Enzymatic Activity of Glucose Oxidase on Mesoporous TiO2:Mn Surfaces

Introduction: It is well known, that titanium dioxide (TiO2) nanoparticles can lead to the generation of reactive oxygen species (ROS) upon photoexcitation. Methods: In this work, we investigated mesoporous surfaces based on TiO2 nanoparticles doped with 0.6-0.7% manganese (Mn), which showed reduced photoactivity and were based on the more stable rutile polymorph of titania.Results: In particular, we showed spectrophotometrically that the enzyme glucose oxidase (GOD) can be successfully adsorbed up to 80% while retaining its bioactivity in contact with the TiO2:Mn-based surface.Conclusion: We propose that this study could potentially give rise to biocompatible surfaces for biosensing applications.