Skip to content
2000
image of Mechanisms and Mitochondria-targeted Therapies for Retinal Ganglion Cell Degeneration in Glaucoma

There is no abstract available.

Loading

Article metrics loading...

/content/journals/cnsnddt/10.2174/0118715273397014250604050651
2025-06-10
2025-09-30
Loading full text...

Full text loading...

/deliver/fulltext/cnsnddt/10.2174/0118715273397014250604050651/BMS-CNSNDDT-2025-80.html?itemId=/content/journals/cnsnddt/10.2174/0118715273397014250604050651&mimeType=html&fmt=ahah

References

  1. Jindahra P. Hengsiri N. Witoonpanich P. Poonyathalang A. Pulkes T. Tunlayadechanont S. Thadanipon K. Vanikieti K. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in alzheimer’s disease using optical coherence tomography. Clin. Ophthalmol. 2020 14 2995 3000 10.2147/OPTH.S276625 33061285
    [Google Scholar]
  2. Sen S. Saxena R. Tripathi M. Vibha D. Dhiman R. Neurodegeneration in Alzheimer’s disease and glaucoma: Overlaps and missing links. Eye (Lond.) 2020 34 9 1546 1553 10.1038/s41433‑020‑0836‑x 32152519
    [Google Scholar]
  3. Wilkison S.J. Bright C.L. Vancini R. Song D.J. Bomze H.M. Cartoni R. Local accumulation of axonal mitochondria in the optic nerve glial lamina precedes myelination. Front. Neuroanat. 2021 15 678501 10.3389/fnana.2021.678501 34093141
    [Google Scholar]
  4. Ulhaq Z.S. Bittencourt G.B. Soraya G.V. Istifiani L.A. Pamungkas S.A. Ogino Y. Nurputra D.K. Tse W.K.F. Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation. Mol. Aspects Med. 2024 96 101238 10.1016/j.mam.2023.101238 38215610
    [Google Scholar]
  5. Yang T.H. Kang E.Y.C. Lin P.H. Yu B.B.C. Wang J.H.H. Chen V. Wang N.K. Mitochondria in retinal ganglion cells: Unraveling the metabolic nexus and oxidative stress. Int. J. Mol. Sci. 2024 25 16 8626 10.3390/ijms25168626 39201313
    [Google Scholar]
  6. Ju W.K. Perkins G.A. Kim K.Y. Bastola T. Choi W.Y. Choi S.H. Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells. Prog. Retin. Eye Res. 2023 95 101136 10.1016/j.preteyeres.2022.101136 36400670
    [Google Scholar]
  7. Williams P.A. Harder J.M. Foxworth N.E. Cochran K.E. Philip V.M. Porciatti V. Smithies O. John S.W.M. Vitamin B. Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 2017 355 6326 756 760 10.1126/science.aal0092 28209901
    [Google Scholar]
  8. Yaribeygi H. Panahi Y. Javadi B. Sahebkar A. The underlying role of oxidative stress in neurodegeneration: A mechanistic review. CNS Neurol. Disord. Drug Targets 2018 17 3 207 215 10.2174/1871527317666180425122557 29692267
    [Google Scholar]
  9. Zhong C. Yang J. Zhang Y. Fan X. Fan Y. Hua N. Li D. Jin S. Li Y. Chen P. Chen Y. Cai X. Zhang Y. Jiang L. Yang W. Yu P. Lin H. TRPM2 mediates hepatic ischemia-reperfusion injury via Ca(2+)-induced mitochondrial lipid peroxidation through increasing ALOX12 expression. Research 2023 6 0159 10.34133/research.0159
    [Google Scholar]
  10. Li Y. Liu X. Lin R. Peng X. Wang X. Meng F. Jin S. Lv W. Liu X. Du Z. Wen S. Bai R. Ruan Y. Zhou H. Zou R. Tang R. Liu N. Ibrutinib promotes atrial fibrillation by disrupting a-kinase anchoring protein 1-mediated mitochondrial quality surveillance in cardiomyocyte. Research 2024 7 0509 10.34133/research.0509.
    [Google Scholar]
  11. Edwards G. Perkins G.A. Kim K.Y. Kong Y. Lee Y. Choi S.H. Liu Y. Skowronska-Krawczyk D. Weinreb R.N. Zangwill L. Strack S. Ju W.K. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020 11 4 254 10.1038/s41419‑020‑2456‑6 32312949
    [Google Scholar]
  12. Hu X. Dai Y. Zhang R. Shang K. Sun X. Overexpression of optic atrophy type 1 protects retinal ganglion cells and upregulates parkin expression in experimental glaucoma. Front. Mol. Neurosci. 2018 11 350 10.3389/fnmol.2018.00350 30323741
    [Google Scholar]
  13. Hass D.T. Barnstable C.J. Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma. J. Neurosci. 2019 39 18 3582 3596 30814312
    [Google Scholar]
  14. Dai Y. Hu X. Sun X. Overexpression of parkin protects retinal ganglion cells in experimental glaucoma. Cell Death Dis. 2018 9 2 88 10.1038/s41419‑017‑0146‑9 29367744
    [Google Scholar]
  15. Yao F. Peng J. Zhang E. Ji D. Gao Z. Tang Y. Yao X. Xia X. Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma. Cell Death Differ. 2023 30 1 69 81 10.1038/s41418‑022‑01046‑4 35933500
    [Google Scholar]
  16. Zhao W. Fan C. Hu X. Ban X. Wan H. He Y. Zhang Q. Xiong K. Regulated cell death of retinal ganglion cells in glaucoma: Molecular insights and therapeutic potentials. Cell. Mol. Neurobiol. 2023 43 7 3161 3178 10.1007/s10571‑023‑01373‑1 37338781
    [Google Scholar]
  17. Basavarajappa D. Galindo-Romero C. Gupta V. Agudo-Barriuso M. Gupta V.B. Graham S.L. Chitranshi N. Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology. Mol. Aspects Med. 2023 94 101216 10.1016/j.mam.2023.101216 37856930
    [Google Scholar]
  18. Zeng Z. You M. Fan C. Rong R. Li H. Xia X. Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma. Redox Biol. 2023 62 102687 10.1016/j.redox.2023.102687 36989574
    [Google Scholar]
  19. Wan H. Ban X. He Y. Yang Y. Hu X. Shang L. Wan X. Zhang Q. Xiong K. Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia–reperfusion injury. Neural Regen. Res. 2025 10.4103/NRR.NRR‑D‑24‑00674 39819824
    [Google Scholar]
  20. Harun-Or-Rashid M. Pappenhagen N. Zubricky R. Coughlin L. Jassim A.H. Inman D.M. MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma. Neurobiol. Dis. 2020 141 104944 10.1016/j.nbd.2020.104944 32422282
    [Google Scholar]
  21. Williams P.A. Casson R.J. Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma. Neural Regen. Res. 2024 19 8 1637 1638 10.4103/1673‑5374.389638 38103218
    [Google Scholar]
  22. Thaler S. Choragiewicz T.J. Rejdak R. Fiedorowicz M. Turski W.A. Tulidowicz-Bielak M. Zrenner E. Schuettauf F. Zarnowski T. Neuroprotection by acetoacetate and β-hydroxybutyrate against NMDA-induced RGC damage in rat—possible involvement of kynurenic acid. Graefes Arch. Clin. Exp. Ophthalmol. 2010 248 12 1729 1735 10.1007/s00417‑010‑1425‑7 20532550
    [Google Scholar]
  23. Tribble J.R. Otmani A. Sun S. Ellis S.A. Cimaglia G. Vohra R. Jöe M. Lardner E. Venkataraman A.P. Domínguez-Vicent A. Kokkali E. Rho S. Jóhannesson G. Burgess R.W. Fuerst P.G. Brautaset R. Kolko M. Morgan J.E. Crowston J.G. Votruba M. Williams P.A. Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction. Redox Biol. 2021 43 101988 10.1016/j.redox.2021.101988 33932867
    [Google Scholar]
  24. Tang D. Liu X. Chen J. Mitoquinone intravitreal injection ameliorates retinal ischemia-reperfusion injury in rats involving SIRT1/Notch1/NADPH axis. Drug Dev. Res. 2022 83 3 800 810 35014081
    [Google Scholar]
  25. Zinovkin R.A. Zamyatnin A.A. Mitochondria-targeted drugs. Curr. Mol. Pharmacol. 2019 12 3 202 214 10.2174/1874467212666181127151059 30479224
    [Google Scholar]
  26. Liu H. Hu F.Y. Xu P. Wu J.H. Regulation of mitophagy by metformin improves the structure and function of retinal ganglion cells following excitotoxicity-induced retinal injury. Exp. Eye Res. 2022 217 108979 10.1016/j.exer.2022.108979 35143835
    [Google Scholar]
  27. Chi J. Fan B. Li Y. Jiao Q. Li G.Y. Mitochondrial transplantation: A promising strategy for the treatment of retinal degenerative diseases. Neural Regen. Res. 2024 39851134
    [Google Scholar]
/content/journals/cnsnddt/10.2174/0118715273397014250604050651
Loading
/content/journals/cnsnddt/10.2174/0118715273397014250604050651
Loading

Data & Media loading...


  • Article Type:
    Editorial
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test