Highly Resolution of Propranolol Using Oxidized Multi-walled Carbon Nanotubes and β-cyclodextrin Derivatives as Impregnating Reagents

By using oxidized multi-walled carbon nanotubes and β-cyclodextrin derivatives (methyl-β-cyclodextrin or hydroxypropyl-β- cyclodextrin) as impregnating reagents, high efficiently resolution of (±)-propranolol, a kind of commonly used β-blockers, has been achieved on abovementioned reagents impregnated silica gel GF254 layers. The solvent system tert-butanol-acetonitrile with various volume ratios was further investigated. By detecting the spots at 254 nm with a UV lamp, the obtained chiral separation factors indicated oxidized multi-walled carbon nanotubes and β-cyclodextrin derivatives impregnated TLC plates could be used for effectively chiral recognition of racemic compounds.