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image of Harnessing Nanoparticles for Effective Drug Delivery: A Comprehensive Review of Techniques and Therapeutic Applications

Abstract

The current scenario of research is moving from the nanosized scale. This research posits that nanoparticle-based drug delivery systems can significantly enhance the therapeutic efficacy and bioavailability of poorly water-soluble drugs, thereby addressing critical challenges in the treatment of various diseases, including cancer, diabetes, and dermatological conditions.

In this study, a comprehensive review of various nanoformulation techniques was conducted, including nanoemulsions, lipid-based formulations, and polymeric nanoparticles. The study involved analyzing existing literature on the preparation methods, characterization, and optimization of nanoparticles for drug delivery. Additionally, case studies of approved and clinical trial drugs utilizing nanoparticle carriers were examined to assess their impact on bioavailability and therapeutic outcomes.

The findings indicate that nanoparticle formulations not only improve the solubility and stability of hydrophobic drugs but also facilitate targeted delivery, resulting in enhanced therapeutic effects and reduced side effects. Specific examples highlighted include the successful application of nanoparticles in gene therapy and oncology, demonstrating their potential to revolutionize treatment paradigms. By reviewing this article, the reviewer gets knowledge about the different array of tools, methods, and development achieved in the field of nanotechnology, and the article represents the sufficient information needed to achieve the best design of nanoformulation for drug development and bridge the gaps faced by researchers and the scientific community.

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2025-04-08
2025-09-28

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Harnessing Nanoparticles for Effective Drug Delivery: A Comprehensive Review of Techniques and Therapeutic Applications
Bentham Science Publishers ; https://doi.org/10.2174/0124054615351522250307173107
/content/journals/cnm/10.2174/0124054615351522250307173107
/content/journals/cnm/10.2174/0124054615351522250307173107
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  • Article Type:     Review Article
Keywords: diabetes ; cancer ; gene delivery ; dermal applications ; Nanoparticulate ; treatment

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