Dermal Nano-Phytomedicines: A Tool Alluring Towards Plausible Treatment of Photoaging

Ultraviolet (UV) radiation serves as a principal carter to dermatoheliosis, also professed as extrinsic aging or photoaging that encompasses premature skin vicissitudes secondary to damage instigated by chronic sun exposure. The present literature study embarks on the fundamental understanding of molecular/pathophysiological mechanisms and signals transduction pathways convoluted in the process of photoaging. Special impetus has also been laid on the morphological, biological and histological aspects highlighting the impact of age, gender, type of skin, intensity of radiation exposure and cellular biomarkers. Further, this review examines the state-of-the-art practices or experimental models (such as in vitro cell lines/in vivo animal models/ex vivo skin models) employed for the physicochemical and toxicological characterization of nanobiomaterials in photoaging research. Efforts have been made to recapitulate the potential application of phytoprotectants-based monotherapies or approaches in the efficacious management of photoaging. Furthermore, the study aims to disseminate the recent advances (in terms of patented compositions, novel nanotechnologies and commercial nanoformulations (having diverse anti-aging and photo-protective product portfolio) available in the clinical settings or in the cosmaceutical sector for improvising the aesthetic performance) underlining the tremendous growth in the nutracosmaceutical sector. The authors firmly believe that the current review shall not only capture the interest of readers towards the process of dermatoheliosis but could also rekindle the attention of the scientific community for inclusive assimilation of nanotechnology with nutraceuticals that may aid as a barrier against exogenous or endogenous toxic substances currently in practice to treat a variety of skin disorders.