  • Article Type:     Research Article
Keywords: domino synthesis ; Nanocomposites ; medicinal privileged scaffolds ; medicinal scaffolds ; metal oxide NPs ; domino heterocyclization

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