s Gold Nanoparticles-based Bio-Sensing Methods for Tumor-related Biomedical Applications in Bodily Fluids

Background: Cancer is one of most dangerous diseases that seriously threaten human health, while tumor biomarkers provide important information for clinical diagnosis and treatment of cancers. Given the low abundance of tumor biomarkers in the bodily fluids at the early stage of cancers, it is particularly important to develop bio sensing methods for accurate measurement of tumor biomarkers with high sensitivity. Objective: Nowadays, gold nanoparticles (AuNPs) that have remarkable physical and chemical properties are extensively used in the design of biosensing strategies. In this context, we mainly review the research progress of AuNPs-based biosensing methods for tumor-related biomedical applications in bodily fluids in recent years. Results: Optical, electrochemical and mass spectrometric biosensing methods using AuNPs are widely used for excellent performances in the assay of tumor biomarkers. Conclusion: The existing methods demonstrate high clinical value, while challenges and expectation of biosensing method in tumor-related biomedical application are also discussed.