Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Aim of this paper is to study the load-drug mechanism of polybutylcyanocrylate nanoparticles and the physical stability of albendazole- polybutylcyanocrylate nanoparticle (ABZ-PBCA-NP). The adsorption mechanism between albendazole with polybutylcyanocrylate nanoparticle in different phosphate buffer solution (PBS) were investigated with isothermadsorption method. The constants of stability constants of albendazole-loading nanoparticles were predicted by determined the conductance rate of nanoparticles colloid under predetermined temperature in interval time. At the same time, several stabilizer including polyvinyl pyrrolidone (PVP), carboxymethylcellulose sodium (CMC-Na) and hydroxoy-propyl methyl cellulose (HPMC) was screen for improving stability and fluidity of nanoparticle suspension. The results showed that the mechanism of drug-load in nanoparticle was fitted the Langmuir equation. The conductance rate indicated that load-drug nanoparticle in suspension was unstability due to nature aggregation tendency and improved by reinforced with 4% PVP in solution.